Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer. (Q35212727)

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2 March 2020

title

Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer (English)

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2 March 2020

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12

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Aaron N Hata

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29

Tyler Jacks

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2 March 2020

author name string

Anthony C Faber

1

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Anna F Farago

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Carlotta Costa

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Anahita Dastur

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Maria Gomez-Caraballo

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Rebecca Robbins

6

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Bethany L Wagner

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William M Rideout

8

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Charles T Jakubik

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Jungoh Ham

10

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Elena J Edelman

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Alan T Yeo

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Youngchul Song

15

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Neha U Patel

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Ryan J March

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Ah Ting Tam

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Randy J Milano

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Jessica L Boisvert

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Mark A Hicks

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Sarah Elmiligy

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Scott E Malstrom

23

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Miguel N Rivera

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Hisashi Harada

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Brad E Windle

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Sridhar Ramaswamy

27

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Cyril H Benes

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Jeffrey A Engelman

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language of work or name

English

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publication date

3 March 2015

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Proceedings of the National Academy of Sciences of the United States of America

2 March 2020

published in

1 reference

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volume

112

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issue

11

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2 March 2020

page(s)

E1288-96

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Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing

2 March 2020

cites work

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The BH3 mimetic ABT-263 synergizes with the MEK1/2 inhibitor selumetinib/AZD6244 to promote BIM-dependent tumour cell death and inhibit acquired resistance

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13 July 2018

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13 July 2018

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'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.

13 July 2018

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

13 July 2018

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Randomized phase III trial comparing irinotecan/cisplatin with etoposide/cisplatin in patients with previously untreated extensive-stage disease small-cell lung cancer

13 July 2018

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The impact of EGFR T790M mutations and BIM mRNA expression on outcome in patients with EGFR-mutant NSCLC treated with erlotinib or chemotherapy in the randomized phase III EURTAC trial

13 July 2018

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26 September 2018

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Cell of origin of small cell lung cancer: inactivation of Trp53 and Rb1 in distinct cell types of adult mouse lung.

26 September 2018

1 reference

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Subversion of the Bcl-2 life/death switch in cancer development and therapy.

26 September 2018

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Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines

26 September 2018

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Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25737542

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1411848112

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25737542%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

0 references

1 reference

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2 March 2020

PubMed publication ID

25737542

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25737542%20AND%20SRC:MED&resulttype=core&format=json