Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases. (Q35625978)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22039581%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases (English)

1 reference

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15 January 2020

author name string

Shao H Yang

1

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15 January 2020

Sandy Y Chang

2

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15 January 2020

Yiping Tu

3

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15 January 2020

Gregory W Lawson

4

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15 January 2020

Martin O Bergo

5

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15 January 2020

publication date

28 October 2011

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Journal of Lipid Research

15 January 2020

published in

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15 January 2020

volume

53

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15 January 2020

issue

1

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15 January 2020

page(s)

77-86

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Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice

15 January 2020

cites work

1 reference

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Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer

27 July 2018

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Cre activity in fetal albCre mouse hepatocytes: Utility for developmental studies

27 July 2018

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In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I

27 July 2018

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Caution! Analyze transcripts from conditional knockout alleles

27 July 2018

1 reference

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Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated.

27 July 2018

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Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.

27 July 2018

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GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer

27 July 2018

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Prelamin A farnesylation and progeroid syndromes

27 July 2018

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A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation.

27 July 2018

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Prelamin A and lamin A appear to be dispensable in the nuclear lamina

27 July 2018

1 reference

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A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria.

27 July 2018

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Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes

27 July 2018

1 reference

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Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.

27 July 2018

1 reference

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Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development

27 July 2018

1 reference

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Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice

27 July 2018

1 reference

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Farnesyltransferase Inhibitors and Their Role in the Treatment of Multiple Myeloma

27 July 2018

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A simple method for the isolation and purification of total lipides from animal tissues

27 July 2018

1 reference

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

27 July 2018

1 reference

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Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243483

Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies

27 July 2018

1 reference

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Rho GTPases and the actin cytoskeleton

27 July 2018

1 reference

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Inhibition of Ras prenylation: a signaling target for novel anti-cancer drug design

27 July 2018

1 reference

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Protein prenylation: molecular mechanisms and functional consequences

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243483

Protein prenyltransferases

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243483

Inhibitors of Ras farnesyltransferases

27 July 2018

1 reference

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Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

27 July 2018

1 reference

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p21ras is modified by a farnesyl isoprenoid

27 July 2018

1 reference

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All ras proteins are polyisoprenylated but only some are palmitoylated

27 July 2018

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Differential inhibitory effects of lovastatin on protein isoprenylation and sterol synthesis

27 July 2018

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Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein

27 July 2018

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Chapter 4 Preparation of Isolated Rat Liver Cells

27 July 2018

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Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

27 July 2018

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RAM2, an essential gene of yeast, and RAM1 encode the two polypeptide components of the farnesyltransferase that prenylates a-factor and Ras proteins

21 January 2018

1 reference

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The RAM1 gene encoding a protein-farnesyltransferase beta-subunit homologue is essential in Cryptococcus neoformans

21 January 2018

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A phase II study of Lonafarnib (SCH66336) in patients with chemorefractory, advanced squamous cell carcinoma of the head and neck.

21 January 2018

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Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes.

21 January 2018

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Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy.

21 January 2018

1 reference

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Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression

21 January 2018

1 reference

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Mouse liver cell culture. I. Hepatocyte isolation

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22039581

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Chapter 24 Isolation and Characterization of Intermediate Filaments

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22039581

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22039581

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1194/JLR.M021220

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22039581%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

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15 January 2020

PubMed publication ID

22039581

1 reference