Small-molecule agonists for the glucagon-like peptide 1 receptor (Q35612392)

9 August 2017

title

Small-molecule agonists for the glucagon-like peptide 1 receptor (English)

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9 August 2017

Lotte Bjerre Knudsen

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Jens Juul Holst

object named as

Jens J Holst

7

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Jesper Lau

22

object named as

Jesper Lau

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9 August 2017

Dan Kiel

2

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9 August 2017

Min Teng

3

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9 August 2017

Carsten Behrens

4

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9 August 2017

Dilip Bhumralkar

5

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9 August 2017

János T Kodra

6

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9 August 2017

Claus B Jeppesen

8

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9 August 2017

Michael D Johnson

9

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9 August 2017

Johannes Cornelis de Jong

10

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9 August 2017

Anker Steen Jorgensen

11

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9 August 2017

Tim Kercher

12

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9 August 2017

Jarek Kostrowicki

13

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9 August 2017

Peter Madsen

14

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9 August 2017

Preben H Olesen

15

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9 August 2017

Jacob S Petersen

16

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9 August 2017

Fritz Poulsen

17

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9 August 2017

Ulla G Sidelmann

18

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9 August 2017

Jeppe Sturis

19

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9 August 2017

Larry Truesdale

20

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9 August 2017

John May

21

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9 August 2017

language of work or name

English

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publication date

9 January 2007

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Proceedings of the National Academy of Sciences of the United States of America

9 August 2017

published in

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9 August 2017

volume

104

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9 August 2017

issue

3

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9 August 2017

page(s)

937-942

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Ago-allosteric modulation and other types of allostery in dimeric 7TM receptors

9 August 2017

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The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor

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One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes.

27 July 2018

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27 July 2018

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Allosteric modulation of G-protein coupled receptors.

27 July 2018

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Glucagon-like peptide-1 receptor is involved in learning and neuroprotection

27 July 2018

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Cardiac function in mice lacking the glucagon-like peptide-1 receptor

27 July 2018

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GPCR drug discovery through the exploitation of allosteric drug binding sites

27 July 2018

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Different domains of the glucagon and glucagon-like peptide-1 receptors provide the critical determinants of ligand selectivity

27 July 2018

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Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis

27 July 2018

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Identification of alkylidene hydrazides as glucagon receptor antagonists.

27 July 2018

1 reference

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Glucagon-like peptide-1 infusion must be maintained for 24 h/day to obtain acceptable glycemia in type 2 diabetic patients who are poorly controlled on sulphonylurea treatment

27 July 2018

1 reference

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Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration

27 July 2018

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Characterization of a novel nonpeptide vasopressin V(2)-agonist, OPC-51803, in cells transfected human vasopressin receptor subtypes

27 July 2018

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Activation of erythropoietin receptor in the absence of hormone by a peptide that binds to a domain different from the hormone binding site

27 July 2018

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Characterization of a novel, non-peptidyl antagonist of the human glucagon receptor

27 July 2018

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A small, nonpeptidyl mimic of granulocyte-colony-stimulating factor [see commetns].

27 July 2018

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Nonpeptide mimic of bradykinin with long-acting properties at the bradykinin B2 receptor

27 July 2018

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Activation of muscarinic acetylcholine receptors via their allosteric binding sites.

27 July 2018

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Discovery of 1,5-benzodiazepines with peripheral cholecystokinin (CCK-A) receptor agonist activity. 1. Optimization of the agonist "trigger".

27 July 2018

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A nonpeptidyl growth hormone secretagogue

27 July 2018

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Differentiation between binding sites for angiotensin II and nonpeptide antagonists on the angiotensin II type 1 receptors

27 July 2018

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Non-peptide angiotensin agonist. Functional and molecular interaction with the AT1 receptor.

27 July 2018

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Pathogenesis of NIDDM. A balanced overview

27 July 2018

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Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1

27 July 2018

1 reference

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The essential role of glucagon in the pathogenesis of diabetes mellitus

27 July 2018

1 reference

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The glucagon-like peptides

27 July 2018

1 reference

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Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients.

21 January 2018

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Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study

21 January 2018

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

21 January 2018

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21 January 2018

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Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes

21 January 2018

1 reference

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Single amino acid residue determinants of non-peptide antagonist binding to the corticotropin-releasing factor1 (CRF1) receptor.

21 January 2018

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Imidazoline NNC77-0074 stimulates insulin secretion and inhibits glucagon release by control of Ca(2+)-dependent exocytosis in pancreatic alpha- and beta-cells

21 January 2018

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Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors

21 January 2018

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Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605701104

Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605701104

Both Subcutaneously and Intravenously Administered Glucagon-Like Peptide I Are Rapidly Degraded From the NH2-Terminus in Type II Diabetic Patients and in Healthy Subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605701104

Discovery of a Small Molecule Insulin Mimetic with Antidiabetic Activity in Mice

21 January 2018

1 reference

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The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate recepto

21 January 2018

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12 December 2020

Stimulation of insulin release by repaglinide and glibenclamide involves both common and distinct processes

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12 December 2020

Alterations in pulsatile insulin secretion in the Zucker diabetic fatty rat

1 reference

12 December 2020

U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. U.K. Prospective Diabetes Study Group

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0605701104

1 reference

9 August 2017

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9 August 2017

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