The Cain and Abl of Epithelial-Mesenchymal Transition and Transforming Growth Factor-β in Mammary Epithelial Cells (Q35633302)

9 August 2017

title

The Cain and Abl of epithelial-mesenchymal transition and transforming growth factor-β in mammary epithelial cells (English)

1 reference

https://api.crossref.org/works/10.1159/000320163

9 August 2017

The Cain and Abl of Epithelial-Mesenchymal Transition and Transforming Growth Factor-β in Mammary Epithelial Cells (English)

1 reference

20 August 2024

author name string

Tressa M. Allington

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21051857

20 August 2024

William P. Schiemann

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21051857

20 August 2024

language of work or name

1 reference

3 November 2010

1 reference

full work available at URL

9 August 2017

https://www.karger.com/Article/Pdf/320163

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21051857

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21051857/?tool=EBI

20 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21051857

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21051857/pdf/?tool=EBI

20 August 2024

file format

Portable Document Format

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21051857

https://europepmc.org/articles/PMC3245834

20 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21051857

https://europepmc.org/articles/PMC3245834?pdf=render

20 August 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21051857

https://doi.org/10.1159/000320163

20 August 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21051857

https://www.karger.com/Article/Pdf/320163

20 August 2024

1 reference

https://api.crossref.org/works/10.1159/000320163

20 August 2024

1 reference

9 August 2017

volume

193

1 reference

9 August 2017

issue

1-2

1 reference

9 August 2017

page(s)

98-113

1 reference

Smaddening Complexity: The Role of Smad3 in Epithelial-Myofibroblast Transition

9 August 2017

cites work

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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A phase II study of imatinib mesylate and capecitabine in metastatic breast cancer: Southwest Oncology Group Study 0338

27 July 2018

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Three-dimensional context regulation of metastasis

27 July 2018

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Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-beta through a PGE2-dependent mechanisms

27 July 2018

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Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGF-beta in mammary epithelial cells via a MMP-dependent mechanism

27 July 2018

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27 July 2018

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Imatinib mesylate for the treatment of chronic myeloid leukemia

27 July 2018

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Imatinib mesylate (Gleevec) in advanced breast cancer-expressing C-Kit or PDGFR-beta: clinical activity and biological correlations

27 July 2018

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The epithelial-mesenchymal transition generates cells with properties of stem cells

27 July 2018

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Activated c-Abl tyrosine kinase in malignant solid tumors

27 July 2018

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Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression

27 July 2018

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Abl tyrosine kinases modulate cadherin-dependent adhesion upstream and downstream of Rho family GTPases

27 July 2018

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Grb2 binding to Tyr284 in TbetaR-II is essential for mammary tumor growth and metastasis stimulated by TGF-beta

27 July 2018

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Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis

27 July 2018

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Abl tyrosine kinases regulate cell-cell adhesion through Rho GTPases

27 July 2018

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Transforming growth factor-beta can suppress tumorigenesis through effects on the putative cancer stem or early progenitor cell and committed progeny in a breast cancer xenograft model

27 July 2018

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Aggressive breast cancer cells are dependent on activated Abl kinases for proliferation, anchorage-independent growth and survival

27 July 2018

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Treatment for chronic myelogenous leukemia: the long road to imatinib

27 July 2018

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Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway

27 July 2018

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Oncogenic activation of c-Abl in non-small cell lung cancer cells lacking FUS1 expression: inhibition of c-Abl by the tumor suppressor gene product Fus1

27 July 2018

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27 July 2018

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TGF-beta signaling in breast cancer

27 July 2018

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Transforming growth factor beta activation of c-Abl is independent of receptor internalization and regulated by phosphatidylinositol 3-kinase and PAK2 in mesenchymal cultures

27 July 2018

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Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer

27 July 2018

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Activation of Abl tyrosine kinases promotes invasion of aggressive breast cancer cells

27 July 2018

1 reference

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The use of cystatin C to inhibit epithelial-mesenchymal transition and morphological transformation stimulated by transforming growth factor-beta

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245834

Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks

27 July 2018

1 reference

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Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

