Endothelial dysfunction in obesity and insulin resistance: a road to diabetes and heart disease (Q35588998)

9 August 2017

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title

Endothelial dysfunction in obesity and insulin resistance: a road to diabetes and heart disease (English)

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9 August 2017

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A Enrique Caballero

1

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PubMed ID

14627747

9 August 2017

language of work or name

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1 November 2003

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9 August 2017

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9 August 2017

11

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9 August 2017

1278-1289

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9 August 2017

11

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Prevalence and Trends in Obesity Among US Adults, 1999-2000

9 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

The obesity epidemic: pathophysiology and consequences of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Central role of the adipocyte in insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Adipokines, inflammation, and the endothelium in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Role of insulin resistance in human disease (syndrome X): an expanded definition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Atherosclerosis — An Inflammatory Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Pre-diabetes, insulin resistance, inflammation and CVD risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Obesity and risk of type 2 diabetes and cardiovascular disease in children and adolescents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Contributions of insulin-resistance and insulin-secretory defects to the pathogenesis of type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Endothelial function in health and disease: new insights into the genesis of cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Microvascular function in human diabetes. A physiological perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Soluble intercellular adhesion molecule, vascular cell adhesion molecule, and impaired microvascular reactivity are early markers of vasculopathy in type 2 diabetic individuals without microalbuminuria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Estrogen improves endothelial function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Impaired endothelium-dependent vasodilatation in women with previous gestational diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Early activation of vascular endothelium in nonobese, nondiabetic essential hypertensive patients with multiple metabolic abnormalities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Polycystic ovary syndrome is associated with endothelial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

The role of TNFalpha and TNF receptors in obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Direct antidiabetic effect of leptin through triglyceride depletion of tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

The hormone resistin links obesity to diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Vascular function, insulin resistance and fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Elevated serum TNF-alpha level as a link between endothelial dysfunction and insulin resistance in normotensive obese patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Inflammation and atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Hyperinsulinemia as an independent risk factor for ischemic heart disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Insulin sensitivity and atherosclerosis. The Insulin Resistance Atherosclerosis Study (IRAS) Investigators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Insulin action in vascular endothelium: potential mechanisms linking insulin resistance with hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Insulin signaling in the arterial wall

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Insulin causes endothelial dysfunction in humans: sites and mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Crosstalk between insulin and angiotensin II signalling systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Endothelial nitric oxide synthase gene is positively associated with essential hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Endothelial dysfunction: cause of the insulin resistance syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

The effect of weight loss with or without exercise training on large artery compliance in healthy obese men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Weight loss in combination with physical activity improves endothelial dysfunction in human obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Lifestyle modification improves endothelial function in obese subjects with the insulin resistance syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Unraveling the mechanism of action of thiazolidinediones

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Expression and function of PPARgamma in rat and human vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Control of vascular cell proliferation and migration by PPAR-gamma: a new approach to the macrovascular complications of diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Nonhypoglycemic effects of thiazolidinediones

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

The effects of troglitazone, an insulin-sensitizing agent, on the endothelial function in early and late type 2 diabetes: a placebo-controlled randomized clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Antiinflammatory and antiarteriosclerotic effects of pioglitazone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Metabolic and additional vascular effects of thiazolidinediones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Pioglitazone reduces urinary podocyte excretion in type 2 diabetes patients with microalbuminuria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Rosiglitazone reduces urinary albumin excretion in type II diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Decreased mortality associated with the use of metformin compared with sulfonylurea monotherapy in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

The effects of high- and medium-dose metformin therapy on cardiovascular risk factors in patients with type II diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Improved endothelial function with metformin in type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Effect of weight change and metformin on fibrinolysis and the von Willebrand factor in obese nondiabetic subjects: the BIGPRO1 Study. Biguanides and the Prevention of the Risk of Obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Insulin Sensitivity, Vascular Reactivity, and Clamp-Induced Vasodilatation in Essential Hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Overweight and obesity in the United States: prevalence and trends, 1960-1994

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Endothelial dysfunction in the early stage of atherosclerosis precedes appearance of intimal lesions assessable with intravascular ultrasound

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Reactive hyperemic response of the brachial artery: comparison of proximal and distal occlusion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Type II diabetes abrogates sex differences in endothelial function in premenopausal women

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Endothelial dysfunction is detectable in young normotensive first-degree relatives of subjects with type 2 diabetes in association with insulin resistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Relation of hypertriglyceridemia to plasma concentrations of biochemical markers of inflammation and endothelial activation (C-reactive protein, interleukin-6, soluble adhesion molecules, von Willebrand factor, and endothelin-1)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Leptin induces direct vasodilation through distinct endothelial mechanisms.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Relationship between endothelin-1 concentration and metabolic alterations typical of the insulin resistance syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Dissociation between insulin sensitivity of glucose uptake and endothelial function in normal subjects

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.174

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7 January 2021

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Identifiers

DOI

10.1038/OBY.2003.174

1 reference

9 August 2017

1 reference

PubMed ID

14627747