Medical Countermeasures for Radiation Exposure and Related Injuries: Characterization of Medicines, FDA-Approval Status and Inclusion into the Strategic National Stockpile. (Q35566671)

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scientific article published on June 2015

Language	Label	Description	Also known as
English	Medical Countermeasures for Radiation Exposure and Related Injuries: Characterization of Medicines, FDA-Approval Status and Inclusion into the Strategic National Stockpile.	scientific article published on June 2015

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25905522%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

2 references

Europe PubMed Central

1 December 2020

Medical Countermeasures for Radiation Exposure and Related Injuries: Characterization of Medicines, FDA-Approval Status and Inclusion into the Strategic National Stockpile (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25905522%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

radiation sickness

1 reference

1 December 2020

strategic reserve

1 reference

PubMed publication ID

radiation protection agent

1 reference

1 December 2020

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25905522%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

author name string

Patricia L P Romaine

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25905522%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Thomas M Seed

3

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Europe PubMed Central

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6 March 2020

publication date

1 June 2015

4 references

19 June 2019

16 September 2019

Europe PubMed Central

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6 March 2020

1 December 2020

4 references

19 June 2019

16 September 2019

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25905522%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 December 2020

108

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Europe PubMed Central

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6 March 2020

6

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Europe PubMed Central

PMC publication ID

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6 March 2020

607-630

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Europe PubMed Central

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6 March 2020

copyright license

Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

1 reference

PMC publication ID

Colony-stimulating factors for the treatment of the hematopoietic component of the acute radiation syndrome (H-ARS): a review.

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Radioprotection of hematopoietic progenitors by low dose amifostine prophylaxis.

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ON01210.Na (Ex-RAD®) mitigates radiation damage through activation of the AKT pathway

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Epidermal growth factor regulates hematopoietic regeneration after radiation injury

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Insulin-like growth factor 1 mitigates hematopoietic toxicity after lethal total body irradiation

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Gamma-tocotrienol, a radiation prophylaxis agent, induces high levels of granulocyte colony-stimulating factor

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Dose-modifying factor for captopril for mitigation of radiation injury to normal lung

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Amelioration of radiation-induced hematopoietic and gastrointestinal damage by Ex-RAD(R) in mice

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5-AED enhances survival of irradiated mice in a G-CSF-dependent manner, stimulates innate immune cell function, reduces radiation-induced DNA damage and induces genes that modulate cell cycle progression and apoptosis

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Identification of granulocyte colony-stimulating factor and interleukin-6 as candidate biomarkers of CBLB502 efficacy as a medical radiation countermeasure

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The antioxidant tempol reduces carcinogenesis and enhances survival in mice when administered after nonlethal total body radiation.

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Prevention and mitigation of acute radiation syndrome in mice by synthetic lipopeptide agonists of Toll-like receptor 2 (TLR2)

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Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice

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HemaMax™, a recombinant human interleukin-12, is a potent mitigator of acute radiation injury in mice and non-human primates

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Calcium and zinc DTPA administration for internal contamination with plutonium-238 and americium-241.

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Oxidative stress mediates radiation lung injury by inducing apoptosis.

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Administration of ON 01210.Na after exposure to ionizing radiation protects bone marrow cells by attenuating DNA damage response

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A review of radiation countermeasure work ongoing at the Armed Forces Radiobiology Research Institute.

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Bactericidal/permeability-increasing protein (rBPI21) and fluoroquinolone mitigate radiation-induced bone marrow aplasia and death

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Reduction of Radiation-Induced Vascular Nitrosative Stress by the Vitamin E Analog γ-Tocotrienol: Evidence of a Role for Tetrahydrobiopterin

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History and development of radiation-protective agents

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Genistein protects against biomarkers of delayed lung sequelae in mice surviving high-dose total body irradiation

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Radiation protectants: current status and future prospects

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Medical treatment of radiological casualties: current concepts

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New drugs 05, part I.

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A sense of danger from radiation.

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Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group

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Management of postirradiation infection: lessons learned from animal models

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The hematologist and radiation casualties.

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Effectiveness of transfusions of fresh and lyophilized platelets in controlling bleeding due to thrombocytopenia

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The Strategic National Stockpile: roles and responsibilities of health care professionals for receiving the stockpile assets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

12 July 2018

Medical management principles for radiation accidents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

12 July 2018

Hematologic consequences of exposure to ionizing radiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

12 July 2018

Brief note and evaluation of acute-radiation syndrome and treatment of a Tokai-mura criticality accident patient

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

12 July 2018

The role of amifostine as a radioprotector.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

12 July 2018

In vivo radioprotection by 5-androstenediol: stimulation of the innate immune system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

12 July 2018

Amifostine: an update on its clinical status as a cytoprotectant in patients with cancer receiving chemotherapy or radiotherapy and its potential therapeutic application in myelodysplastic syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

12 July 2018

Androstenetriol and androstenediol. Protection against lethal radiation and restoration of immunity after radiation injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

12 July 2018

Androstenediol stimulates myelopoiesis and enhances resistance to infection in gamma-irradiated mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

12 July 2018

Health-related economic costs of the Three-Mile Island accident

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

12 July 2018

Pharmacologic approaches to protection against radiation-induced lethality and other damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

12 July 2018

Repair processes in radiation-induced transformation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

12 July 2018

Two Forms of Repair of DNA in Mammalian Cells following Irradiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

12 July 2018

Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

12 July 2018

The structure of an inhibitor of cholesterol biosynthesis isolated from barley.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

