Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition (Q35629787)

9 August 2017

title

Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition (English)

1 reference

9 August 2017

1 reference

Brian M Weist

1

1 reference

9 August 2017

Nadia Kurd

2

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9 August 2017

Jeremy Boussier

3

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9 August 2017

Shiao Wei Chan

4

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9 August 2017

Ellen A Robey

5

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9 August 2017

language of work or name

English

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publication date

4 May 2015

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9 August 2017

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9 August 2017

volume

16

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9 August 2017

issue

6

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9 August 2017

page(s)

635-641

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Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia

9 August 2017

cites work

1 reference

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Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus

27 July 2018

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Once a Treg, always a Treg?

27 July 2018

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Distinct temporal patterns of T cell receptor signaling during positive versus negative selection in situ

27 July 2018

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MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells

27 July 2018

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Opposing chemokine gradients control human thymocyte migration in situ

27 July 2018

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Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway

27 July 2018

1 reference

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Therapeutic opportunities for manipulating T(Reg) cells in autoimmunity and cancer

27 July 2018

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Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells

27 July 2018

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A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self.

27 July 2018

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Two-photon imaging of the immune system

27 July 2018

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T-cell receptor affinity in thymic development.

27 July 2018

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Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance

27 July 2018

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Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments.

27 July 2018

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Differential contribution of chemotaxis and substrate restriction to segregation of immature and mature thymocytes

27 July 2018

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Thymus-blood protein interactions are highly effective in negative selection and regulatory T cell induction

27 July 2018

1 reference

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TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes

27 July 2018

1 reference

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The thymic medulla: a unique microenvironment for intercellular self-antigen transfer

27 July 2018

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Intraclonal competition limits the fate determination of regulatory T cells in the thymus

27 July 2018

1 reference

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In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

27 July 2018

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Dendritic cells in the thymus contribute to T-regulatory cell induction

27 July 2018

1 reference

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Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire.

27 July 2018

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A two-step process for thymic regulatory T cell development.

27 July 2018

1 reference

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Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

27 July 2018

1 reference

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A function for interleukin 2 in Foxp3-expressing regulatory T cells

27 July 2018

1 reference

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Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439282

CD25+ CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439282

Interleukin-2 is essential for CD4+CD25+ regulatory T cell function

27 July 2018

1 reference

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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

27 July 2018

1 reference

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Inducible IL-2 production by dendritic cells revealed by global gene expression analysis.

27 July 2018

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Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance

27 July 2018

1 reference

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Regulatory CD4(+) T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis

27 July 2018

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Constitutive class I-restricted exogenous presentation of self antigens in vivo

27 July 2018

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Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation

27 July 2018

1 reference

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Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439282

Long term culture of tumour-specific cytotoxic T cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439282

Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439282

Dendritic cells control CD4+CD25+ Treg cell suppressor function in vitro through juxtacrine delivery of IL-2.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439282

Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439282

The role of interleukin-2 during homeostasis and activation of the immune system

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439282

Cutting Edge: Hematopoietic-Derived APCs Select Regulatory T Cells in Thymus

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439282

Human T regulatory cell therapy: take a billion or so and call me in the morning

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439282

IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439282

CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439282

Selective stimulation of T cell subsets with antibody-cytokine immune complexes.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439282

The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elements

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439282

CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25939026

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25939026

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25939026

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NI.3171

1 reference

Dimensions Publication ID

9 August 2017

0 references

1 reference

9 August 2017

1 reference