DNA repair: from genome maintenance to biomarker and therapeutic target (Q35555880)

8 August 2017

1 reference

title

DNA repair: from genome maintenance to biomarker and therapeutic target (English)

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8 August 2017

0 references

1

Shadia Jalal

1 reference

8 August 2017

Jennifer N Earley

2

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8 August 2017

John J Turchi

series ordinal

3

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8 August 2017

language of work or name

English

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publication date

9 September 2011

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8 August 2017

published in

Clinical Cancer Research

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8 August 2017

volume

17

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8 August 2017

issue

22

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8 August 2017

page(s)

6973-6984

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Iniparib plus chemotherapy in metastatic triple-negative breast cancer

8 August 2017

cites work

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12 July 2018

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12 July 2018

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Prospective analysis of DNA damage and repair markers of lung cancer risk from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial

12 July 2018

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PARP-1 Regulates Chromatin Structure and Transcription through a KDM5B-Dependent Pathway

12 July 2018

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12 July 2018

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A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer

12 July 2018

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Rapid method for determination of DNA repair capacity in human peripheral blood lymphocytes amongst smokers

12 July 2018

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Poly(ADP-ribose) polymerase inhibitors as promising cancer therapeutics

12 July 2018

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12 July 2018

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12 July 2018

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Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.

12 July 2018

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Focus on histone variant H2AX: to be or not to be.

12 July 2018

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Downregulation of XPF-ERCC1 enhances cisplatin efficacy in cancer cells.

12 July 2018

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Targeted inhibition of Replication Protein A reveals cytotoxic activity, synergy with chemotherapeutic DNA-damaging agents, and insight into cellular function

12 July 2018

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Aprataxin tumor levels predict response of colorectal cancer patients to irinotecan-based treatment.

12 July 2018

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Genomic instability--an evolving hallmark of cancer

12 July 2018

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gammaH2AX: a sensitive molecular marker of DNA damage and repair

12 July 2018

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Reduced DNA repair capacity for removing tobacco carcinogen-induced DNA adducts contributes to risk of head and neck cancer but not tumor characteristics

12 July 2018

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The preclinical pharmacology and therapeutic activity of the novel CHK1 inhibitor SAR-020106.

12 July 2018

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Unsuitability of lymphoblastoid cell lines as surrogate of cryopreserved isolated lymphocytes for the analysis of DNA double-strand break repair activity.

12 July 2018

1 reference

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Dealing with DNA damage: relationships between checkpoint and repair pathways

12 July 2018

1 reference

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Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue.

12 July 2018

1 reference

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Differences in repair of DNA cross-links between lymphocytes and epithelial tumor cells from colon cancer patients measured in vitro with the comet assay

12 July 2018

1 reference

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Ku86 represses lethal telomere deletion events in human somatic cells

12 July 2018

1 reference

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Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Non-small cell lung cancer exhibits transcript overexpression of genes associated with homologous recombination and DNA replication pathways

12 July 2018

1 reference

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DNA repair in mammalian cells: Transcription-coupled DNA repair: directing your effort where it's most needed

12 July 2018

1 reference

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Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining

12 July 2018

1 reference

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DNA repair phenotype and cancer susceptibility--a mini review

12 July 2018

1 reference

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Fanconi anemia proteins stabilize replication forks

12 July 2018

1 reference

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Differences and evolution of the methods for the assessment of microsatellite instability

12 July 2018

1 reference

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Targeted therapy for cancer using PARP inhibitors

12 July 2018

1 reference

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DNA damage and repair capacity in patients with lung cancer: prediction of multiple primary tumors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

ATR: an essential regulator of genome integrity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Chromosome instability and risk of squamous cell carcinomas of head and neck

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Cytotoxicity and mutagenicity of endogenous DNA base lesions as potential cause of human aging

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

DNA repair pathways as targets for cancer therapy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Eukaryotic nucleotide excision repair: from understanding mechanisms to influencing biology

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Targeted cancer therapies based on the inhibition of DNA strand break repair

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Repair capacity for UV light induced DNA damage associated with risk of nonmelanoma skin cancer and tumor progression

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

DNA strand break repair and human genetic disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

ERCC1 as a risk stratifier in platinum-based chemotherapy for nonsmall-cell lung cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Mutagen sensitivity: a genetic predisposition factor for cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Interplay between mutagen sensitivity and epidemiological factors in modulatinglung cancer risk.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Mutagen sensitivity and neoplastic progression in patients with Barrett's esophagus: a prospective analysis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

DNA repair pathways in clinical practice: lessons from pediatric cancer susceptibility syndromes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

O6-methylguanine-DNA methyltransferase expression strongly correlates with outcome in childhood malignant gliomas: results from the CCG-945 Cohort

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

In vitro sensitivity to ultraviolet B light and skin cancer risk: a case-control analysis

12 July 2018

1 reference

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The concept of synthetic lethality in the context of anticancer therapy

12 July 2018

1 reference

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The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

MGMT gene silencing and benefit from temozolomide in glioblastoma

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Development of a high-throughput screen for inhibitors of replication protein A and its role in nucleotide excision repair.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Human severe combined immune deficiency and DNA repair

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Recognition and repair of DNA-cisplatin adducts

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Sensitivity to benzo(a)pyrene diol-epoxide associated with risk of breast cancer in young women and modulation by glutathione S-transferase polymorphisms: a case-control study.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: a molecular epidemiologic study

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Linking DNA damage and neurodegeneration

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Nucleotide excision repair and human syndromes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

12 July 2018

The Hallmarks of Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Genetic susceptibility to non-polyposis colorectal cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Assembly, subunit composition, and footprint of human DNA repair excision nuclease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Reduced DNA repair capacity in lung cancer patients

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Mutagen sensitivity as a biological marker of lung cancer risk in African Americans.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Development and field-test validation of an assay for DNA repair in circulating human lymphocytes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Comet sensitivity in assessing DNA damage and repair in different cell cycle stages.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Colorectal cancer in HNPCC: cumulative lifetime incidence, survival and tumour distribution. A report of 121 families with proven mutations.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Reliability of mutagen sensitivity assay: an inter-laboratory comparison.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

The overexpression of specialized DNA polymerases in cancer.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Smoking, DNA repair capacity and risk of nonsmall cell lung cancer

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

A homozygous germ-line mutation in the human MSH2 gene predisposes to hematological malignancy and multiple café-au-lait spots

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Reduced DNA Repair Capacity in Laryngeal Cancer Subjects

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218201

Joint effect of mutagen sensitivity and insulin-like growth factors in predicting the risk of developing secondary primary tumors and tumor recurrence in patients with head and neck cancer

7 December 2018

1 reference

12 December 2020

Reduced DNA repair capacity in head and neck cancer patients

1 reference

12 December 2020

Impact of nicotinamide on human tumour hypoxic fraction measured using the comet assay

1 reference

12 December 2020

Human MLH1 deficiency predisposes to hematological malignancy and neurofibromatosis type 1

1 reference

12 December 2020

Validation of a fully automated COMET assay: 1.75 million single cells measured over a 5 year period

1 reference

12 December 2020

Rapid screening assay for mutagen sensitivity and DNA repair capacity in human peripheral blood lymphocytes

1 reference

12 December 2020

DNA repair: From molecular mechanism to human disease

1 reference

12 December 2020

ERCC1 and non-small-cell lung cancer

1 reference

12 December 2020

The comet assay: a method to measure DNA damage in individual cells

1 reference

12 December 2020

10.1158/1078-0432.CCR-11-0761

Identifiers

DOI

1 reference

8 August 2017

1 reference

8 August 2017

1 reference