Aggregatibacter actinomycetemcomitans cytolethal distending toxin activates the NLRP3 inflammasome in human macrophages, leading to the release of proinflammatory cytokines (Q35187647)

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English	Aggregatibacter actinomycetemcomitans cytolethal distending toxin activates the NLRP3 inflammasome in human macrophages, leading to the release of proinflammatory cytokines	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

7 August 2017

Aggregatibacter actinomycetemcomitans cytolethal distending toxin activates the NLRP3 inflammasome in human macrophages, leading to the release of proinflammatory cytokines (English)

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Europe PubMed Central

PubMed publication ID

7 August 2017

inflammasome complex

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based on heuristic

inferred from title

Aggregatibacter actinomycetemcomitans

object named as

Aggregatibacter actinomycetemcomitans

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based on heuristic

inferred from title

2

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1 June 2020

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Bruce J Shenker

1

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1 June 2020

Lisa P Walker

3

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1 June 2020

Ali Zekavat

4

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1 June 2020

Monika Damek Scuron

5

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1 June 2020

Kathleen Boesze-Battaglia

6

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1 June 2020

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2 February 2015

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7 August 2017

Infection and Immunity

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1 June 2020

83

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1 June 2020

4

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1 June 2020

1487-1496

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1 June 2020

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1 reference

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13 July 2018

Blockade of the PI-3K signalling pathway by the Aggregatibacter actinomycetemcomitans cytolethal distending toxin induces macrophages to synthesize and secrete pro-inflammatory cytokines

1 reference

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The keystone-pathogen hypothesis.

1 reference

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P2X7 receptor regulation of non-classical secretion from immune effector cells

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The anti-tumorigenic mushroom Agaricus blazei Murill enhances IL-1β production and activates the NLRP3 inflammasome in human macrophages

1 reference

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13 July 2018

Control of innate and adaptive immunity by the inflammasome

1 reference

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13 July 2018

Activation of an NLRP3 inflammasome restricts Mycobacterium kansasii infection

1 reference

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13 July 2018

Sensing and reacting to microbes through the inflammasomes

1 reference

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A.actinomycetemcomitans-induced periodontal disease promotes systemic and local responses in rat periodontium

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Impaired phagocytosis in localized aggressive periodontitis: rescue by Resolvin E1

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Cross-regulation between the IL-1β/IL-18 processing inflammasome and other inflammatory cytokines

1 reference

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Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing

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TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk.

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Chlamydial infection of monocytes stimulates IL-1beta secretion through activation of the NLRP3 inflammasome

1 reference

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Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase.

1 reference

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ATP-dependent activation of an inflammasome in primary gingival epithelial cells infected by Porphyromonas gingivalis

1 reference

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13 July 2018

Sensing pathogens and danger signals by the inflammasome

1 reference

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13 July 2018

Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages

1 reference

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13 July 2018

IFN-beta production by TLR4-stimulated innate immune cells is negatively regulated by GSK3-beta

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13 July 2018

Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells

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13 July 2018

Role of phosphoinositide 3-kinase in innate immunity

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13 July 2018

A novel mode of action for a microbial-derived immunotoxin: the cytolethal distending toxin subunit B exhibits phosphatidylinositol 3,4,5-triphosphate phosphatase activity.

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Opposite regulation of IL-1beta and secreted IL-1 receptor antagonist production by phosphatidylinositide-3 kinases in human monocytes activated by lipopolysaccharides or contact with T cells

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Cholesterol-rich membrane microdomains mediate cell cycle arrest induced by Actinobacillus actinomycetemcomitans cytolethal-distending toxin

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Cytolethal distending toxins

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Assembly and function of a bacterial genotoxin

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Cytolethal distending toxin (CDT): a bacterial weapon to control host cell proliferation?

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Induction of apoptosis in human T cells by Actinobacillus actinomycetemcomitans cytolethal distending toxin is a consequence of G2 arrest of the cell cycle

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CdtA, CdtB, and CdtC form a tripartite complex that is required for cytolethal distending toxin activity

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Escherichia coli CdtB mediates cytolethal distending toxin cell cycle arrest

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The cytolethal distending toxin family

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12 December 2020

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