Clinical development of VEGF signaling pathway inhibitors in childhood solid tumors. (Q35599819)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22042784%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

Clinical development of VEGF signaling pathway inhibitors in childhood solid tumors (English)

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15 January 2020

1

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15 January 2020

author name string

Darrell J Yamashiro

series ordinal

2

1 reference

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15 January 2020

Elizabeth Fox

series ordinal

3

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15 January 2020

publication date

31 October 2011

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15 January 2020

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15 January 2020

volume

16

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15 January 2020

issue

11

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15 January 2020

page(s)

1614-1625

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Phase I and pharmacokinetic study of sunitinib in pediatric patients with refractory solid tumors: a children's oncology group study

15 January 2020

cites work

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Prospective analysis of the impact of VEGF-A gene polymorphisms on the pharmacodynamics of bevacizumab-based therapy in metastatic breast cancer patients

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27 July 2018

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27 July 2018

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27 July 2018

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PTHrP regulates angiogenesis and bone resorption via VEGF expression.

27 July 2018

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27 July 2018

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27 July 2018

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Plasma cytokine and angiogenic factor profiling identifies markers associated with tumor shrinkage in early-stage non-small cell lung cancer patients treated with pazopanib

27 July 2018

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27 July 2018

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Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2.

27 July 2018

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Cardiotoxicity of anticancer drugs: the need for cardio-oncology and cardio-oncological prevention

27 July 2018

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Clinical pharmacokinetics of tyrosine kinase inhibitors

27 July 2018

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Correlation between clinical outcome and growth factor pathway expression in osteogenic sarcoma

27 July 2018

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Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression

27 July 2018

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Cardiovascular toxicities: clues to optimal administration of vascular endothelial growth factor signaling pathway inhibitors

27 July 2018

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Combination of antiangiogenesis with chemotherapy for more effective cancer treatment

27 July 2018

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Phase I study of SU5416, a small molecule inhibitor of the vascular endothelial growth factor receptor (VEGFR) in refractory pediatric central nervous system tumors

27 July 2018

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Blood glucose levels in patients with metastatic renal cell carcinoma treated with sunitinib

27 July 2018

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Platelets, petechiae, and preservation of the vascular wall

27 July 2018

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VEGF165 is necessary to the metastatic potential of Fas(-) osteosarcoma cells but will not rescue the Fas(+) cells

27 July 2018

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Tyrosine kinase inhibitors and the thyroid as both an unintended and an intended target

27 July 2018

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Reversible skeletal changes after treatment with bevacizumab in a child with cutaneovisceral angiomatosis with thrombocytopenia syndrome

27 July 2018

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Initial testing (stage 1) of sunitinib by the pediatric preclinical testing program

27 July 2018

1 reference

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Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib

27 July 2018

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Prevention of postoperative progression of pulmonary metastases in osteosarcoma by antiangiogenic therapy using endostatin

27 July 2018

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Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity

27 July 2018

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Bevacizumab-induced transient remodeling of the vasculature in neuroblastoma xenografts results in improved delivery and efficacy of systemically administered chemotherapy

27 July 2018

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Blood-based biomarkers of SU11248 activity and clinical outcome in patients with metastatic imatinib-resistant gastrointestinal stromal tumor.

27 July 2018

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Safety, pharmacokinetics, and preliminary antitumor activity of sorafenib: a review of four phase I trials in patients with advanced refractory solid tumors

27 July 2018

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27 July 2018

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Initial testing of the VEGFR inhibitor AZD2171 by the pediatric preclinical testing program

27 July 2018

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An orally administered multitarget tyrosine kinase inhibitor, SU11248, is a novel potent inhibitor of thyroid oncogenic RET/papillary thyroid cancer kinases.

27 July 2018

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Review of the effects of anti-angiogenic compounds on the epiphyseal growth plate

27 July 2018

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Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer

27 July 2018

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Vascular endothelial growth factor acts in an autocrine manner in rhabdomyosarcoma cell lines and can be inhibited with all-trans-retinoic acid

27 July 2018

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VEGF-targeted therapy: therapeutic potential and recent advances

27 July 2018

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Antiangiogenic therapy for cancer: current and emerging concepts

27 July 2018

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AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer

27 July 2018

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A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model

27 July 2018

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A gene expression signature for relapse of primary wilms tumors

27 July 2018

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Vascular endothelial growth factor as a target for anticancer therapy

27 July 2018

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Hormonal Regulation and Functional Role of Vascular Endothelial Growth Factor A in the Rat Testis1

27 July 2018

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Regression of established tumors and metastases by potent vascular endothelial growth factor blockade

27 July 2018

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Expression and prognostic relevance of vascular endothelial growth factor (VEGF) and its receptor (FLT-1) in nephroblastoma.

27 July 2018

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ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases.

27 July 2018

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Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma

27 July 2018

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27 July 2018

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Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

27 July 2018

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27 July 2018

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Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor.

