Molecular and anatomical determinants of central leptin resistance (Q36108714)

12 August 2017

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title

Molecular and anatomical determinants of central leptin resistance (English)

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12 August 2017

Heike Münzberg

1

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PubMed ID

15856064

12 August 2017

Martin G Myers

series ordinal

2

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PubMed ID

15856064

12 August 2017

language of work or name

English

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publication date

1 May 2005

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12 August 2017

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12 August 2017

8

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12 August 2017

5

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12 August 2017

566-570

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https://scigraph.springernature.com/pub.10.1038/nn1454

12 August 2017

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cites work

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Acute intravenous leptin infusion increases glucose turnover but not skeletal muscle glucose uptake in ob/ob mice

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Intracerebroventricular leptin regulates hepatic but not peripheral glucose fluxes.

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Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice

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Regulation of Jak kinases by intracellular leptin receptor sequences.

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Central nervous system control of food intake

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Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area.

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Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

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Arcuate Nucleus-Specific Leptin Receptor Gene Therapy Attenuates the Obesity Phenotype of Koletsky (fak/fak) Rats

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The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity

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Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis

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Jaks and Stats in signaling by the cytokine receptor superfamily

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Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization

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Activation of downstream signals by the long form of the leptin receptor

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Divergent roles of SHP-2 in ERK activation by leptin receptors

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SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985

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Role of Signal Transducer and Activator of Transcription 3 in Regulation of Hypothalamic Proopiomelanocortin Gene Expression by Leptin

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STAT3 signalling is required for leptin regulation of energy balance but not reproduction

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CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2

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Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop

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Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein

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Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity

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Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling

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Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta

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1 reference

Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia

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Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1

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Intracellular signalling. Key enzyme in leptin-induced anorexia

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Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism

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Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

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LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin

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Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis

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Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.

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Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action

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Diet-induced obese mice develop peripheral, but not central, resistance to leptin

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Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

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The many lives of leptin

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Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset

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The functional and structural border of the neurohemal region of the median eminence

21 January 2018

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A second look at the barriers of the medial basal hypothalamus

21 January 2018

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Region-specific leptin resistance within the hypothalamus of diet-induced obese mice.

21 January 2018

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PTP1B regulates leptin signal transduction in vivo

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Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B.

21 January 2018

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Identification of SOCS-3 as a potential mediator of central leptin resistance

21 January 2018

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Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3.

21 January 2018

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Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

21 January 2018

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Photoperiodic regulation of leptin sensitivity in the Siberian hamster, Phodopus sungorus, is reflected in arcuate nucleus SOCS-3 (suppressor of cytokine signaling) gene expression.

21 January 2018

1 reference

SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice

21 January 2018

1 reference

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

21 January 2018

1 reference

Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms

21 January 2018

1 reference

Hypothalamic sensing of fatty acids

21 January 2018

1 reference

Exogenous glutamate enhances glutamate receptor subunit expression during selective neuronal injury in the ventral arcuate nucleus of postnatal mice

21 January 2018

1 reference

Acute stimulation of glucose metabolism in mice by leptin treatment

21 January 2018

1 reference

IRS-2 pathways integrate female reproduction and energy homeostasis

21 January 2018

1 reference

Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3.

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NN1454

1 reference

12 August 2017

1 reference

PubMed ID

15856064