Prognostic and predictive biomarkers in resected colon cancer: current status and future perspectives for integrating genomics into biomarker discovery (Q35583987)

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scientific article published on 29 March 2010

Language	Label	Description	Also known as
English	Prognostic and predictive biomarkers in resected colon cancer: current status and future perspectives for integrating genomics into biomarker discovery	scientific article published on 29 March 2010

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scholarly article

1 reference

Europe PubMed Central

9 August 2017

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25 November 2020

Prognostic and predictive biomarkers in resected colon cancer: current status and future perspectives for integrating genomics into biomarker discovery (English)

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Europe PubMed Central

9 August 2017

colorectal neoplasm

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25 November 2020

tumor biomarker

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7 August 2019

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25 November 2020

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based on heuristic

inferred from title

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based on heuristic

inferred from title

1

object named as

Sabine Tejpar

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Eric Van Cutsem

20

object named as

Eric Van Cutsem

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object named as

Roberto Fiocca

19

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Charles Swanton

object named as

Charles Swanton

16

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17

object named as

Ian Tomlinson

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Europe PubMed Central

9 August 2017

Levi A Garraway

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object named as

Levi Garraway

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Europe PubMed Central

9 August 2017

Monica Bertagnolli

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object named as

Monica Bertagnolli

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Europe PubMed Central

9 August 2017

author name string

Fred Bosman

3

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Europe PubMed Central

9 August 2017

Heinz-Joseph Lenz

4

1 reference

Europe PubMed Central

9 August 2017

Frederic Waldman

6

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Europe PubMed Central

9 August 2017

Robert Warren

7

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Europe PubMed Central

9 August 2017

Andrea Bild

8

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Europe PubMed Central

9 August 2017

Denise Collins-Brennan

9

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Europe PubMed Central

9 August 2017

Hejin Hahn

10

1 reference

Europe PubMed Central

9 August 2017

D Paul Harkin

11

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Europe PubMed Central

9 August 2017

Richard Kennedy

12

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Europe PubMed Central

9 August 2017

Mohammad Ilyas

13

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Europe PubMed Central

9 August 2017

Hans Morreau

14

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Europe PubMed Central

9 August 2017

Vitali Proutski

15

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9 August 2017

Mauro Delorenzi

18

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Europe PubMed Central

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Arnaud Roth

21

1 reference

Europe PubMed Central

9 August 2017

publication date

29 March 2010

6 references

Europe PubMed Central

9 August 2017

21 March 2019

3 April 2019

19 June 2019

7 August 2019

25 November 2020

6 references

Europe PubMed Central

9 August 2017

21 March 2019

3 April 2019

19 June 2019

7 August 2019

25 November 2020

15

1 reference

Europe PubMed Central

9 August 2017

4

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Europe PubMed Central

9 August 2017

390-404

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Europe PubMed Central

9 August 2017

Molecular origins of cancer: Molecular basis of colorectal cancer

1 reference

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KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 89803

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Tissue biomarker development in a multicentre trial context: a feasibility study on the PETACC3 stage II and III colon cancer adjuvant treatment trial

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Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial

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27 July 2018

Clinical implications of microsatellite instability in sporadic colon cancers

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27 July 2018

Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803.

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Deficient mismatch repair system in patients with sporadic advanced colorectal cancer

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Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer

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RNA expression analysis from formalin fixed paraffin embedded tissues

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Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer

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KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab.

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Biomarker discovery for colon cancer using a 761 gene RT-PCR assay.

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Colorectal carcinogenesis: road maps to cancer

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Interpretation of microarray data in cancer

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High-resolution copy number analysis of paraffin-embedded archival tissue using SNP BeadArrays.

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Colorectal cancer and genetic alterations in the Wnt pathway

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Chromosome 18q deletion and Smad4 protein inactivation correlate with liver metastasis: A study matched for T- and N- classification

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The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer

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Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer

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Concordance among gene-expression-based predictors for breast cancer

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Chromosomal instability, colorectal cancer and taxane resistance

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The complexity of p53 stabilization and activation

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Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis

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Oncogenic pathway signatures in human cancers as a guide to targeted therapies

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The TP53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation: influence of tumor site, type of mutation, and adjuvant treatment

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Global cancer statistics, 2002

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Array-based comparative genomic hybridization from formalin-fixed, paraffin-embedded breast tumors

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Systematic review of microsatellite instability and colorectal cancer prognosis

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Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging

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Ki-ras gene mutations, LOH of the APC and DCC genes, and microsatellite instability in primary colorectal carcinoma are not associated with micrometastases in pericolonic lymph nodes or with patients' survival

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A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels

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Pooled analysis of fluorouracil-based adjuvant therapy for stage II and III colon cancer: who benefits and by how much?

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Genomic instability and colon cancer

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Colon cancer survival is associated with increasing number of lymph nodes analyzed: a secondary survey of intergroup trial INT-0089.

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Prognostic significance of defective mismatch repair and BRAF V600E in patients with colon cancer.

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Progression and tumor heterogeneity analysis in early rectal cancer.

