PI3K/mTOR signaling regulates prostatic branching morphogenesis (Q35575601)

8 August 2017

title

PI3K/mTOR signaling regulates prostatic branching morphogenesis (English)

1 reference

8 August 2017

1 reference

7

David M Berman

1 reference

8 August 2017

Brian W Simons

3

0 references

Tamara L Lotan

8

object named as

Tamara L Lotan

1 reference

8 August 2017

6

Angelo M De Marzo

1 reference

8 August 2017

Susmita Ghosh

1

1 reference

8 August 2017

Hiu Lau

2

1 reference

8 August 2017

Jonathan D Powell

4

1 reference

8 August 2017

David J Meyers

5

1 reference

8 August 2017

language of work or name

English

0 references

publication date

8 October 2011

1 reference

8 August 2017

number of pages

14

1 reference

based on heuristic

inferred from page(s)

published in

Developmental Biology

1 reference

8 August 2017

volume

360

1 reference

8 August 2017

issue

2

1 reference

8 August 2017

page(s)

329-342

1 reference

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.

8 August 2017

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Control of HIF-1{alpha} and vascular signaling in fetal lung involves cross talk between mTORC1 and the FGF-10/FGFR2b/Spry2 airway branching periodicity clock.

12 July 2018

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12 July 2018

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A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration

12 July 2018

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mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging.

12 July 2018

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mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice

12 July 2018

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An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

12 July 2018

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mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization

12 July 2018

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Cell migration and activated PI3K/AKT-directed elongation in the developing rat Müllerian duct

12 July 2018

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Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis

12 July 2018

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TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

12 July 2018

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Androgen-induced programs for prostate epithelial growth and invasion arise in embryogenesis and are reactivated in cancer.

12 July 2018

1 reference

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The mTOR signaling network: insights from its role during embryonic development

12 July 2018

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Gene expression profiling in the developing prostate

12 July 2018

1 reference

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Molecular signaling pathways that regulate prostate gland development

12 July 2018

1 reference

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A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis

12 July 2018

1 reference

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The regulation of cell motility and chemotaxis by phospholipid signaling

12 July 2018

1 reference

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Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma

12 July 2018

1 reference

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A global double-fluorescent Cre reporter mouse

12 July 2018

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Defining the role of mTOR in cancer

12 July 2018

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Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl)pyrimido[2,1-alpha]isoquinolin-4-one

12 July 2018

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12 July 2018

The two TORCs and Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

12 July 2018

1 reference

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The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation

12 July 2018

1 reference

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Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability

12 July 2018

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Branching morphogenesis in the prostate gland and seminal vesicles

12 July 2018

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A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

12 July 2018

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

12 July 2018

1 reference

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

12 July 2018

1 reference

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Distinct regulatory elements mediate the dynamic expression pattern of Nkx3.1.

12 July 2018

1 reference

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Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

12 July 2018

1 reference

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Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice

12 July 2018

1 reference

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The role of Fgf10 signaling in branching morphogenesis and gene expression of the rat prostate gland: lobe-specific suppression by neonatal estrogens

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Bisperoxovanadium compounds are potent PTEN inhibitors.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Androgen receptor mediates non-genomic activation of phosphatidylinositol 3-OH kinase in androgen-sensitive epithelial cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Positive and Negative Roles of p85α and p85β Regulatory Subunits of Phosphoinositide 3-Kinase in Insulin Signaling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

FGF-10 plays an essential role in the growth of the fetal prostate

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Role of PI 3-kinase and PIP3 in submandibular gland branching morphogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Temporal and spatial regulation of chemotaxis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Ureteric bud outgrowth in response to RET activation is mediated by phosphatidylinositol 3-kinase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Role of androgens and fibroblast growth factors in prostatic development

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Prostatic growth and development are regulated by FGF10.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Roles for Nkx3.1 in prostate development and cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Fibroblast growth factor-10. A second candidate stromal to epithelial cell andromedin in prostate

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Differentiation of rat neonatal ventral prostates grown in a serum-free organ culture system

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Keratinocyte growth factor (KGF) can replace testosterone in the ductal branching morphogenesis of the rat ventral prostate.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Prostate-specific and androgen-dependent expression of a novel homeobox gene

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Substitution for mesenchyme by basement-membrane-like substratum and epidermal growth factor in inducing branching morphogenesis of mouse salivary epithelium

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

TSC1/2 tumour suppressor complex maintains Drosophila germline stem cells by preventing differentiation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

The pharmacology of mTOR inhibition

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Conserved gene expression programs integrate mammalian prostate development and tumorigenesis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Non-invasive visualization of the lipid product of class I PI3K in transgenic mouse models.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Fibroblast growth factor receptor signaling through MEK-ERK is required for prostate bud induction.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Growth, morphogenesis, and differentiation during mouse prostate development in situ, in renal grafts, and in vitro

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

PI3K-AKT pathway mediates growth and survival signals during development of fetal mouse lung

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

A noninvasive genetic/pharmacologic strategy for visualizing cell morphology and clonal relationships in the mouse.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

Tumor suppressor PTEN mediates sensing of chemoattractant gradients.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

PI(3)Kγ has an important context-dependent role in neutrophil chemokinesis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225010

The role of androgens in the epithelio-mesenchymal interactions involved in prostatic morphogenesis in embryonic mice

15 November 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.09.027

The possible influence of temporal factors in androgenic responsiveness of urogenital tissue recombinants from wild-type and androgen-insensitive (Tfm) mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.09.027

Primary culture of normal rat mammary epithelial cells within a basement membrane matrix. II. Functional differentiation under serum-free conditions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.09.027

A morphometric analysis of rat ventral prostate in organ culture

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.09.027

Analysis of prostatic bud induction by brief androgen treatment in the fetal rat urogenital sinus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.09.027

The culture of mature organs in a synthetic medium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.09.027

Branching morphogenesis of embryonic mouse lung epithelium in mesenchyme-free culture

7 January 2021

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22015718

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.YDBIO.2011.09.027

1 reference

8 August 2017

1 reference

8 August 2017

1 reference