Gene therapy progress and prospects: Parkinson's disease (Q35206326)

7 August 2017

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title

Gene therapy progress and prospects: Parkinson's disease (English)

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7 August 2017

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Burton EA

1

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7 August 2017

Glorioso JC

series ordinal

2

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7 August 2017

Fink DJ

series ordinal

3

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7 August 2017

publication date

1 September 2003

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7 August 2017

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7 August 2017

volume

10

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7 August 2017

issue

20

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7 August 2017

page(s)

1721-1727

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NAIP protects the nigrostriatal dopamine pathway in an intrastriatal 6-OHDA rat model of Parkinson's disease.

7 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Protection of nigral neurons by GDNF-engineered marrow cell transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Neuroprotective and restorative effects of intrastriatal grafting of encapsulated GDNF-producing cells in a rat model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Lentiviral vectors as a gene delivery system in the mouse midbrain: cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Bcl-2 and GDNF delivered by HSV-mediated gene transfer act additively to protect dopaminergic neurons from 6-OHDA-induced degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Subthalamic GAD gene therapy in a Parkinson's disease rat model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Correction of a Rat Model of Parkinson's Disease by Coexpression of Tyrosine Hydroxylase and Aromatic Amino Acid Decarboxylase from a Helper Virus-Free Herpes Simplex Virus Type 1 Vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Mutations in NR4A2 associated with familial Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

A Drosophila model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Development of a new treatment for Alzheimer's disease and Parkinson's disease using anti-aggregatory beta-synuclein-derived peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Regulators split on gene therapy as patient shows signs of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

AAV serotype 2 vectors preferentially integrate into active genes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Blinded positron emission tomography study of dopamine cell implantation for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Transplantation of embryonic dopamine neurons for severe Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

Grafting of encapsulated genetically modified cells secreting GDNF into the striatum of parkinsonian model rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

7 January 2021

Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

7 January 2021

Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

7 January 2021

Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

7 January 2021

Adeno-associated viral delivery of GDNF promotes recovery of dopaminergic phenotype following a unilateral 6-hydroxydopamine lesion.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

7 January 2021

Protection by synergistic effects of adenovirus-mediated X-chromosome-linked inhibitor of apoptosis and glial cell line-derived neurotrophic factor gene transfer in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

7 January 2021

Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302116

7 January 2021

Identifiers

DOI

10.1038/SJ.GT.3302116

1 reference

7 August 2017

1 reference