Role of Klotho in aging, phosphate metabolism, and CKD. (Q35318410)

7 August 2017

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title

Role of Klotho in aging, phosphate metabolism, and CKD. (English)

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7 August 2017

3

Makoto Kuro-o

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7 August 2017

George B John

1

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7 August 2017

Chung-Yi Cheng

series ordinal

2

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7 August 2017

language of work or name

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15 April 2011

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American Journal of Kidney Diseases

7 August 2017

published in

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7 August 2017

volume

58

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7 August 2017

issue

1

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7 August 2017

page(s)

127-134

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Klotho deficiency causes vascular calcification in chronic kidney disease

7 August 2017

cites work

1 reference

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Klotho deficiency is an early biomarker of renal ischemia–reperfusion injury and its replacement is protective

12 July 2018

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Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects

12 July 2018

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Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule

12 July 2018

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Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging

12 July 2018

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In vivo genetic evidence for suppressing vascular and soft-tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-dihydroxyvitamin d levels

12 July 2018

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Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease

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Circulating fibroblast growth factor 23 in patients with end-stage renal disease treated by peritoneal dialysis is intact and biologically active

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Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients.

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Klotho is a substrate for alpha-, beta- and gamma-secretase

12 July 2018

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Centenarians--a useful model for healthy aging? A 29-year follow-up of hospitalizations among 40,000 Danes born in 1905

12 July 2018

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Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse model

12 July 2018

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12 July 2018

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Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis

12 July 2018

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Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

12 July 2018

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12 July 2018

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Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers

12 July 2018

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Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system

12 July 2018

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12 July 2018

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In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage

12 July 2018

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Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23

12 July 2018

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

12 July 2018

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12 July 2018

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Limitations of creatinine as a filtration marker in glomerulopathic patients

12 July 2018

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12 July 2018

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Parathyroid Klotho and FGF-receptor 1 expression decline with renal function in hyperparathyroid patients with chronic kidney disease and kidney transplant recipients

12 July 2018

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Involvement of alpha-klotho and fibroblast growth factor receptor in the development of secondary hyperparathyroidism.

26 September 2018

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Regulation of fibroblast growth factor 23 production in bone in uremic rats.

26 September 2018

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Klotho in chronic kidney disease--what's new?

26 September 2018

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26 September 2018

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26 September 2018

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Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process

26 September 2018

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Relation between serum phosphate level and cardiovascular event rate in people with coronary disease

26 September 2018

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Klotho reduces apoptosis in experimental ischaemic acute renal failure

26 September 2018

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Klotho insufficiency causes decrease of ribosomal RNA gene transcription activity, cytoplasmic RNA and rough ER in the spinal anterior horn cells.

26 September 2018

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Clinical implications of estimating equations for glomerular filtration rate

26 September 2018

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26 September 2018

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Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides

26 September 2018

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Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress.

26 September 2018

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26 September 2018

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Age Changes in the Human Kidney of the Different Races

26 September 2018

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Association of elevated serum PO(4), Ca x PO(4) product, and parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients

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Role of hyperphosphatemia and 1,25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice

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Identifiers

DOI

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7 August 2017

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7 August 2017

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