12 July 2018

Specific protection of different normal tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

12 July 2018

Pharmacokinetics of WR-2721.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

12 July 2018

Can WR-2721 be improved upon?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

12 July 2018

Recombinant interleukin-12, but not granulocyte-colony stimulating factor, improves survival in lethally irradiated nonhuman primates in the absence of supportive care: evidence for the development of a frontline radiation medical countermeasure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

26 September 2018

Genistein nanoparticles protect mouse hematopoietic system and prevent proinflammatory factors after gamma irradiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

26 September 2018

Radiation protection effect of rhIL-12 on monkey hematopoietic system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

26 September 2018

Enhanced hematopoietic protection from radiation by the combination of genistein and captopril.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

26 September 2018

Fibroblast growth factor-peptide promotes bone marrow recovery after irradiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

26 September 2018

Radioprotective effects of ON 01210.Na upon oral administration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

26 September 2018

α-Tocopherol succinate protects mice against radiation-induced gastrointestinal injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

26 September 2018

A TPO receptor agonist, ALXN4100TPO, mitigates radiation-induced lethality and stimulates hematopoiesis in CD2F1 mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

26 September 2018

Combined injury: factors with potential to impact radiation dose assessments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

26 September 2018

Effects of genistein administration on cytokine induction in whole-body gamma irradiated mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

26 September 2018

Genistein induces radioprotection by hematopoietic stem cell quiescence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

26 September 2018

Flagellin treatment protects against chemicals, bacteria, viruses, and radiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

26 September 2018

Strategic National Stockpile program: implications for military medicine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

26 September 2018

Effects of whole-body gamma irradiation and 5-androstenediol administration on serum G-CSF.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

26 September 2018

Induction of cytokines by radioprotective tocopherol analogs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

26 September 2018

Genistein stimulates hematopoiesis and increases survival in irradiated mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

26 September 2018

The therapeutic impacts of tocotrienols in type 2 diabetic patients with hyperlipidemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

26 September 2018

Molecular specificity of 5-androstenediol as a systemic radioprotectant in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

26 September 2018

Soy isoflavones suppress invasiveness of breast cancer cells by the inhibition of NF-kappaB/AP-1-dependent and -independent pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

26 September 2018

Genistein treatment protects mice from ionizing radiation injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

26 September 2018

Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

26 September 2018

Radioprotective efficacy and acute toxicity of 5-androstenediol after subcutaneous or oral administration in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

26 September 2018

Radioprotection, pharmacokinetic and behavioural studies in mouse implanted with biodegradable drug (amifostine) pellets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

26 September 2018

Behavioral toxicity of selected radioprotectors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

26 September 2018

Chemoprotection against Three Modes of Radiation Death in the Mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4418776

26 September 2018

Radioprotection by the histone deacetylase inhibitor phenylbutyrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/25905522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New therapy for the prevention and prophylactic treatment of acute radiation syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/25905522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subcutaneous administration of genistein prior to lethal irradiation supports multilineage, hematopoietic progenitor cell recovery and survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/25905522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CBLB613: A TLR 2/6 Agonist, Natural Lipopeptide ofMycoplasma arginini, as a Novel Radiation Countermeasure

1 reference

https://pubmed.ncbi.nlm.nih.gov/25905522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tocopherol succinate: modulation of antioxidant enzymes and oncogene expression, and hematopoietic recovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/25905522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Granulocyte colony-stimulating factor antibody abrogates radioprotective efficacy of gamma-tocotrienol, a promising radiation countermeasure

1 reference

https://pubmed.ncbi.nlm.nih.gov/25905522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of radiation-induced granulocyte colony-stimulating factor in recovery from whole body gamma-irradiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25905522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The regenerative ability of hemopoietic tissue following lethal x-irradiation in dogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/25905522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-activity relationships of topically active steroids: the selection of fluticasone propionate

1 reference

https://pubmed.ncbi.nlm.nih.gov/25905522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The treatment of the acute radiation syndrome in dogs with aureomycin and whole blood

1 reference

https://pubmed.ncbi.nlm.nih.gov/25905522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003

1 reference

https://pubmed.ncbi.nlm.nih.gov/25905522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pegfilgrastim administered in an abbreviated schedule, significantly improved neutrophil recovery after high-dose radiation-induced myelosuppression in rhesus macaques

1 reference

https://pubmed.ncbi.nlm.nih.gov/25905522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The FDA animal efficacy rule and biodefense

1 reference

https://pubmed.ncbi.nlm.nih.gov/25905522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo radioprotective effects of oltipraz in gamma-irradiated mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/25905522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Initial medical management of patients severely irradiated in the Tokai-mura criticality accident

1 reference

https://pubmed.ncbi.nlm.nih.gov/25905522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical trials of WR-2721 prior to alkylating agent chemotherapy and radiotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/25905522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radiation and a metalloporphyrin radioprotectant in a mouse prostate tumor model

1 reference

https://pubmed.ncbi.nlm.nih.gov/25905522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine in the treatment of head and neck cancer: intravenous administration, subcutaneous administration, or none of the above

1 reference

https://pubmed.ncbi.nlm.nih.gov/25905522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myeloid progenitors: a radiation countermeasure that is effective when initiated days after irradiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25905522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-Androstenediol promotes survival of gamma-irradiated human hematopoietic progenitors through induction of nuclear factor-kappaB activation and granulocyte colony-stimulating factor expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/25905522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1097/HP.0000000000000279

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25905522%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25905522%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25905522%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

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