Protein kinase Cα as a heart failure therapeutic target (Q35480691)

8 August 2017

Protein kinase Cα as a heart failure therapeutic target (English)

1 reference

8 August 2017

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Jeffery D Molkentin

2

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author name string

Qinghang Liu

series ordinal

1

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8 August 2017

16 October 2010

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Journal of Molecular and Cellular Cardiology

8 August 2017

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8 August 2017

51

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8 August 2017

4

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8 August 2017

474-478

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G alpha(q)-mediated activation of GRK2 by mechanical stretch in cardiac myocytes: the role of protein kinase C.

8 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

Chronic heart failure: contemporary diagnosis and management

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

Protein kinase C alpha and epsilon phosphorylation of troponin and myosin binding protein C reduce Ca2+ sensitivity in human myocardium

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

Protein kinase C isoforms differentially phosphorylate Ca(v)1.2 alpha(1c).

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

Protein kinase C in heart failure: a therapeutic target?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

PKCalpha regulates platelet granule secretion and thrombus formation in mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

The PKC inhibitor AEB071 may be a therapeutic option for psoriasis.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

PKC isozymes in chronic cardiac disease: possible therapeutic targets?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

Effect of ruboxistaurin in patients with diabetic macular edema: thirty-month results of the randomized PKC-DMES clinical trial

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

Convergence of protein kinase C and JAK-STAT signaling on transcription factor GATA-4.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

Protein kinase cascades in the regulation of cardiac hypertrophy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

Genetic and phenotypic targeting of beta-adrenergic signaling in heart failure

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

PKC-alpha regulates cardiac contractility and propensity toward heart failure

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

Manipulating cardiac contractility in heart failure: data from mice and men.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

Protein Kinase Cα Negatively Regulates Systolic and Diastolic Function in Pathological Hypertrophy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

Protein kinase C isoform-selective signals that lead to cardiac hypertrophy and the progression of heart failure

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin T

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

Long-term expression of protein kinase C in adult mouse hearts improves postischemic recovery

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

Ischemic preconditioning induces selective translocation of protein kinase C isoforms epsilon and eta in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

Involvement of phosphorylation in doxorubicin-mediated myofibril degeneration. An immunofluorescence microscopy analysis.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

Tissue-specific developmental regulation of protein kinase C isoforms.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

PKCbeta modulates ischemia-reperfusion injury in the heart

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

PICOT inhibits cardiac hypertrophy and enhances ventricular function and cardiomyocyte contractility

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

Differential regulation of cardiac protein kinase C isozyme expression after aortic banding in rat.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204459

Protein kinase C contains a pseudosubstrate prototope in its regulatory domain

26 September 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2010.10.004

Enhanced PKC beta II translocation and PKC beta II-RACK1 interactions in PKC epsilon-induced heart failure: a role for RACK1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2010.10.004

Ischemic Preconditioning Induces Selective Translocation of Protein Kinase C Isoforms and in the Heart of Conscious Rabbits Without Subcellular Redistribution of Total Protein Kinase C Activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2010.10.004

Increased protein kinase C and isozyme redistribution in pressure-overload cardiac hypertrophy in the rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2010.10.004

PKC translocation without changes in Galphaq and PLC-beta protein abundance in cardiac hypertrophy and failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2010.10.004

Calcineurin Promotes Protein Kinase C and c-Jun NH2-terminal Kinase Activation in the Heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2010.10.004

Alterations in protein kinase C isoenzyme expression and autophosphorylation during the progression of pressure overload-induced left ventricular hypertrophy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2010.10.004

Protein kinase C in the human heart: differential regulation of the isoforms in aortic stenosis or dilated cardiomyopathy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2010.10.004

Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2010.10.004

Genetic and phenotypic targeting of β-adrenergic signaling in heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2010.10.004

Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2010.10.004

Increased contractility and altered Ca(2+) transients of mouse heart myocytes conditionally expressing PKCbeta

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2010.10.004

PKC-betaII sensitizes cardiac myofilaments to Ca2+ by phosphorylating troponin I on threonine-144

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2010.10.004

Inhibition of protein kinase C reduces left ventricular fibrosis and dysfunction following myocardial infarction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2010.10.004

Inhibition of protein kinase C-beta by ruboxistaurin preserves cardiac function and reduces extracellular matrix production in diabetic cardiomyopathy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2010.10.004

Calcineurin promotes protein kinase C and c-Jun NH2-terminal kinase activation in the heart. Cross-talk between cardiac hypertrophic signaling pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2010.10.004

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.YJMCC.2010.10.004

1 reference

8 August 2017

1 reference

8 August 2017

1 reference

PubMed ID

20937286