TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk. (Q34786821)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20940366%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

title

TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20940366%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

0 references

George Hajishengallis

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20940366%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

author name string

J Brown

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20940366%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

H Wang

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20940366%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

M Martin

4

1 reference

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15 February 2020

language of work or name

English

0 references

publication date

12 October 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20940366%20AND%20SRC:MED&resulttype=core&format=json

Journal of Dental Research

15 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20940366%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

volume

90

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20940366%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

page(s)

417-427

1 reference

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15 February 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20940366%20AND%20SRC:MED&resulttype=core&format=json

mTOR and GSK-3 shape the CD4+ T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS.

15 February 2020

cites work

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Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

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Endotoxin tolerance: new mechanisms, molecules and clinical significance

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The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs

8 July 2018

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Mal connects TLR2 to PI3Kinase activation and phagocyte polarization

8 July 2018

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Induction of distinct TLR2-mediated proinflammatory and proadhesive signaling pathways in response to Porphyromonas gingivalis fimbriae

8 July 2018

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Pathogen induction of CXCR4/TLR2 cross-talk impairs host defense function

8 July 2018

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Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells

8 July 2018

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Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34.

8 July 2018

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Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance

8 July 2018

1 reference

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Intracellular NOD-like receptors in host defense and disease

8 July 2018

1 reference

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Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance

8 July 2018

1 reference

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Myeloid differentiation factor 88-independent Toll-like receptor pathway: Sustaining inflammation or promoting tolerance?

8 July 2018

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S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt.

8 July 2018

1 reference

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Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis

8 July 2018

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Porphyromonas gingivalis fimbriae proactively modulate beta2 integrin adhesive activity and promote binding to and internalization by macrophages

8 July 2018

1 reference

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Differential interactions of fimbriae and lipopolysaccharide from Porphyromonas gingivalis with the Toll-like receptor 2-centred pattern recognition apparatus

8 July 2018

1 reference

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Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

8 July 2018

1 reference

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Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4.

8 July 2018

1 reference

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Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells

8 July 2018

1 reference

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Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

8 July 2018

1 reference

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IkappaBNS inhibits induction of a subset of Toll-like receptor-dependent genes and limits inflammation.

8 July 2018

1 reference

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Cryopyrin activates the inflammasome in response to toxins and ATP

8 July 2018

1 reference

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Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling

8 July 2018

1 reference

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Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

8 July 2018

1 reference

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Negative regulation of Toll-like-receptor signaling by IRF-4.

8 July 2018

1 reference

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Ubiquitin signalling in the NF-kappaB pathway

8 July 2018

1 reference

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Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3.

8 July 2018

1 reference

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Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88

8 July 2018

1 reference

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Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling

8 July 2018

1 reference

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Transcriptional suppression of interleukin-12 gene expression following phagocytosis of apoptotic cells

8 July 2018

1 reference

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Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling

8 July 2018

1 reference

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Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

8 July 2018

1 reference

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NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

8 July 2018

1 reference

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TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway

8 July 2018

1 reference

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Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

8 July 2018

1 reference

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An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

8 July 2018

1 reference

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Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan

8 July 2018

1 reference

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NALPs: a novel protein family involved in inflammation

8 July 2018

1 reference

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Opsonization of apoptotic cells by autologous iC3b facilitates clearance by immature dendritic cells, down-regulates DR and CD86, and up-regulates CC chemokine receptor 7.

8 July 2018

1 reference

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The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

8 July 2018

1 reference

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Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells

8 July 2018

1 reference

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IRF3 mediates a TLR3/TLR4-specific antiviral gene program

8 July 2018

1 reference

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Toll receptors, CD14, and macrophage activation and deactivation by LPS.

8 July 2018

1 reference

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Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins

8 July 2018

1 reference

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Phagosome maturation: aging gracefully

8 July 2018

1 reference

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The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells

8 July 2018

1 reference

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The phosphoinositide 3-kinase pathway

8 July 2018

1 reference

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IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase

8 July 2018

1 reference

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The p50-homodimer mechanism in tolerance to LPS.

