Cilia-like structures and polycystin-1 in osteoblasts/osteocytes and associated abnormalities in skeletogenesis and Runx2 expression. (Q35634081)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16905538%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

title

Cilia-like structures and polycystin-1 in osteoblasts/osteocytes and associated abnormalities in skeletogenesis and Runx2 expression (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16905538%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

0 references

11

1 reference

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28 December 2019

author name string

Zhousheng Xiao

1

1 reference

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28 December 2019

Shiqin Zhang

2

1 reference

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28 December 2019

Josh Mahlios

3

1 reference

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28 December 2019

Gan Zhou

4

1 reference

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28 December 2019

Brenda S Magenheimer

5

1 reference

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28 December 2019

Dayong Guo

6

1 reference

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28 December 2019

Sarah L Dallas

7

1 reference

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28 December 2019

Robin Maser

8

1 reference

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28 December 2019

James P Calvet

9

1 reference

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28 December 2019

Lynda Bonewald

10

1 reference

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28 December 2019

language of work or name

English

0 references

publication date

11 August 2006

1 reference

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Journal of Biological Chemistry

28 December 2019

published in

1 reference

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28 December 2019

volume

281

1 reference

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28 December 2019

issue

41

1 reference

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28 December 2019

page(s)

30884-30895

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16905538%20AND%20SRC:MED&resulttype=core&format=json

Runx2 is a target of mechanical unloading to alter osteoblastic activity and bone formation in vivo

28 December 2019

cites work

1 reference

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Molecular pathways mediating mechanical signaling in bone

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The P2X7 nucleotide receptor mediates skeletal mechanotransduction

27 July 2018

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PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts

27 July 2018

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Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression

27 July 2018

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Selective Runx2-II deficiency leads to low-turnover osteopenia in adult mice

27 July 2018

1 reference

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Subcellular localization and trafficking of polycystins

27 July 2018

1 reference

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C-fos expression of osteoblast-like MC3T3-E1 cells induced either by cooling or by fluid flow

27 July 2018

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Extracellular nucleotides activate Runx2 in the osteoblast-like HOBIT cell line: a possible molecular link between mechanical stress and osteoblasts' response

27 July 2018

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Molecular regulation of mechanotransduction

27 July 2018

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Mechanotransduction and strain amplification in osteocyte cell processes

27 July 2018

1 reference

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Polycystin-1 activates the calcineurin/NFAT (nuclear factor of activated T-cells) signaling pathway

27 July 2018

1 reference

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ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome

27 July 2018

1 reference

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Aberrant polycystin-1 expression results in modification of activator protein-1 activity, whereas Wnt signaling remains unaffected

27 July 2018

1 reference

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Polycystic kidney disease: the cilium as a common pathway in cystogenesis

27 July 2018

1 reference

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Murine models of polycystic kidney disease: molecular and therapeutic insights

27 July 2018

1 reference

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Transmembrane Domain Analysis of Polycystin-1, the Product of the Polycystic Kidney Disease-1 (PKD1) Gene: Evidence for 11 Membrane-Spanning Domains

27 July 2018

1 reference

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Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease

27 July 2018

1 reference

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Autosomal dominant polycystic kidney disease: molecular genetics and pathophysiology.

27 July 2018

1 reference

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IRES-dependent translational control of Cbfa1/Runx2 expression.

27 July 2018

1 reference

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Regulation of the osteoblast-specific transcription factor, Runx2: responsiveness to multiple signal transduction pathways

27 July 2018

1 reference

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Simulated microgravity suppresses osteoblast phenotype, Runx2 levels and AP-1 transactivation

27 July 2018

1 reference

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Removal of the MDCK cell primary cilium abolishes flow sensing

27 July 2018

1 reference

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The vertebrate primary cilium is a sensory organelle

27 July 2018

1 reference

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Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

27 July 2018

1 reference

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A model for mechanotransduction in bone cells: the load-bearing mechanosomes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

Polaris, a protein disrupted in orpk mutant mice, is required for assembly of renal cilium

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis

27 July 2018

1 reference

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Superoxide mediates shock wave induction of ERK-dependent osteogenic transcription factor (CBFA1) and mesenchymal cell differentiation toward osteoprogenitors

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

Effects of microgravity on bone and calcium homeostasis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

Developmental regulation of osteocalcin expression in MC3T3-E1 osteoblasts: minimal role of the proximal E-box cis-acting promoter elements

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

Functional strain in bone tissue as an objective, and controlling stimulus for adaptive bone remodelling

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

JNK/ERK-AP-1/Runx2 induction "paves the way" to cartilage load-ignited chondroblastic differentiation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

Polycystins: polymodal receptor/ion-channel cellular sensors

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

Signal transduction and mechanical stress

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

Polycystins, calcium signaling, and human diseases.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

Micro-CT evaluation of tooth, calvaria and mechanical stress-induced tooth movement in adult Runx2/Cbfa1 heterozygous knock-out mice.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

Selective deficiency of the "bone-related" Runx2-II unexpectedly preserves osteoblast-mediated skeletogenesis.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

Ultrastructural, tomographic and confocal imaging of the chondrocyte primary cilium in situ

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

Accurate and statistically verified quantification of relative mRNA abundances using SYBR Green I and real-time RT-PCR.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

Primary cilium—is it an osteocyte's strain‐sensing flowmeter?

25 September 2018

1 reference

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The bone-specific transcriptional regulator Cbfa1 is a target of mechanical signals in osteoblastic cells.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

Distinct and common developmental expression patterns of the murine Pkd2 and Pkd1 genes.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

Murine Pkd1 is a developmentally regulated gene from morula to adulthood: role in tissue condensation and patterning

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797154

Loss of Polycystin-1 in Human Cyst-Lining Epithelia Leads to Ciliary Dysfunction

25 September 2018

1 reference

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Rickets in cation-sensing receptor-deficient mice: an unexpected skeletal phenotype

7 December 2018

1 reference

12 December 2020

Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects

1 reference

12 December 2020

Polycystic kidney disease

1 reference

12 December 2020

Bone cell cilia: vestigial or functional organelles?

1 reference

12 December 2020

Ultrastructural characterization and immunolocalization of osteopontin in rat calvarial osteoblast primary cultures

1 reference

12 December 2020

Molecular basis of autosomal dominant polycystic kidney disease

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M604772200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16905538%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16905538%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

PubMed publication ID

16905538

1 reference