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Thymidylate synthase haplotype is associated with tumor recurrence in stage II and stage III colon cancer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

Phase III study comparing a semimonthly with a monthly regimen of fluorouracil and leucovorin as adjuvant treatment for stage II and III colon cancer patients: final results of GERCOR C96.1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

Frequent alteration of DNA damage signalling and repair pathways in human colorectal cancers with microsatellite instability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

Chromosomal instability in microsatellite-unstable and stable colon cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

Genomic signatures to guide the use of chemotherapeutics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

Diagnostic approach and management of Lynch syndrome (hereditary nonpolyposis colorectal carcinoma): a guide for clinicians

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

Relationships between promoter polymorphisms in the thymidylate synthase gene and mRNA levels in colorectal cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

SMAD4 levels and response to 5-fluorouracil in colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

Influence of thymidylate synthase gene polymorphisms on the survival of colorectal cancer patients receiving adjuvant 5-fluorouracil.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

Reporting recommendations for tumor marker prognostic studies (REMARK).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase protein expression on survival in adjuvantly treated stage III colon cancer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

Gene expression profiling of the irinotecan pathway in colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

P53 abnormalities and outcomes in colorectal cancer: a systematic review.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

Gene expression profiles and molecular markers to predict recurrence of Dukes' B colon cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

High-resolution analysis of DNA copy number alterations in colorectal cancer by array-based comparative genomic hybridization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression levels: predictors for survival in colorectal cancer patients receiving adjuvant 5-fluorouracil

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

Thymidylate synthase expression as a predictor of the prognosis of curatively resected colon carcinoma in patients registered in an adjuvant immunochemotherapy clinical trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

Prognostic value of thymidylate synthase, Ki-67, and p53 in patients with Dukes' B and C colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

Mutations at coding repeat sequences in mismatch repair-deficient human cancers: toward a new concept of target genes for instability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

Thymidylate synthase expression in colorectal cancer: a prognostic and predictive marker of benefit from adjuvant fluorouracil-based chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

p53 and Ki-ras as prognostic factors for Dukes' stage B colorectal cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

CpG island methylator phenotype in colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

p53 and thymidylate synthase expression in untreated stage II colon cancer: associations with recurrence, survival, and site.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

Confirmation that chromosome 18q allelic loss in colon cancer is a prognostic indicator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

K-ras and p16 aberrations confer poor prognosis in human colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

26 September 2018

p53 and K-ras gene mutations correlate with tumor aggressiveness but are not of routine prognostic value in colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

15 November 2018

High-throughput oncogene mutation profiling in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

15 November 2018

A prospective, blinded analysis of thymidylate synthase and p53 expression as prognostic markers in the adjuvant treatment of colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

15 November 2018

SMAD4 as a Prognostic Marker in Colorectal Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

15 November 2018

RAF/RAS oncogenes and mismatch-repair status

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227961

15 November 2018

Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: a Southwest Oncology Group study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20350999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allelic loss on chromosome 18q as a prognostic marker in stage II colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20350999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)

1 reference

https://pubmed.ncbi.nlm.nih.gov/20350999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microsatellite instability and 8p allelic imbalance in stage B2 and C colorectal cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/20350999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Poor Survival Associated with theBRAFV600E Mutation in Microsatellite-Stable Colon Cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/20350999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thymidylate synthase expression in colon carcinomas with microsatellite instability

1 reference

https://pubmed.ncbi.nlm.nih.gov/20350999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SMAD4/DPC4 expression and prognosis in human colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20350999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stage II colon cancer prognosis prediction by tumor gene expression profiling

1 reference

https://pubmed.ncbi.nlm.nih.gov/20350999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/20350999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between chromosome 18q status and colorectal cancer prognosis: a prospective, blinded analysis of 280 patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20350999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab

1 reference

https://pubmed.ncbi.nlm.nih.gov/20350999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Irinotecan fluorouracil plus leucovorin is not superior to fluorouracil plus leucovorin alone as adjuvant treatment for stage III colon cancer: results of CALGB 89803

1 reference

https://pubmed.ncbi.nlm.nih.gov/20350999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microsatellite instability in sporadic colon carcinomas has no independent prognostic value in a Belgian study population

1 reference

https://pubmed.ncbi.nlm.nih.gov/20350999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BRAFMutation in Metastatic Colorectal Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20350999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20350999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 gene mutation, microsatellite instability and adjuvant chemotherapy: impact on survival of 388 patients with Dukes' C colon carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20350999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The results of colorectal cancer treatment by p53 status: treatment-specific overview

1 reference

https://pubmed.ncbi.nlm.nih.gov/20350999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P53 alteration and microsatellite instability have predictive value for survival benefit from chemotherapy in stage III colorectal carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20350999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of mutated K12-ras in histologically negative lymph nodes as an indicator of poor prognosis in stage II colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20350999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/20350999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history

1 reference

https://pubmed.ncbi.nlm.nih.gov/20350999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allelic loss of chromosome 18q and prognosis in colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20350999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 point mutation and survival in colorectal cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20350999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1634/THEONCOLOGIST.2009-0233

1 reference

Europe PubMed Central

9 August 2017

1 reference

Europe PubMed Central

9 August 2017

1 reference

Europe PubMed Central

9 August 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

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Wikinews(0 entries)

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Wikiversity(0 entries)

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