Toll-like receptor signaling (Q35189960)

7 August 2017

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title

Toll-like receptor signaling. (English)

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7 August 2017

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Shizuo Akira

1

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PubMed ID

12893815

7 August 2017

language of work or name

English

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publication date

30 July 2003

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Journal of Biological Chemistry

7 August 2017

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7 August 2017

278

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7 August 2017

38105-38108

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7 August 2017

40

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Toll-like receptors: critical proteins linking innate and acquired immunity

7 August 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Toll-like receptors in the induction of the innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Innate immune recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

IRAK: a kinase associated with the interleukin-1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Distinct molecular mechanism for initiating TRAF6 signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Pyogenic bacterial infections in humans with IRAK-4 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

IRAK-M is a negative regulator of Toll-like receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

TRAF6 is a signal transducer for interleukin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Negative regulation of toll-like receptor-mediated signaling by Tollip

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Cutting edge: mouse pellino-2 modulates IL-1 and lipopolysaccharide signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

IRF3 mediates a TLR3/TLR4-specific antiviral gene program

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

TIRAP: an adapter molecule in the Toll signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R300028200

21 January 2018

Identifiers

DOI

10.1074/JBC.R300028200

1 reference

7 August 2017

1 reference

PubMed ID

12893815