On the significance of the role of cellular stress response reactions in the toxic actions of dioxin (Q35195331)

7 August 2017

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title

On the significance of the role of cellular stress response reactions in the toxic actions of dioxin (English)

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7 August 2017

Fumio Matsumura

1

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PubMed ID

12906918

7 August 2017

language of work or name

English

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publication date

1 August 2003

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7 August 2017

Biochemical Pharmacology

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7 August 2017

66

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7 August 2017

4

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7 August 2017

527-540

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2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

7 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Genetic and molecular aspects of 2,3,7,8-tetrachlorodibenzo-p-dioxin action

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Subcellular localization of the aryl hydrocarbon receptor is modulated by the immunophilin homolog hepatitis B virus X-associated protein 2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

The role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon receptor action

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Oxidative stress induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin is mediated by the aryl hydrocarbon (Ah) receptor complex.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Induction of cellular oxidative stress by aryl hydrocarbon receptor activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Oxidative stress in female B6C3F1 mice following acute and subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Sustained increase in intracellular free calcium and activation of cyclooxygenase-2 expression in mouse hepatoma cells treated with dioxin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Induction of human prostaglandin endoperoxide H synthase-2 (PHS-2) mRNA by TCDD.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Regulation of prostaglandin endoperoxide H synthase-2 induction by dioxin in rat hepatocytes: possible c-Src-mediated pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Modulation of prostaglandin H synthase-2 mRNA expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Induction of cyclooxygenase expression and enhancement of malignant cell transformation by 2,3,7,8-tetrachlorodibenzo-p-dioxin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Cytokines (IL-1beta and TNFalpha) in relation to biochemical and immunological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

2,3,7,8-Tetrachlorodibenzo-p-dioxin increases mRNA levels for interleukin-1beta, urokinase plasminogen activator, and tumor necrosis factor-alpha in human uterine endometrial adenocarcinoma RL95-2 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Cell-specific differences in the susceptibility of potential cellular targets of human origin derived from blood and lung following treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Non-carcinogenic effects of TCDD in animals.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Activation of transcription factors activator protein-1 and nuclear factor-kappaB by 2,3,7,8-tetrachlorodibenzo-p-dioxin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Enzyme induction by L-buthionine (S,R)-sulfoximine in cultured mouse hepatoma cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Cytotoxic response profiles of cultured rat hepatocytes to selected aromatic hydrocarbons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Role of p53 tumor suppressor gene in the toxicity of TCDD, endrin, naphthalene, and chromium (VI) in liver and brain tissues of mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

LPS induction of gene expression in human monocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Molecular mechanisms of endotoxin activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Stress-activated protein kinases: activation, regulation and function.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Mechanical stress-initiated signal transductions in vascular smooth muscle cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Redox regulation of cellular signalling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

ERK-1/2 and p38 kinase oppositely regulate nitric oxide-induced apoptosis of chondrocytes in association with p53, caspase-3, and differentiation status

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

p53 activation in response to microtubule disruption is mediated by integrin-Erk signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Kinases: positive and negative regulators of apoptosis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

How important is the protein phosphorylation pathway in the toxic expression of dioxin-type chemicals?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

2,3,7,8-Tetrachlorodibenzo-p-dioxin suppresses apoptosis and leads to hyperphosphorylation of p53 in rat hepatocytes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) inhibits growth factor withdrawal-induced apoptosis in the human mammary epithelial cell line, MCF-10A.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Protective action of dehydroascorbic acid on the Ah receptor-dependent and receptor-independent induction of lipid peroxidation in adipose tissue of male guinea pig caused by TCDD administration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

The cellular response to p53: the decision between life and death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Stimulation of calcium uptake in cultured rat hippocampal neurons by 2,3,7,8-tetrachlorodibenzo-p-dioxin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Regulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) of the DNA binding activity of transcriptional factors via nuclear protein phosphorylation in guinea pig adipose tissue

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Effects of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on receptor binding of epidermal growth factor in the hepatic plasma membrane of rat, guinea pig, mouse, and hamster

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

2,3,7,8-Tetrachlorodibenzo-p-dioxin causes elevation of the levels of the protein tyrosine kinase pp60c-src

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

TCDD causes stimulation of c-ras expression in the hepatic plasma membranes in vivo and in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

A mechanistic model of effects of dioxin on gene expression in the rat liver.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

TCDD-mediated changes in hepatic epidermal growth factor receptor may be a critical event in the hepatocarcinogenic action of TCDD.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Regulation of gene expression and acceleration of differentiation in human keratinocytes by 2,3,7,8-tetrachlorodibenzo-p-dioxin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Mechanism of inhibition of MDA-MB-468 breast cancer cell growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the expression of EGF and/or TGF-alpha

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) modulates function of human luteinizing granulosa cells via cAMP signaling and early reduction of glucose transporting activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

