CYLD Regulates Noscapine Activity in Acute Lymphoblastic Leukemia via a Microtubule-Dependent Mechanism. (Q35475874)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25897332%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

title

CYLD Regulates Noscapine Activity in Acute Lymphoblastic Leukemia via a Microtubule-Dependent Mechanism (English)

1 reference

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6 March 2020

main subject

lymphoblastic leukemia

1 reference

Yunfan Yang

1

1 reference

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6 March 2020

Jie Ran

2

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6 March 2020

Lei Sun

3

1 reference

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6 March 2020

Xiaodong Sun

4

1 reference

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6 March 2020

Youguang Luo

5

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6 March 2020

Bing Yan

6

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6 March 2020

Tala

7

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6 March 2020

Dengwen Li

9

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6 March 2020

Lei Zhang

10

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6 March 2020

Gang Bao

11

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6 March 2020

publication date

2 March 2015

1 reference

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6 March 2020

number of pages

11

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inferred from page(s)

published in

Theranostics

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6 March 2020

volume

5

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6 March 2020

issue

7

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6 March 2020

page(s)

656-666

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25897332%20AND%20SRC:MED&resulttype=core&format=json

CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6.

6 March 2020

cites work

1 reference

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Microtubule-associated protein Mdp3 promotes breast cancer growth and metastasis

12 July 2018

1 reference

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End-binding protein 1 stimulates paclitaxel sensitivity in breast cancer by promoting its actions toward microtubule assembly and stability

12 July 2018

1 reference

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CYLD coordinates with EB1 to regulate microtubule dynamics and cell migration

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402491

CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation

12 July 2018

1 reference

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Acute lymphoblastic leukaemia

12 July 2018

1 reference

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CYLD regulates RhoA activity by modulating LARG ubiquitination

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402491

MicroRNA and transcription factor co-regulatory network analysis reveals miR-19 inhibits CYLD in T-cell acute lymphoblastic leukemia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402491

Tumor Suppressor Function of CYLD in Nonmelanoma Skin Cancer

12 July 2018

1 reference

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Microtubule-binding protein CLIP-170 is a mediator of paclitaxel sensitivity

12 July 2018

1 reference

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CYLD: a deubiquitination enzyme with multiple roles in cancer.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402491

The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402491

Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402491

CYLD regulates angiogenesis by mediating vascular endothelial cell migration

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402491

CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402491

CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402491

Parkin regulates paclitaxel sensitivity in breast cancer via a microtubule-dependent mechanism

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402491

The tumor suppressor CYLD regulates entry into mitosis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402491

Drug-resistant T-lymphoid tumors undergo apoptosis selectively in response to an antimicrotubule agent, EM011.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402491

Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402491

Microtubule-associated protein tau: a marker of paclitaxel sensitivity in breast cancer

12 July 2018

1 reference

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Targeting microtubules for cancer chemotherapy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402491

Negative regulation of JNK signaling by the tumor suppressor CYLD.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402491

Noscapine crosses the blood-brain barrier and inhibits glioblastoma growth

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402491

Microtubules as a target for anticancer drugs

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402491

Paclitaxel-resistant human ovarian cancer cells undergo c-Jun NH2-terminal kinase-mediated apoptosis in response to noscapine

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402491

Noscapine inhibits tumor growth with little toxicity to normal tissues or inhibition of immune responses

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402491

Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells

12 July 2018

1 reference

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Clinical significance of down-regulated cylindromatosis gene in chronic lymphocytic leukemia.

12 July 2018

1 reference

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Dysregulation of TNFα-induced necroptotic signaling in chronic lymphocytic leukemia: suppression of CYLD gene by LEF1.

26 September 2018

1 reference

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Tumour suppressor CYLD is a negative regulator of the mitotic kinase Aurora-B.

26 September 2018

1 reference

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The tumor suppressor CYLD regulates microtubule dynamics and plays a role in cell migration.

26 September 2018

1 reference

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Synthesis and biological evaluation of a cyclic ether fluorinated noscapine analog.

26 September 2018

1 reference

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Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferation

26 September 2018

1 reference

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Minor alteration of microtubule dynamics causes loss of tension across kinetochore pairs and activates the spindle checkpoint

26 September 2018

1 reference

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Cellular proteolytic modification of tumor-suppressor CYLD is critical for the initiation of human T-cell acute lymphoblastic leukemia

26 September 2018

1 reference

12 December 2020

Comparative bioavailability and pharmacokinetics of noscapine hydrogen embonate and noscapine hydrochloride

1 reference

12 December 2020

Rational design, synthesis and biological evaluations of amino-noscapine: a high affinity tubulin-binding noscapinoid

1 reference

12 December 2020

Noscapine and analogues as potential chemotherapeutic agents

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12 December 2020

Identifiers

DOI

10.7150/THNO.10844

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25897332%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25897332%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

PubMed publication ID

25897332

1 reference