Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining. (Q35243380)

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16 February 2020

title

Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining (English)

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16 February 2020

12

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author name string

Hind Ghezraoui

1

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16 February 2020

Marion Piganeau

2

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16 February 2020

Benjamin Renouf

3

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16 February 2020

Jean-Baptiste Renaud

4

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16 February 2020

Annahita Sallmyr

5

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16 February 2020

Brian Ruis

6

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16 February 2020

Sehyun Oh

7

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Alan E Tomkinson

8

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16 February 2020

Eric A Hendrickson

9

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16 February 2020

Carine Giovannangeli

10

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Maria Jasin

11

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16 February 2020

publication date

4 September 2014

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16 February 2020

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16 February 2020

volume

55

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issue

6

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16 February 2020

page(s)

829-842

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DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cells

16 February 2020

cites work

1 reference

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Targeted genomic rearrangements using CRISPR/Cas technology

27 July 2018

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Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining

27 July 2018

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The clinical impact of deficiency in DNA non-homologous end-joining

27 July 2018

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Non-homologous end joining often uses microhomology: implications for alternative end joining

27 July 2018

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Replicative mechanisms for CNV formation are error prone

27 July 2018

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Modernizing the nonhomologous end-joining repertoire: alternative and classical NHEJ share the stage.

27 July 2018

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CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

27 July 2018

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High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

27 July 2018

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The repair and signaling responses to DNA double-strand breaks

27 July 2018

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ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

27 July 2018

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Cancer translocations in human cells induced by zinc finger and TALE nucleases

27 July 2018

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A noncatalytic function of the ligation complex during nonhomologous end joining

27 July 2018

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RNA-guided human genome engineering via Cas9

27 July 2018

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Multiplex genome engineering using CRISPR/Cas systems

27 July 2018

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Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks

27 July 2018

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A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

27 July 2018

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Terminal deoxynucleotidyl transferase requires KU80 and XRCC4 to promote N-addition at non-V(D)J chromosomal breaks in non-lymphoid cells

27 July 2018

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Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1)

27 July 2018

1 reference

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Characterization of complex chromosomal rearrangements by targeted capture and next-generation sequencing

27 July 2018

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DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation

27 July 2018

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An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway

27 July 2018

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Triggers for genomic rearrangements: insights into genomic, cellular and environmental influences

27 July 2018

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Genome editing with engineered zinc finger nucleases

27 July 2018

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Origin of chromosomal translocations in lymphoid cancer

27 July 2018

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Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4-ligase IV during chromosomal translocation formation

27 July 2018

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Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells

27 July 2018

1 reference

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Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70

27 July 2018

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Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer

27 July 2018

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Ku86 represses lethal telomere deletion events in human somatic cells

27 July 2018

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A microhomology-mediated break-induced replication model for the origin of human copy number variation

27 July 2018

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Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair

27 July 2018

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Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends

27 July 2018

1 reference

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Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70.

27 July 2018

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Low levels of DNA ligases III and IV sufficient for effective NHEJ.

27 July 2018

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The impact of translocations and gene fusions on cancer causation

27 July 2018

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A model of oncogenic rearrangements: differences between chromosomal translocation mechanisms and simple double-strand break repair

27 July 2018

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DNA ligase III as a candidate component of backup pathways of nonhomologous end joining

27 July 2018

1 reference

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Impact of DNA ligase IV on the fidelity of end joining in human cells

27 July 2018

1 reference

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An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells.

27 July 2018

1 reference

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DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency

27 July 2018

1 reference

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SCID in Jack Russell terriers: a new animal model of DNA-PKcs deficiency

27 July 2018

1 reference

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The C-terminal conserved domain of DNA-PKcs, missing in the SCID mouse, is required for kinase activity

27 July 2018

1 reference

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Absence of DNA ligase IV protein in XR-1 cells: evidence for stabilization by XRCC4.

27 July 2018

1 reference

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Fine structure of translocation breakpoints in leukemic blasts with chromosomal translocation t(4;11): the DNA damage-repair model of translocation

27 July 2018

1 reference

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DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes

27 July 2018

1 reference

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Chromosome translocation based on illegitimate recombination in human tumors

27 July 2018

1 reference

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Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

27 July 2018

1 reference

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Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

27 July 2018

1 reference

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Ku80-deficient cells exhibit excess degradation of extrachromosomal DNA.

27 July 2018

1 reference

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Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

27 July 2018

1 reference

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DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair

27 July 2018

1 reference

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Mechanisms of nonhomologous recombination in mammalian cells

27 July 2018

1 reference

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Is non-homologous end-joining really an inherently error-prone process?

27 July 2018

1 reference

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The potent oncogene NPM-ALK mediates malignant transformation of normal human CD4(+) T lymphocytes

26 September 2018

1 reference

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Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

26 September 2018

1 reference

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Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunction

26 September 2018

1 reference

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The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

26 September 2018

1 reference

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Chromosomal translocations induced at specified loci in human stem cells.

26 September 2018

1 reference

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Microhomologies and interspersed repeat elements at genomic breakpoints in chronic myeloid leukemia.

26 September 2018

1 reference

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Analysis of t(9;11) chromosomal breakpoint sequences in childhood acute leukemia: almost identical MLL breakpoints in therapy-related AML after treatment without etoposides

26 September 2018

1 reference

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Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations.

26 September 2018

1 reference

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Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia.

26 September 2018

1 reference

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Ku86 is essential in human somatic cells

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398060

A DNA damage repair mechanism is involved in the origin of chromosomal translocations t(4;11) in primary leukemic cells

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398060

Double-strand break repair in Ku86- and XRCC4-deficient cells

26 September 2018

1 reference

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10.1016/J.MOLCEL.2014.08.002

26 September 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25201414%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25201414%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

PubMed publication ID

25201414

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25201414%20AND%20SRC:MED&resulttype=core&format=json