Phenolic compounds prevent the oligomerization of α-synuclein and reduce synaptic toxicity (Q35643171)

9 August 2017

Phenolic compounds prevent the oligomerization of α-synuclein and reduce synaptic toxicity (English)

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9 August 2017

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Ryoichi Takahashi

1

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9 August 2017

Kenjiro Ono

2

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9 August 2017

Yusaku Takamura

3

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9 August 2017

Mineyuki Mizuguchi

4

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9 August 2017

Tokuhei Ikeda

5

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9 August 2017

Hisao Nishijo

6

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9 August 2017

Masahito Yamada

7

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9 August 2017

language of work or name

English

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publication date

27 May 2015

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Journal of Neurochemistry

9 August 2017

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9 August 2017

134

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9 August 2017

5

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9 August 2017

943-955

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Molecular basis for preventing α-synuclein aggregation by a molecular tweezer.

9 August 2017

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Bioavailability of curcumin: problems and promises

21 January 2018

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Prospective study of caffeine consumption and risk of Parkinson's disease in men and women.

21 January 2018

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EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity.

21 January 2018

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Rapid photochemical cross-linking--a new tool for studies of metastable, amyloidogenic protein assemblies

21 January 2018

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Flavonoids and breast cancer risk in Italy

21 January 2018

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Stages in the development of Parkinson's disease-related pathology

21 January 2018

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Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation

21 January 2018

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Genetic and environmental risk factors for Parkinson's disease in a Chinese population

21 January 2018

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Nutraceuticals and their preventive or potential therapeutic value in Parkinson's disease

21 January 2018

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NMRPipe: a multidimensional spectral processing system based on UNIX pipes

21 January 2018

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Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation.

21 January 2018

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EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

21 January 2018

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Chemistry for the analysis of protein-protein interactions: rapid and efficient cross-linking triggered by long wavelength light

21 January 2018

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Habitual intake of dietary flavonoids and risk of Parkinson disease

21 January 2018

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Amino acid type determination in the sequential assignment procedure of uniformly 13C/15N-enriched proteins.

21 January 2018

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Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125.

21 January 2018

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Role of C-terminal negative charges and tyrosine residues in fibril formation of α-synuclein.

21 January 2018

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Parkinson's disease: clinical features and diagnosis

21 January 2018

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Curcumin ameliorates the neurodegenerative pathology in A53T α-synuclein cell model of Parkinson's disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy

21 January 2018

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Dose escalation of a curcuminoid formulation

21 January 2018

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Extracellular α--synuclein-a novel and crucial factor in Lewy body diseases.

21 January 2018

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Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution

21 January 2018

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Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration

21 January 2018

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The N-terminus of α-synuclein is essential for both monomeric and oligomeric interactions with membranes

21 January 2018

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How epigallocatechin gallate can inhibit α-synuclein oligomer toxicity in vitro

21 January 2018

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Synaptic plasticity and memory: an evaluation of the hypothesis

21 January 2018

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α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases

21 January 2018

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Small molecule inhibitors of alpha-synuclein filament assembly

21 January 2018

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Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium

21 January 2018

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Antioxidant compounds have potent anti-fibrillogenic and fibril-destabilizing effects for alpha-synuclein fibrils in vitro

21 January 2018

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Low-n oligomers as therapeutic targets of Alzheimer's disease

21 January 2018

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Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease

21 January 2018

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Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity

21 January 2018

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Familial Parkinson disease mutations influence α-synuclein assembly

21 January 2018

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Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding

21 January 2018

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Effects of antiparkinsonian agents on β-amyloid and α-synuclein oligomer formation in vitro

21 January 2018

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Formation of toxic oligomeric alpha-synuclein species in living cells

21 January 2018

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Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies.

21 January 2018

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A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.

21 January 2018

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Characterization of alpha-synuclein interactions with selected aggregation-inhibiting small molecules

21 January 2018

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Effect of pseudorepeat rearrangement on alpha-synuclein misfolding, vesicle binding, and micelle binding

21 January 2018

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Consistent blind protein structure generation from NMR chemical shift data

21 January 2018

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De novo protein structure generation from incomplete chemical shift assignments.

21 January 2018

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Synthesis of alginate-curcumin nanocomposite and its protective role in transgenic Drosophila model of Parkinson's disease

21 January 2018

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Effect of curcumin on lifespan, activity pattern, oxidative stress, and apoptosis in the brains of transgenic Drosophila model of Parkinson's disease

21 January 2018

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alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

21 January 2018

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Effects of the neurotrophic agent T-817MA on oligomeric amyloid-β-induced deficits in long-term potentiation in the hippocampal CA1 subfield

21 January 2018

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Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.

21 January 2018

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Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases

21 January 2018

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Stabilization of partially folded conformation during alpha-synuclein oligomerization in both purified and cytosolic preparations

21 January 2018

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The first N-terminal amino acids of alpha-synuclein are essential for alpha-helical structure formation in vitro and membrane binding in yeast

21 January 2018

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Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.

21 January 2018

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NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

21 January 2018

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Neuroprotective molecular mechanisms of (-)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties

21 January 2018

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In vivo demonstration that alpha-synuclein oligomers are toxic

21 January 2018

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alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease

21 January 2018

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Characterization of conformational and dynamic properties of natively unfolded human and mouse alpha-synuclein ensembles by NMR: implication for aggregation.

21 January 2018

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Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

21 January 2018

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At low concentrations, 3,4-dihydroxyphenylacetic acid (DOPAC) binds non-covalently to alpha-synuclein and prevents its fibrillation

21 January 2018

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The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/JNC.13180

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9 August 2017

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