Inhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury (Q35612752)

9 August 2017

Inhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury (English)

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9 August 2017

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Jeffery D Molkentin

7

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Steven R Houser

6

object named as

Steven R Houser

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9 August 2017

4

Robert N Correll

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9 August 2017

Dennis Ladage

1

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9 August 2017

Lisa Tilemann

2

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9 August 2017

Kiyotake Ishikawa

3

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9 August 2017

Yoshiaki Kawase

5

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9 August 2017

Roger J Hajjar

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9 August 2017

13 October 2011

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109

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1396-1400

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9 August 2017

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Protein kinase Cα as a heart failure therapeutic target

9 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237728

PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237728

Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237728

Structural basis of protein kinase C isoform function

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237728

Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237728

PKC isozymes in chronic cardiac disease: possible therapeutic targets?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237728

Effect of ruboxistaurin in patients with diabetic macular edema: thirty-month results of the randomized PKC-DMES clinical trial

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237728

Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237728

PKC-alpha regulates cardiac contractility and propensity toward heart failure

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237728

Protein Kinase Cα Negatively Regulates Systolic and Diastolic Function in Pathological Hypertrophy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237728

Ischemic preconditioning induces selective translocation of protein kinase C isoforms epsilon and eta in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237728

PKCbeta modulates ischemia-reperfusion injury in the heart

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237728

Effects of chronic renal failure on the pharmacokinetics of ruboxistaurin and its active metabolite 338522.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237728

Alterations in protein kinase C isoenzyme expression and autophosphorylation during the progression of pressure overload-induced left ventricular hypertrophy

25 September 2018

1 reference

12 December 2020

Enhanced PKC beta II translocation and PKC beta II-RACK1 interactions in PKC epsilon-induced heart failure: a role for RACK1

1 reference

12 December 2020

Increased protein kinase C and isozyme redistribution in pressure-overload cardiac hypertrophy in the rat

1 reference

12 December 2020

Effect of angiotensin-converting enzyme inhibition on protein kinase C and SR proteins in heart failure

1 reference

12 December 2020

Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart

1 reference

12 December 2020

Inhibition of protein kinase C reduces left ventricular fibrosis and dysfunction following myocardial infarction

1 reference

12 December 2020

Protein kinase C in the human heart: differential regulation of the isoforms in aortic stenosis or dilated cardiomyopathy

1 reference

12 December 2020

Inhibition of protein kinase C-beta by ruboxistaurin preserves cardiac function and reduces extracellular matrix production in diabetic cardiomyopathy

1 reference

12 December 2020

Increased expression of protein kinase C isoforms in heart failure due to myocardial infarction

1 reference

12 December 2020

PKC translocation without changes in Galphaq and PLC-beta protein abundance in cardiac hypertrophy and failure

1 reference

12 December 2020

Calcineurin promotes protein kinase C and c-Jun NH2-terminal kinase activation in the heart. Cross-talk between cardiac hypertrophic signaling pathways

1 reference

12 December 2020

10.1161/CIRCRESAHA.111.255687

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DOI

1 reference

9 August 2017

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9 August 2017

1 reference