8 July 2018

1 reference

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Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

8 July 2018

1 reference

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TIRAP: an adapter molecule in the Toll signaling pathway

8 July 2018

1 reference

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

8 July 2018

1 reference

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Discrimination of bacterial lipoproteins by Toll-like receptor 6

8 July 2018

1 reference

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A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation

8 July 2018

1 reference

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Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway

8 July 2018

1 reference

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Proinflammatory cytokines

8 July 2018

1 reference

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Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: dysregulation of cytokine, chemokine, and toll-like receptor 2 and 4 gene expression

8 July 2018

1 reference

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Characterization of interleukin-1 receptor-associated kinase in normal and endotoxin-tolerant cells

8 July 2018

1 reference

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TLR6: A novel member of an expanding toll-like receptor family

8 July 2018

1 reference

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Complement-dependent clearance of apoptotic cells by human macrophages

8 July 2018

1 reference

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Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

8 July 2018

1 reference

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MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

8 July 2018

1 reference

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NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

8 July 2018

1 reference

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IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

8 July 2018

1 reference

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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

8 July 2018

1 reference

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TRAF6 is a signal transducer for interleukin-1

8 July 2018

1 reference

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Receptors for C3b and C3bi promote phagocytosis but not the release of toxic oxygen from human phagocytes

8 July 2018

1 reference

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Activation of complement components C3 and C5 by a cysteine proteinase (gingipain-1) from Porphyromonas (Bacteroides) gingivalis.

8 July 2018

1 reference

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Microbial hijacking of complement-toll-like receptor crosstalk

8 July 2018

1 reference

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Potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharide-tolerant human monocytes: demonstration in isolated monocytes from cystic fibrosis patients.

26 October 2018

1 reference

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The TSC-mTOR signaling pathway regulates the innate inflammatory response

26 October 2018

1 reference

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Complement receptor 3 blockade promotes IL-12-mediated clearance of Porphyromonas gingivalis and negates its virulence in vivo

26 October 2018

1 reference

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Fimbrial proteins of porphyromonas gingivalis mediate in vivo virulence and exploit TLR2 and complement receptor 3 to persist in macrophages.

26 October 2018

1 reference

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IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075579

Rewiring phagocytic signal transduction.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075579

SHIP represses the generation of alternatively activated macrophages

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075579

Integrin activation by bacterial fimbriae through a pathway involving CD14, Toll-like receptor 2, and phosphatidylinositol-3-kinase

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075579

PI3K-Akt pathway suppresses coagulation and inflammation in endotoxemic mice.

26 October 2018

1 reference

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Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide

26 October 2018

1 reference

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Multiple mechanisms of reduced major histocompatibility complex class II expression in endotoxin tolerance.

26 October 2018

1 reference

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Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075579

Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice

26 October 2018

1 reference

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NF-kappaB expression in mononuclear cells of patients with sepsis resembles that observed in lipopolysaccharide tolerance

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075579

Toll-like receptors and innate immunity

26 October 2018

1 reference

12 December 2020

PI3K-mediated negative feedback regulation of IL-12 production in DCs

1 reference

12 December 2020

SOCS-1 participates in negative regulation of LPS responses

1 reference

12 December 2020

LPS-Induced Upregulation of SHIP Is Essential for Endotoxin Tolerance

1 reference

12 December 2020

The anti-inflammatory response dominates after septic shock: association of low monocyte HLA-DR expression and high interleukin-10 concentration

1 reference

12 December 2020

Unresponsiveness of MyD88-deficient mice to endotoxin

1 reference

12 December 2020

1 reference

12 December 2020

Biphasic effect of gingipains from Porphyromonas gingivalis on the human complement system

1 reference

12 December 2020

Impaired antigen presentation by human monocytes during endotoxin tolerance

1 reference

12 December 2020

Endotoxin-induced maturation of MyD88-deficient dendritic cells

1 reference

12 December 2020

Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells

1 reference

12 December 2020

Identifiers

DOI

10.1177/0022034510381264

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20940366%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20940366%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference