Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers. (Q35640316)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21896958%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21896958%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

2

1 reference

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Christine A Iacobuzio-Donahue

12 February 2020

9

object named as

Christine Iacobuzio-Donahue

1 reference

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12 February 2020

12

Angelo M De Marzo

1 reference

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Srinivasan Yegnasubramanian

12 February 2020

13

object named as

Srinivasan Yegnasubramanian

1 reference

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12 February 2020

11

George J Netto

1 reference

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12 February 2020

4

David M Esopi

1 reference

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12 February 2020

7

Antoun Toubaji

1 reference

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12 February 2020

3

Alan K Meeker

1 reference

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12 February 2020

6

Laxmi G Pellakuru

1 reference

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12 February 2020

8

Pedram Argani

1 reference

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12 February 2020

author name string

Michael C Haffner

1

1 reference

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12 February 2020

Jonathan Gerber

5

1 reference

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12 February 2020

William G Nelson

10

1 reference

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12 February 2020

language of work or name

English

0 references

publication date

1 August 2011

1 reference

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12 February 2020

1 reference

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12 February 2020

volume

2

1 reference

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12 February 2020

page(s)

627-637

1 reference

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12 February 2020

issue

8

1 reference

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Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

12 February 2020

cites work

1 reference

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Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development.

12 July 2018

1 reference

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Recognition of 5-hydroxymethylcytosine by the Uhrf1 SRA domain

12 July 2018

1 reference

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Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

12 July 2018

1 reference

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Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

12 July 2018

1 reference

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Identification of replication competent murine gammaretroviruses in commonly used prostate cancer cell lines

12 July 2018

1 reference

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5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells

12 July 2018

1 reference

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Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

12 July 2018

1 reference

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LINE-1 hypomethylation during primary colon cancer progression

12 July 2018

1 reference

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Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

12 July 2018

1 reference

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TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

12 July 2018

1 reference

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Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

12 July 2018

1 reference

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Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells.

12 July 2018

1 reference

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DNA methylation and demethylation in mammals

12 July 2018

1 reference

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Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells.

12 July 2018

1 reference

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Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

The genomic complexity of primary human prostate cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

Prostate cancer: New answers prompt new questions regarding cell of origin.

12 July 2018

1 reference

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Characterization of chronic myeloid leukemia stem cells.

12 July 2018

1 reference

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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

Diverse somatic mutation patterns and pathway alterations in human cancers

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

CD34 stem cell stories and lessons from the CD34 wars: the Landsteiner Lecture 2009.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

Stem cells in the human breast

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

Rethinking how DNA methylation patterns are maintained

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

Epigenetic alterations in human prostate cancers.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

DNA hypomethylation arises later in prostate cancer progression than CpG island hypermethylation and contributes to metastatic tumor heterogeneity.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

Stem cells, self-renewal, and differentiation in the intestinal epithelium

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

The colorful history of active DNA demethylation.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

Phenotypic and functional characterization of hematopoietic stem cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

12 July 2018

Epigenetics in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

Identification of stem cells in small intestine and colon by marker gene Lgr5

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

The genomic landscapes of human breast and colorectal cancers

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

Stability and flexibility of epigenetic gene regulation in mammalian development

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

The epigenomics of cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

The consensus coding sequences of human breast and colorectal cancers

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

DNA hypomethylation is prevalent even in low-grade breast cancers

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2).

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

The bases of the nucleic acids of some bacterial and animal viruses: the occurrence of 5-hydroxymethylcytosine

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

Response of glandular versus basal rat ventral prostatic epithelial cells to androgen withdrawal and replacement

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

Use of keratin 903 as an adjunct in the diagnosis of prostate carcinoma

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

Modification of brain deoxyribonucleic acid base content with maturation in normal and malnourished rats

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

5-Methylcytosine content in the vertebrate deoxyribonucleic acids: species specificity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248214

Genomic 5-hydroxymethylcytosine levels correlate with TET2 mutations and a distinct global gene expression pattern in secondary acute myeloid leukemia

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21896958

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.316

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21896958%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21896958%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference