UBR1 promotes protein kinase quality control and sensitizes cells to Hsp90 inhibition. (Q35566815)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21983172%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

title

UBR1 promotes protein kinase quality control and sensitizes cells to Hsp90 inhibition (English)

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14 February 2020

0 references

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ChEBI release 2020-05-28

2

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14 February 2020

author name string

Rasheda Sultana

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21983172%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

Avrom J Caplan

series ordinal

3

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14 February 2020

language of work or name

English

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publication date

29 September 2011

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21983172%20AND%20SRC:MED&resulttype=core&format=json

Experimental Cell Research

14 February 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21983172%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

volume

318

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14 February 2020

page(s)

53-60

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14 February 2020

issue

1

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The N-end rule pathway and regulation by proteolysis

14 February 2020

cites work

1 reference

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Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity

27 July 2018

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Targeting the dynamic HSP90 complex in cancer

27 July 2018

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Ubr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins

27 July 2018

1 reference

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Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway

27 July 2018

1 reference

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Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1

27 July 2018

1 reference

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Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase

27 July 2018

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Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

27 July 2018

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Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1.

27 July 2018

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Akt and CHIP coregulate tau degradation through coordinated interactions

27 July 2018

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Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin

27 July 2018

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CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70

27 July 2018

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Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome)

27 July 2018

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HSP90 and the chaperoning of cancer

27 July 2018

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A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons

27 July 2018

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CHIP (carboxyl terminus of Hsc70-interacting protein) promotes basal and geldanamycin-induced degradation of estrogen receptor-alpha

27 July 2018

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CHIP: a link between the chaperone and proteasome systems

27 July 2018

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CHIP activates HSF1 and confers protection against apoptosis and cellular stress

27 July 2018

1 reference

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A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

27 July 2018

1 reference

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Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

27 July 2018

1 reference

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Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

27 July 2018

1 reference

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The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

27 July 2018

1 reference

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DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90

27 July 2018

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Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1

27 July 2018

1 reference

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Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4

27 July 2018

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Adapting proteostasis for disease intervention

27 July 2018

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Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.

26 September 2018

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Formation of 17-allylamino-demethoxygeldanamycin (17-AAG) hydroquinone by NAD(P)H:quinone oxidoreductase 1: role of 17-AAG hydroquinone in heat shock protein 90 inhibition

26 September 2018

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C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation

26 September 2018

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Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy

26 September 2018

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The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

26 September 2018

1 reference

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Chaperone functions of the E3 ubiquitin ligase CHIP.

26 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.09.010

10.1016/J.YEXCR.2011.09.010

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21983172%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21983172%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference