The solution structures of two human IgG1 antibodies show conformational stability and accommodate their C1q and FcγR ligands. (Q35221593)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25659433%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

title

The solution structures of two human IgG1 antibodies show conformational stability and accommodate their C1q and FcγR ligands (English)

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29 February 2020

5

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29 February 2020

author name string

Lucy E Rayner

1

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29 February 2020

Gar Kay Hui

2

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29 February 2020

Jayesh Gor

3

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29 February 2020

Richard K Heenan

4

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29 February 2020

Stephen J Perkins

6

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29 February 2020

language of work or name

English

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publication date

6 February 2015

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25659433%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

29 February 2020

published in

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29 February 2020

volume

290

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29 February 2020

issue

13

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29 February 2020

page(s)

8420-8438

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Immunoglobulin flexibility in complement activation.

29 February 2020

cites work

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13 July 2018

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13 July 2018

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13 July 2018

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The structure of a human type III Fcgamma receptor in complex with Fc

13 July 2018

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The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex

13 July 2018

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Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc

13 July 2018

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13 July 2018

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The Fab and Fc fragments of IgA1 exhibit a different arrangement from that in IgG: a study by X-ray and neutron solution scattering and homology modelling

13 July 2018

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13 July 2018

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IgG binding sites on human Fc gamma receptors

13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies.

13 July 2018

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Segmental flexibility and complement fixation of genetically engineered chimeric human, rabbit and mouse antibodies

13 July 2018

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Temperature and pH dependence of immunoglobulin G conformation

13 July 2018

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Solution structure of human and mouse immunoglobulin M by synchrotron X-ray scattering and molecular graphics modelling. A possible mechanism for complement activation

13 July 2018

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Role of inter-heavy and light chain disulfide bonds in the effector functions of human immunoglobulin IgG1.

13 July 2018

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The structure and function of immunoglobulin domains. II. The importance of interchain disulfide bonds and the possible role of molecular flexibility in the interaction between immunoglobulin G and complement

13 July 2018

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13 July 2018

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Assessment of naturally occurring covalent and total dimer levels in human IgG1 and IgG2.

13 July 2018

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26 September 2018

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26 September 2018

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26 September 2018

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26 September 2018

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26 September 2018

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26 September 2018

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26 September 2018

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26 September 2018

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26 September 2018

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26 September 2018

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21 January 2018

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Conformation of human IgG subclasses in solution. Small-angle X-ray scattering and hydrodynamic studies

21 January 2018

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Lysine 322 in the human IgG3 CH2 domain is crucial for antibody dependent complement activation

21 January 2018

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21 January 2018

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12 December 2020

Pentameric and decameric structures in solution of serum amyloid P component by X-ray and neutron scattering and molecular modelling analyses

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Semi-extended solution structure of human myeloma immunoglobulin D determined by constrained X-ray scattering

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Human Fc gamma RI and Fc gamma RII interact with distinct but overlapping sites on human IgG

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Identifiers

DOI

10.1074/JBC.M114.631002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25659433%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25659433%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

PubMed publication ID

25659433

1 reference