Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage (Q35352915)

7 August 2017

title

Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage (English)

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7 August 2017

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C Chao

1

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7 August 2017

S Saito

2

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7 August 2017

C W Anderson

3

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7 August 2017

E Appella

4

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7 August 2017

Y Xu

5

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7 August 2017

language of work or name

English

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publication date

1 October 2000

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Proceedings of the National Academy of Sciences of the United States of America

7 August 2017

published in

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7 August 2017

volume

97

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7 August 2017

issue

22

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7 August 2017

page(s)

11936-11941

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describes a project that uses

7 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC17273/fullTextXML

inferred from PubMed Central ID database lookup

cites work

p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

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Signaling to p53: breaking the posttranslational modification code

12 July 2018

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

12 July 2018

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The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

12 July 2018

1 reference

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Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53

12 July 2018

1 reference

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Mechanisms of switching on p53: a role for covalent modification?

12 July 2018

1 reference

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Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

12 July 2018

1 reference

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Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

12 July 2018

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DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage

12 July 2018

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12 July 2018

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DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

12 July 2018

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DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

12 July 2018

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Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

12 July 2018

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Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks

12 July 2018

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Regulation of p53 function and stability by phosphorylation

12 July 2018

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A role for ATR in the DNA damage-induced phosphorylation of p53

12 July 2018

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p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

12 July 2018

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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

12 July 2018

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DNA damage activates p53 through a phosphorylation-acetylation cascade

12 July 2018

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

12 July 2018

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

12 July 2018

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ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage

12 July 2018

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12 July 2018

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DNA damage induces phosphorylation of the amino terminus of p53

12 July 2018

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

12 July 2018

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The ATM gene and protein: possible roles in genome surveillance, checkpoint controls and cellular defence against oxidative stress

12 July 2018

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Regulation of ES cell differentiation by functional and conformational modulation of p53.

12 July 2018

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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

12 July 2018

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Deletion of the Ig kappa light chain intronic enhancer/matrix attachment region impairs but does not abolish V kappa J kappa rearrangement

12 July 2018

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Mutation of the serine 15 phosphorylation site of human p53 reduces the ability of p53 to inhibit cell cycle progression.

12 July 2018

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Analysis of the gene coding for the murine cellular tumour antigen p53

12 July 2018

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

12 July 2018

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Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17273

Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.

12 July 2018

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26 September 2018

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Serine phosphorylation in the NH2 terminus of p53 facilitates transactivation

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11035798

12 December 2020

inferred from PubMed ID database lookup

Phosphorylation of p53 serine 15 increases interaction with CBP

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11035798

12 December 2020

inferred from PubMed ID database lookup

P53-dependent and -independent links between DNA-damage, apoptosis and mutation frequency in ES cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11035798

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.220252297

1 reference

7 August 2017

0 references

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7 August 2017

1 reference