Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage (Q35639764)

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scientific article published on 3 November 2011

Language	Label	Description	Also known as
English	Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage	scientific article published on 3 November 2011

Statements

scholarly article

1 reference

Europe PubMed Central

9 August 2017

Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage (English)

1 reference

Europe PubMed Central

9 August 2017

0 references

apoptotic process

1 reference

based on heuristic

inferred from title

5

object named as

Sarah Spiegel

1 reference

Europe PubMed Central

9 August 2017

author name string

Sandrine Lépine

1

1 reference

Europe PubMed Central

9 August 2017

Jeremy C Allegood

2

1 reference

Europe PubMed Central

9 August 2017

Yvette Edmonds

3

1 reference

Europe PubMed Central

9 August 2017

Sheldon Milstien

4

1 reference

Europe PubMed Central

9 August 2017

language of work or name

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publication date

3 November 2011

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Europe PubMed Central

9 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

9 August 2017

286

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Europe PubMed Central

9 August 2017

52

1 reference

Europe PubMed Central

9 August 2017

44380-44390

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Europe PubMed Central

9 August 2017

The outs and the ins of sphingosine-1-phosphate in immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247960

12 July 2018

The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247960

12 July 2018

Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism

1 reference

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12 July 2018

Autophagy and the integrated stress response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247960

12 July 2018

Protein quality control in the cytosol and the endoplasmic reticulum: brothers in arms.

1 reference

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12 July 2018

Exogenous cell-permeable C6 ceramide sensitizes multiple cancer cell lines to Doxorubicin-induced apoptosis by promoting AMPK activation and mTORC1 inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247960

12 July 2018

Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy

1 reference

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Sphingosine 1-phosphate and cancer

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Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiation-associated gene 7/interleukin-24

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Control of basal autophagy by calpain1 mediated cleavage of ATG5

1 reference

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Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

1 reference

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Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response.

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12 July 2018

Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways

1 reference

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Cytoplasmic functions of the tumour suppressor p53.

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12 July 2018

Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway

1 reference

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12 July 2018

The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells

1 reference

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12 July 2018

PARP-1 is involved in autophagy induced by DNA damage.

1 reference

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12 July 2018

Ceramide starves cells to death by downregulating nutrient transporter proteins

1 reference

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12 July 2018

DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death.

1 reference

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12 July 2018

Regulation of autophagy by cytoplasmic p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247960

12 July 2018

Silencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells

1 reference

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12 July 2018

A role for ceramide in driving cancer cell resistance to doxorubicin.

1 reference

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12 July 2018

Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247960

12 July 2018

Autocrine and paracrine roles of sphingosine-1-phosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247960

12 July 2018

Human X-box binding protein-1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines.

1 reference

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12 July 2018

Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247960

12 July 2018

Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247960

12 July 2018

Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247960

12 July 2018

Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247960

12 July 2018

Autophagy is activated for cell survival after endoplasmic reticulum stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247960

12 July 2018

Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247960

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Doxorubicin prevents endoplasmic reticulum stress-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247960

12 July 2018

Biologically active sphingolipids in cancer pathogenesis and treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247960

12 July 2018

Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247960

12 July 2018

Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247960

12 July 2018

Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability

1 reference

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12 July 2018

The therapeutic potential of modulating the ceramide/sphingomyelin pathway

1 reference

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12 July 2018

Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide.

1 reference

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Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis

1 reference

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Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis

1 reference

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Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1 reference

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12 July 2018

Intracellular calcium release mediated by sphingosine derivatives generated in cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247960

12 July 2018

Doxorubicin-induced apoptosis in germinal vesicle (GV) oocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247960

25 September 2018

Doxycycline suppresses doxorubicin-induced oxidative stress and cellular apoptosis in mouse hearts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247960

25 September 2018

Protection of C. elegans from anoxia by HYL-2 ceramide synthase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247960

25 September 2018

Life and death partners: apoptosis, autophagy and the cross-talk between them

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247960

25 September 2018

A CERTain role for ceramide in taxane-induced cell death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247960

25 September 2018

Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247960

25 September 2018

Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells.

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25 September 2018

Identifiers

10.1074/JBC.M111.257519

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Europe PubMed Central

9 August 2017

release_zazdu4nwsfh6fbnnwz77kzd6lm

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https://api.fatcat.wiki/v0/release/zazdu4nwsfh6fbnnwz77kzd6lm

24 November 2022

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mapped directly with Wikidata item

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Europe PubMed Central

9 August 2017

1 reference

Europe PubMed Central

9 August 2017

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