Engineering an antibiotic to fight cancer: optimization of the novobiocin scaffold to produce anti-proliferative agents (Q35188962)

7 August 2017

title

Engineering an antibiotic to fight cancer: optimization of the novobiocin scaffold to produce anti-proliferative agents (English)

1 reference

7 August 2017

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10

Brian S J Blagg

1 reference

7 August 2017

Huiping Zhao

1

1 reference

7 August 2017

Alison C Donnelly

2

1 reference

7 August 2017

Bhaskar R Kusuma

3

1 reference

7 August 2017

Gary E L Brandt

4

1 reference

7 August 2017

Douglas Brown

5

1 reference

7 August 2017

Roger A Rajewski

6

1 reference

7 August 2017

George Vielhauer

7

1 reference

7 August 2017

Jeffrey Holzbeierlein

8

1 reference

7 August 2017

Mark S Cohen

9

1 reference

7 August 2017

language of work or name

English

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publication date

9 May 2011

1 reference

Journal of Medicinal Chemistry

7 August 2017

published in

1 reference

7 August 2017

volume

54

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7 August 2017

issue

11

1 reference

7 August 2017

page(s)

3839-3853

1 reference

To fold or not to fold: modulation and consequences of Hsp90 inhibition

7 August 2017

cites work

1 reference

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28 July 2018

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KU135, a novel novobiocin-derived C-terminal inhibitor of the 90-kDa heat shock protein, exerts potent antiproliferative effects in human leukemic cells

28 July 2018

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Natural product inhibitors of Hsp90: potential leads for drug discovery

28 July 2018

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Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket

28 July 2018

1 reference

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The design, synthesis, and evaluation of coumarin ring derivatives of the novobiocin scaffold that exhibit antiproliferative activity

28 July 2018

1 reference

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Development of novobiocin analogues that manifest anti-proliferative activity against several cancer cell lines

28 July 2018

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Hsp90: a novel target for the disruption of multiple signaling cascades

28 July 2018

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New novobiocin analogues as antiproliferative agents in breast cancer cells and potential inhibitors of heat shock protein 90.

28 July 2018

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Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors

28 July 2018

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28 July 2018

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Effectiveness of hsp90 inhibitors as anti-cancer drugs

28 July 2018

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28 July 2018

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28 July 2018

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Hsp90 inhibitors identified from a library of novobiocin analogues

28 July 2018

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28 July 2018

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28 July 2018

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Carbohydrates as the next frontier in pharmaceutical research

28 July 2018

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Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone

28 July 2018

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Heat shock protein 90 as a molecular target for cancer therapeutics

28 July 2018

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Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

28 July 2018

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Heat-shock protein 90, a chaperone for folding and regulation

28 July 2018

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28 July 2018

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HSP90 as a new therapeutic target for cancer therapy: the story unfolds

28 July 2018

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Structure-activity relationship in two series of aminoalkyl substituted coumarin inhibitors of gyrase B.

28 July 2018

1 reference

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Hsp90 & Co. - a holding for folding

28 July 2018

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The entropic penalty of ordered water accounts for weaker binding of the antibiotic novobiocin to a resistant mutant of DNA gyrase: a thermodynamic and crystallographic study

28 July 2018

1 reference

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The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin

28 July 2018

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Molecular mechanisms of drug inhibition of DNA gyrase

28 July 2018

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The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography

28 July 2018

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Heat-induced chaperone activity of HSP90.

28 July 2018

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28 July 2018

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Synthesis and Evaluation of Noviose Replacements on Novobiocin that Manifest Anti-proliferative Activity

28 July 2018

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Synthesis and biological activity of simplified denoviose-coumarins related to novobiocin as potent inhibitors of heat-shock protein 90 (hsp90).

27 September 2018

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Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90: evidence that coumarin antibiotics disrupt Hsp90 dimerization

27 September 2018

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Synthesis of (-)-noviose from 2,3-O-isopropylidene-D-erythronolactol

27 September 2018

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Hsp90 isoforms: functions, expression and clinical importance

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164572

The 43-kilodalton N-terminal fragment of the DNA gyrase B protein hydrolyzes ATP and binds coumarin drugs.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164572

Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21553822

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

How important is the N-3 sugar moiety in the tight-binding interaction of coformycin with adenosine deaminase?

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21553822

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Synthesis and evaluation of coumermycin A1 analogues that inhibit the Hsp90 protein folding machinery

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21553822

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JM200148P

1 reference

7 August 2017

1 reference

7 August 2017

1 reference