Niemann-pick C1 is essential for ebolavirus replication and pathogenesis in vivo. (Q35660156)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26015498%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

title

Niemann-pick C1 is essential for ebolavirus replication and pathogenesis in vivo (English)

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15 February 2020

2

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John M Dye

12

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10

Kartik Chandran

1 reference

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15 February 2020

author name string

Andrew S Herbert

1

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15 February 2020

Ana I Kuehne

3

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15 February 2020

Russell Bakken

4

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15 February 2020

Stephen Z Braigen

5

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15 February 2020

Kathryn E Gunn

6

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15 February 2020

Sean P Whelan

7

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15 February 2020

Thijn R Brummelkamp

8

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15 February 2020

Nancy A Twenhafel

9

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Steven U Walkley

11

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15 February 2020

publication date

26 May 2015

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15 February 2020

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15 February 2020

volume

6

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15 February 2020

issue

3

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15 February 2020

page(s)

e00565-15

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Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection

15 February 2020

cites work

1 reference

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Niemann-Pick C1 (NPC1)/NPC1-like1 chimeras define sequences critical for NPC1's function as a flovirus entry receptor

27 July 2018

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Chinese hamster ovary cell lines selected for resistance to ebolavirus glycoprotein mediated infection are defective for NPC1 expression.

27 July 2018

1 reference

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Ebolavirus requires acid sphingomyelinase activity and plasma membrane sphingomyelin for infection

27 July 2018

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A new player in the puzzle of filovirus entry

27 July 2018

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Ebola virus entry requires the host-programmed recognition of an intracellular receptor

27 July 2018

1 reference

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Protein replacement therapy partially corrects the cholesterol-storage phenotype in a mouse model of Niemann-Pick type C2 disease

27 July 2018

1 reference

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The Ebola virus glycoprotein mediates entry via a non-classical dynamin-dependent macropinocytic pathway

27 July 2018

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Ebola virus entry requires the cholesterol transporter Niemann-Pick C1

27 July 2018

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Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection

27 July 2018

1 reference

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T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus

27 July 2018

1 reference

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Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations

27 July 2018

1 reference

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Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner

27 July 2018

1 reference

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Cellular Entry of Ebola Virus Involves Uptake by a Macropinocytosis-Like Mechanism and Subsequent Trafficking through Early and Late Endosomes

27 July 2018

1 reference

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Environmental enrichment induces behavioral recovery and enhanced hippocampal cell proliferation in an antidepressant-resistant animal model for PTSD.

27 July 2018

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Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression

27 July 2018

1 reference

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Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes

27 July 2018

1 reference

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Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse

27 July 2018

1 reference

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Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor

27 July 2018

1 reference

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Structures and Mechanisms of Viral Membrane Fusion Proteins: Multiple Variations on a Common Theme

27 July 2018

1 reference

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Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking

27 July 2018

1 reference

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Prevention of prion propagation by dehydrocholesterol reductase inhibitors in cultured cells and a therapeutic trial in mice

27 July 2018

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Tyro3 family-mediated cell entry of Ebola and Marburg viruses

27 July 2018

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Metabotropic glutamate 5 receptor antagonism is associated with antidepressant-like effects in mice

27 July 2018

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Cellular mechanism of U18666A-mediated apoptosis in cultured murine cortical neurons: bridging Niemann-Pick disease type C and Alzheimer's disease

27 July 2018

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Ebola virus: unravelling pathogenesis to combat a deadly disease

27 July 2018

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Conserved receptor-binding domains of Lake Victoria marburgvirus and Zaire ebolavirus bind a common receptor

27 July 2018

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Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection

27 July 2018

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Consequences of NPC1 and NPC2 loss of function in mammalian neurons

27 July 2018

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Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport

27 July 2018

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Accumulation of cholera toxin and GM1 ganglioside in the early endosome of Niemann-Pick C1-deficient cells

27 July 2018

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Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events

27 July 2018

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Identification of HE1 as the second gene of Niemann-Pick C disease

27 July 2018

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27 July 2018

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Cholesterol movement in Niemann-Pick type C cells and in cells treated with amphiphiles

27 July 2018

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Niemann-Pick C1 is a late endosome-resident protein that transiently associates with lysosomes and the trans-Golgi network

27 July 2018

1 reference

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The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo

27 July 2018

1 reference

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A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever

27 July 2018

1 reference

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A system for functional analysis of Ebola virus glycoprotein

27 July 2018

1 reference

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Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

27 July 2018

1 reference

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Genetic heterogeneity in Niemann-Pick C disease: a study using somatic cell hybridization and linkage analysis.

27 July 2018

1 reference

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The asialoglycoprotein receptor is a potential liver-specific receptor for Marburg virus

27 July 2018

1 reference

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What maintains the frequencies of human genetic diseases?

27 July 2018

1 reference

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FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection.

27 July 2018

1 reference

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The glucagon-like peptide 1 receptor agonist exendin-4 improves reference memory performance and decreases immobility in the forced swim test.

25 September 2018

1 reference

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Protective effects of imipramine in murine endotoxin-induced acute lung injury

25 September 2018

1 reference

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NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

25 September 2018

1 reference

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Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury.

25 September 2018

1 reference

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Differential subcellular localization of cholesterol, gangliosides, and glycosaminoglycans in murine models of mucopolysaccharide storage disorders

25 September 2018

1 reference

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Trafficking of cholesterol from cell bodies to distal axons in Niemann Pick C1-deficient neurons

25 September 2018

1 reference

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C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans

25 September 2018

1 reference

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Role of Niemann-Pick type C1 protein in intracellular trafficking of low density lipoprotein-derived cholesterol

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447246

Source of cholesterol for the ocular lens, studied with U18666A: a cataract-producing inhibitor of lipid metabolism

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26015498

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Abnormal cholesterol metabolism in imipramine-treated fibroblast cultures. Similarities with Niemann-Pick type C disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26015498

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Quantitative analysis of hydrophobic amine inhibition of intracellular cholesterol transport

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26015498

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MBIO.00565-15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26015498%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26015498%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

PubMed publication ID

26015498

1 reference