Regulation of the c-Abl and Bcr-Abl tyrosine kinases (Q35621355)

9 August 2017

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title

Regulation of the c-Abl and Bcr-Abl tyrosine kinases (English)

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9 August 2017

2

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9 August 2017

Oliver Hantschel

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publication date

1 January 2004

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Nature Reviews Molecular Cell Biology

9 August 2017

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9 August 2017

5

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9 August 2017

1

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9 August 2017

33-44

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https://scigraph.springernature.com/pub.10.1038/nrm1280

9 August 2017

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cites work

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The Abl family kinases: mechanisms of regulation and signaling

31 March 2020

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Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases

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Abl: mechanisms of regulation and activation.

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Bcr-Abl variants: biological and clinical aspects

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Chronic myelogenous leukemia

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Cycling, stressed-out and nervous: cellular functions of c-Abl

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Cellular RNA Homologous to the Abelson Murine Leukemia Virus Transforming Gene: Expression and Relationship to the Viral Sequence

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Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome

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Chronic Myeloid Leukemia — Advances in Biology and New Approaches to Treatment

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A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins

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The NH(2)-terminal coiled-coil domain and tyrosine 177 play important roles in induction of a myeloproliferative disease in mice by Bcr-Abl

31 March 2020

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Activation of c-Abl kinase activity and transformation by a chemical inducer of dimerization

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Structure-function relationships in Src family and related protein tyrosine kinases

31 March 2020

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The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species

31 March 2020

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c-Abl kinase regulates the protein binding activity of c-Crk

31 March 2020

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Activation of the Abl tyrosine kinase in vivo by Src homology 3 domains from the Src homology 2/Src homology 3 adaptor Nck.

31 March 2020

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Interaction between ATM protein and c-Abl in response to DNA damage

31 March 2020

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A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

31 March 2020

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Identification of a binding site in c-Ab1 tyrosine kinase for the C-terminal repeated domain of RNA polymerase II.

31 March 2020

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The DNA-binding domain of human c-Abl tyrosine kinase promotes the interaction of a HMG chromosomal protein with DNA.

31 March 2020

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The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity

31 March 2020

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The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization

31 March 2020

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Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase

31 March 2020

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Oncogenic activation of c-ABL by mutation within its last exon.

31 March 2020

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31 March 2020

Autoinhibition of c-Abl

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Structural basis for the autoinhibition of c-Abl tyrosine kinase

31 March 2020

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Variation on an Src-like theme

31 March 2020

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Cancer: Escape from inhibition

31 March 2020

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Three-dimensional structure of the tyrosine kinase c-Src

31 March 2020

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Crystal structure of the Src family tyrosine kinase Hck

31 March 2020

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The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions

31 March 2020

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An intramolecular SH3-domain interaction regulates c-Abl activity

31 March 2020

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Dynamic coupling between the SH2 and SH3 domains of c-Src and Hck underlies their inactivation by C-terminal tyrosine phosphorylation

31 March 2020

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A myristoyl/phosphotyrosine switch regulates c-Abl

31 March 2020

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A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK.

31 March 2020

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Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity

31 March 2020

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Integrins regulate the association and phosphorylation of paxillin by c-Abl

31 March 2020

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Regulation of Cbl phosphorylation by the Abl tyrosine kinase and the Nck SH2/SH3 adaptor

31 March 2020

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Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK

31 March 2020

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Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth

31 March 2020

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Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

31 March 2020

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The conformational plasticity of protein kinases

31 March 2020

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Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

31 March 2020

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Deletion of an N-terminal regulatory domain of the c-abl tyrosine kinase activates its oncogenic potential

31 March 2020

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Nonmyristoylated Abl proteins transform a factor-dependent hematopoietic cell line

31 March 2020

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c-Abl has high intrinsic tyrosine kinase activity that is stimulated by mutation of the Src homology 3 domain and by autophosphorylation at two distinct regulatory tyrosines

31 March 2020

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Phosphorylation and structure-based functional studies reveal a positive and a negative role for the activation loop of the c-Abl tyrosine kinase.

31 March 2020

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c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

31 March 2020

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c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis

31 March 2020

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Two distinct phosphorylation pathways have additive effects on Abl family kinase activation

31 March 2020

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Phosphotyrosine mapping in Bcr/Abl oncoprotein using phosphotyrosine-specific immonium ion scanning

31 March 2020

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Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry

31 March 2020

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Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

31 March 2020

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Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15

31 March 2020

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Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop

31 March 2020

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Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL.

31 March 2020

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An activating mutation in the ATP binding site of the ABL kinase domain.

31 March 2020

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Mutational analysis of the regulatory function of the c-Abl Src homology 3 domain

31 March 2020

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Structure and function of the SH3 domain

31 March 2020

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How often does the myristoylated N‐terminal latch of c‐Abl come off?

31 March 2020

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Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm

31 March 2020

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Autoinhibition of Bcr-Abl through its SH3 domain

31 March 2020

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A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1

31 March 2020

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c-Abl regulation: a tail of two lipids

31 March 2020

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Inhibition of c-Abl tyrosine kinase activity by filamentous actin

31 March 2020

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Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension

31 March 2020

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The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity

31 March 2020

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Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression

31 March 2020

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Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

31 March 2020

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Functional interaction between DNA-PK and c-Abl in response to DNA damage

31 March 2020

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Structure of N-myristoyltransferase with bound myristoylCoA and peptide substrate analogs

31 March 2020

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The biology and enzymology of protein N-myristoylation

31 March 2020

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Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins

31 March 2020

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Myristylation and palmitylation of Src family members: the fats of the matter

31 March 2020

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Caspase structure, proteolytic substrates, and function during apoptotic cell death

31 March 2020

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The protein kinase complement of the human genome

31 March 2020

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Domain movements in protein kinases

31 March 2020

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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

31 March 2020

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Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

31 March 2020

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PDGFRA activating mutations in gastrointestinal stromal tumors.

31 March 2020

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Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy

31 March 2020

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SH2 domains, interaction modules and cellular wiring

31 March 2020

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Phosphoinositide recognition domains

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1280

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9 August 2017

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PubMed ID

14708008