27 July 2018

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TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition

27 July 2018

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Imatinib mesylate blocks a non-Smad TGF-beta pathway and reduces renal fibrogenesis in vivo

27 July 2018

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Stromal fibroblasts in cancer initiation and progression

27 July 2018

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Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro

27 July 2018

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Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis

27 July 2018

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c-Abl phosphorylates Dok1 to promote filopodia during cell spreading

27 July 2018

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Tumor necrosis factor alpha-induced apoptosis requires p73 and c-ABL activation downstream of RB degradation

27 July 2018

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Role of transforming growth factor beta in breast carcinogenesis

27 July 2018

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Death by Abl: a matter of location

27 July 2018

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TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia

27 July 2018

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Epithelial-mesenchymal transitions in development and pathologies

27 July 2018

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Repeated observation of breast tumor subtypes in independent gene expression data sets

27 July 2018

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27 July 2018

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Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension

27 July 2018

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27 July 2018

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Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

27 July 2018

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27 July 2018

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Inhibition of c-Abl tyrosine kinase activity by filamentous actin

27 July 2018

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Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes

27 July 2018

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Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase.

27 July 2018

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Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.

27 July 2018

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27 July 2018

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c-Abl: activation and nuclear targets

27 July 2018

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27 July 2018

The Hallmarks of Cancer

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c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

27 July 2018

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p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

27 July 2018

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Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis

27 July 2018

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Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase

27 July 2018

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Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

27 July 2018

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Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic-nuclear transport

27 July 2018

1 reference

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TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells

27 July 2018

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Nuclear tyrosine kinases: from Abl to WEE1.

27 July 2018

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The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products

27 July 2018

1 reference

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Activated Abl kinase inhibits oncogenic transforming growth factor-beta signaling and tumorigenesis in mammary tumors

27 July 2018

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The basics of epithelial-mesenchymal transition

25 September 2018

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Role of c-Abl kinase in DNA mismatch repair-dependent G2 cell cycle checkpoint arrest responses.

25 September 2018

1 reference

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DNA mismatch repair-dependent activation of c-Abl/p73alpha/GADD45alpha-mediated apoptosis.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245834

A phase II trial of imatinib mesylate in patients with metastatic pancreatic cancer

25 September 2018

1 reference

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Epithelial--mesenchymal and mesenchymal--epithelial transitions in carcinoma progression.

25 September 2018

1 reference

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A phase I trial of docetaxel/estramustine/imatinib in patients with hormone-refractory prostate cancer

25 September 2018

1 reference

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The tyrosine kinase Abl is required for Src-transforming activity in mouse fibroblasts and human breast cancer cells

25 September 2018

1 reference

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Regulation of cellular transformation by oncogenic and normal Abl kinases

25 September 2018

1 reference

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Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer.

25 September 2018

1 reference

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The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245834

Beta3 integrin and Src facilitate transforming growth factor-beta mediated induction of epithelial-mesenchymal transition in mammary epithelial cells

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245834

A phase II trial of imatinib mesylate in patients with biochemical relapse of prostate cancer after definitive local therapy

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245834

The tyrosine kinase inhibitor imatinib fails to inhibit pancreatic cancer progression

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245834

A phase II trial of imatinib mesylate monotherapy in patients with metastatic breast cancer.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245834

NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245834

Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245834

Cytoplasmic c-Abl provides a molecular 'Rheostat' controlling carcinoma cell survival and invasion

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245834

Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245834

Activated c-Abl is degraded by the ubiquitin-dependent proteasome pathway

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245834

Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245834

Role for c-Abl and p73 in the radiation response of male germ cells

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245834

Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile response to Hepatocyte Growth Factor.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245834

The mouse c-abl locus: molecular cloning and characterization

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245834

Circumventing Resistance to Kinase-Inhibitor Therapy

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245834

Eph tumour suppression: the dark side of Gleevec

15 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21051857

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasion

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21051857

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Targeted TGF-beta chemotherapies: friend or foe in treating human malignancies?

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21051857

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1159/000320163

1 reference

9 August 2017

1 reference

9 August 2017

1 reference