Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51) (Q35642775)

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scientific article published on 26 May 2015

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English	Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51)	scientific article published on 26 May 2015

Statements

scholarly article

1 reference

Europe PubMed Central

9 August 2017

Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51) (English)

1 reference

Europe PubMed Central

9 August 2017

Acanthamoeba polyphaga

1 reference

based on heuristic

inferred from title

Acanthamoeba castellanii

object named as

Acanthamoeba castellanii

1 reference

based on heuristic

inferred from title

Andrew Warrilow

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26014948%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

author name string

David C Lamb

1

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12 June 2020

Nicola J Rolley

3

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12 June 2020

Josie E Parker

4

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12 June 2020

W David Nes

5

1 reference

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12 June 2020

Stephen N Smith

6

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12 June 2020

Diane E Kelly

7

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12 June 2020

Steven L Kelly

8

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12 June 2020

language of work or name

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publication date

26 May 2015

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9 August 2017

Antimicrobial Agents and Chemotherapy

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12 June 2020

59

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12 June 2020

8

1 reference

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12 June 2020

4707-4713

1 reference

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12 June 2020

The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme.

1 reference

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12 July 2018

SJL mice infected with Acanthamoeba castellanii develop central nervous system autoimmunity through the generation of cross-reactive T cells for myelin antigens

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Acanthamoeba keratitis: an emerging disease gathering importance worldwide?

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Prothioconazole and prothioconazole-desthio activities against Candida albicans sterol 14-α-demethylase

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Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens

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Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) from Leishmania infantum

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Structural basis for conservation in the CYP51 family

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Successful treatment of chronic stromal acanthamoeba keratitis with oral voriconazole monotherapy

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Expression and functional characterization of cytochrome P450 26A1, a retinoic acid hydroxylase

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Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth

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Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms

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Acanthamoeba: biology and increasing importance in human health

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In-vitro activity of miltefosine and voriconazole on clinical isolates of free-living amebas: Balamuthia mandrillaris, Acanthamoeba spp., and Naegleria fowleri

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Free-living amoebae as opportunistic and non-opportunistic pathogens of humans and animals

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THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES

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12 July 2018

Acanthamoebaspp. as Agents of Disease in Humans

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Acanthamoeba keratitis in England and Wales: incidence, outcome, and risk factors

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Characterization and catalytic properties of the sterol 14alpha-demethylase from Mycobacterium tuberculosis

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12 July 2018

Optimized expression and catalytic properties of a wheat obtusifoliol 14alpha-demethylase (CYP51) expressed in yeast. Complementation of erg11Delta yeast mutants by plant CYP51.

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12 July 2018

Acanthamoeba keratitis: multicentre survey in England 1992-6. National Acanthamoeba Keratitis Study Group

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Free-living, amphizoic and opportunistic amebas

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Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors

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Sterol biosynthesis de nova via cycloartenol by the soil amoeba Acanthamoeba polyphaga

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Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli

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27 Measurement of substrate and inhibitor binding to microsomal cytochrome P-450 by optical-difference spectroscopy

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Molecular diversity of sterol 14alpha-demethylase substrates in plants, fungi and humans

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Acanthamoeba keratitis with live isolates treated with cryosurgery and fluconazole

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Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists

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Successful Monitoring and Treatment of Intraocular Dissemination of Acanthamoeba

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Identifiers

10.1128/AAC.00476-15

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Europe PubMed Central

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release_32ybx47sznglxlwxh5ycw4sdma

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24 November 2022

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12 June 2020

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12 June 2020

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