2,3,7,8-Tetrachlorodibenzo-P-dioxin induced alterations in protein phosphorylation in guinea pig adipose tissue.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters pancreatic membrane tyrosine phosphorylation following acute treatment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Benzo(a)pyrene, but not 2,3,7,8-tetrachlorodibenzo-p-dioxin, alters cell adhesion proteins in human uterine RL95-2 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Epidermal growth factor receptor mediates stress-induced expression of its ligands in rat gastric epithelial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on growth factor expression in the human breast cancer cell line MCF-7.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Reduction of adipose tissue lipoprotein lipase activity as a result of in vivo administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin to the guinea pig.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Effects of src-deficiency on the expression of in vivo toxicity of TCDD in a strain of c-src knockout mice procured through six generations of backcrossings to C57BL/6 mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Reduction of hepatic phosphoenolpyruvate carboxykinase (PEPCK) activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is due to decreased mRNA levels

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Down-regulation by troglitazone of hepatic tumor necrosis factor-alpha and interleukin-6 mRNA expression in a murine model of non-insulin-dependent diabetes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

The role of TNFalpha and TNF receptors in obesity and insulin resistance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Endothelial cell adhesion molecule and PMNL response to inflammatory stimuli and AGE-modified fibronectin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Characterization of the hyperlipidemia in guinea pigs induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) causes reduction in the low density lipoprotein (LDL) receptor activities in the hepatic plasma membrane of the guinea pig and rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Inhibition of acute TCDD toxicity by treatment with anti-tumor necrosis factor antibody or dexamethasone

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced reduction of adenosine deaminase activity in vivo and in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Differential toxicities of TCDD in vivo among normal, c-src knockout, geldanamycin- and quercetin-treated mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Pharmacological interventions of cyanide-induced cytotoxicity and DNA damage in isolated rat thymocytes and their protective efficacy in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Quercetin inhibits hydrogen peroxide (H2O2)-induced NF-kappaB DNA binding activity and DNA damage in HepG2 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Dietary flavonoids, quercetin, luteolin and genistein, reduce oxidative DNA damage and lipid peroxidation and quench free radicals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Flavonoids from Koelreuteria henryi and other sources as protein-tyrosine kinase inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Drug-metabolizing enzymes in ligand-modulated transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Dioxins: model chemicals for assessing receptor-mediated toxicity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Aryl hydrocarbon receptor-dependent suppression by 2,3,7, 8-tetrachlorodibenzo-p-dioxin of IgM secretion in activated B cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Expression of Ah receptor (TCDD receptor) during human monocytic differentiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

The differentiation-related upregulation of aryl hydrocarbon receptor transcript levels is suppressed by retinoic acid

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

AP-2 gene expression and modulation by retinoic acid during keratinocyte differentiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Depletion of arylhydrocarbon receptor during adipose differentiation in 3T3-L1 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Metabolism-based polycyclic aromatic acetylene inhibition of CYP1B1 in 10T1/2 cells potentiates aryl hydrocarbon receptor activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

[Proteins in response to environmental stress]

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

[Heme metabolism in stress response]

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Activation of the Ah receptor signal transduction pathway by bilirubin and biliverdin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Induction of metallothionein in the livers of female Sprague-Dawley rats treated with 2,3,7 ,8-tetrachlorodibenzo-p-dioxin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Amelioration of TCDD-induced teratogenesis in aryl hydrocarbon receptor (AhR)-null mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) accelerates differentiation of murine preimplantation embryos in vitro.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Mechanism of suppression of cytochrome P-450 1A1 expression by tumor necrosis factor-alpha and lipopolysaccharide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Nutritional and metabolic effects of the endotoxin bacterial lipopolysaccharide in orally and parenterally fed rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Plasma interleukin-6, tumour necrosis factor alpha and blood cytokine production in type 2 diabetes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Modulation of nitric oxide synthase activity in macrophages

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Endotoxin-lipoprotein complex formation as a factor in atherogenesis: associations with hyperlipidemia and with lecithin:cholesterol acyltransferase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Effect of endotoxin and cytokines on lipoprotein lipase activity in mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Metallothionein induction in freshly isolated rat hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Decreased gluconeogenesis and increased glucose disposal without hyperinsulinemia in 10-day-old rats with endotoxic shock.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Regulation of prostanoid synthesis in microglial cells and effects of prostaglandin E2 on microglial functions.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Quercetin, coenzyme Q10, and L-canavanine as protective agents against lipid peroxidation and nitric oxide generation in endotoxin-induced shock in rat brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Acute inflammation induces hyporetinemia and modifies the plasma and tissue response to vitamin A supplementation in marginally vitamin A-deficient rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Endotoxins and endocrine system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Cytokines modulate glucose transport in skeletal muscle by inducing the expression of inducible nitric oxide synthase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Interferon γ Induces the Expression of p21waf-1 and Arrests Macrophage Cell Cycle, Preventing Induction of Apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

Down-regulation of liver and heart specific fatty acid binding proteins by endotoxin and cytokines in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900157-6

10.1016/S0006-2952(03)00157-6

7 January 2021

Identifiers

DOI

1 reference

7 August 2017

1 reference

PubMed ID

12906918