27 July 2018

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Expression of vascular endothelial growth factor (VEGF) and VEGF receptors in human neuroblastomas

27 July 2018

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VEGF receptor signaling in tumor angiogenesis

27 July 2018

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Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity

27 July 2018

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VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

27 July 2018

1 reference

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Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders

27 July 2018

1 reference

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Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure

27 July 2018

1 reference

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Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

27 July 2018

1 reference

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Tumor angiogenesis correlates with metastatic disease, N-myc amplification, and poor outcome in human neuroblastoma

27 July 2018

1 reference

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Tumor angiogenesis: therapeutic implications

27 July 2018

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Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

27 July 2018

1 reference

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Congestive heart failure risk in patients with breast cancer treated with bevacizumab.

27 July 2018

1 reference

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In vitro hepatic metabolism of cediranib, a potent vascular endothelial growth factor tyrosine kinase inhibitor: interspecies comparison and human enzymology.

26 September 2018

1 reference

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Sorafenib-induced hypothyroidism is associated with increased type 3 deiodination

26 September 2018

1 reference

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Initial assessment, surveillance, and management of blood pressure in patients receiving vascular endothelial growth factor signaling pathway inhibitors

26 September 2018

1 reference

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Sunitinib induces hypothyroidism with a markedly reduced vascularity

26 September 2018

1 reference

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Tyrosine kinase inhibitors and the thyroid.

26 September 2018

1 reference

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Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors

26 September 2018

1 reference

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Phase I trial of pazopanib in patients with advanced cancer.

26 September 2018

1 reference

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Sunitinib treatment in pediatric patients with advanced GIST following failure of imatinib.

26 September 2018

1 reference

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VEGF(165), but not VEGF(189), stimulates vasculogenesis and bone marrow cell migration into Ewing's sarcoma tumors in vivo.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233297

Phase I clinical study of AZD2171, an oral vascular endothelial growth factor signaling inhibitor, in patients with advanced solid tumors

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233297

Hypothyroidism after sunitinib treatment for patients with gastrointestinal stromal tumors.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233297

The pediatric preclinical testing program: description of models and early testing results.

26 September 2018

1 reference

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VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233297

Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumors

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233297

Intraovarian actions of anti-angiogenic agents disrupt periovulatory events during the menstrual cycle in monkeys

26 September 2018

1 reference

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Prognostic importance of comorbidity in a hospital-based cancer registry

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233297

Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233297

Vascular endothelial growth factor expression is up-regulated by EWS-ETS oncoproteins and Sp1 and may represent an independent predictor of survival in Ewing's sarcoma

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233297

An innovative phase I clinical study demonstrates inhibition of FLT3 phosphorylation by SU11248 in acute myeloid leukemia patients.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233297

Role of VEGF-A in vascularization of pancreatic islets

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233297

The biology of VEGF and its receptors

26 September 2018

1 reference

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Anti-VEGF antibody in experimental hepatoblastoma: suppression of tumor growth and altered angiogenesis

26 September 2018

1 reference

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SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo

26 September 2018

1 reference

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ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration.

26 September 2018

1 reference

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Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma

26 September 2018

1 reference

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Expression of angiogenic factors and tumor progression in human neuroblastoma.

26 September 2018

1 reference

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Are basic fibroblast growth factor and vascular endothelial growth factor prognostic indicators in pediatric patients with malignant solid tumors?

26 September 2018

1 reference

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Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability

26 September 2018

1 reference

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The mouse gene for vascular endothelial growth factor. Genomic structure, definition of the transcriptional unit, and characterization of transcriptional and post-transcriptional regulatory sequences.

26 September 2018

1 reference

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Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors

26 September 2018

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12 December 2020

Anti-VEGF antibody suppresses primary tumor growth and metastasis in an experimental model of Wilms' tumor

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12 December 2020

High-level expression of angiogenic factors is associated with advanced tumor stage in human neuroblastomas

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12 December 2020

The VIVA trial: Vascular endothelial growth factor in Ischemia for Vascular Angiogenesis

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12 December 2020

Tumor angiogenesis: transfilter diffusion studies in the hamster by the transparent chamber technique

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Antiangiogenic therapy: a universal chemosensitization strategy for cancer?

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12 December 2020

Clinical significance of Vascular Endothelial Growth Factor-A expression in Ewing's sarcoma

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12 December 2020

Local controlled intramyocardial delivery of platelet-derived growth factor improves postinfarction ventricular function without pulmonary toxicity

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12 December 2020

A Novel Tyrosine-Kinase Selective Inhibitor, Sunitinib, Induces Transient Hypothyroidism by Blocking Iodine Uptake

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12 December 2020

Phase I trial and pharmacokinetic study of bevacizumab in pediatric patients with refractory solid tumors: a Children's Oncology Group Study

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Concentration of vascular endothelial growth factor (VEGF) in the serum of patients with malignant bone tumors

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12 December 2020

Increased serum VEGF in 13 children with Wilms' tumour falls after surgery but rising levels predict poor prognosis

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Lack of early bevacizumab-related skeletal radiographic changes in children with neuroblastoma

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10.1634/THEONCOLOGIST.2011-0148

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22042784%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22042784%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference