Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson's disease. (Q35679526)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25101677%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

title

Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson's disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25101677%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

Rubén Fernández-Santiago

7

1 reference

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12 March 2020

Mario Ezquerra

8

1 reference

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12 March 2020

Jordi Alberch

11

1 reference

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12 March 2020

Herrmann Luebbert

12

1 reference

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12 March 2020

Cristina Malagelada

16

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12 March 2020

author name string

J Romaní-Aumedes

1

1 reference

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12 March 2020

M Canal

2

1 reference

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12 March 2020

N Martín-Flores

3

1 reference

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12 March 2020

X Sun

4

1 reference

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12 March 2020

V Pérez-Fernández

5

1 reference

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12 March 2020

S Wewering

6

1 reference

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12 March 2020

C Pont-Sunyer

9

1 reference

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12 March 2020

A Lafuente

10

1 reference

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12 March 2020

E Tolosa

13

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12 March 2020

O A Levy

14

1 reference

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12 March 2020

L A Greene

15

1 reference

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12 March 2020

language of work or name

1 reference

7 August 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25101677%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

published in

Cell Death and Disease

1 reference

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12 March 2020

volume

5

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12 March 2020

page(s)

e1364

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Creative Commons Attribution 3.0 Unported

12 March 2020

copyright license

start time

1 August 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4454308/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin

12 July 2018

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Phase 1 dose-escalation study of a siRNA targeting the RTP801 gene in age-related macular degeneration patients

12 July 2018

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Primary skin fibroblasts as a model of Parkinson's disease

12 July 2018

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Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells

12 July 2018

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Alpha-synuclein's degradation in vivo: opening a new (cranial) window on the roles of degradation pathways in Parkinson disease

12 July 2018

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RTP801/REDD1 regulates the timing of cortical neurogenesis and neuron migration

12 July 2018

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The role of parkin in familial and sporadic Parkinson's disease

12 July 2018

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Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis

12 July 2018

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Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease

12 July 2018

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Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.

12 July 2018

1 reference

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Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c release

12 July 2018

1 reference

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REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase

12 July 2018

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Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps

12 July 2018

1 reference

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RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation

12 July 2018

1 reference

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12 July 2018

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Invited article: changing concepts in Parkinson disease: moving beyond the decade of the brain

12 July 2018

1 reference

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Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis

12 July 2018

1 reference

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Deciphering the role of heterozygous mutations in genes associated with parkinsonism

12 July 2018

1 reference

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RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation.

12 July 2018

1 reference

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Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease

12 July 2018

1 reference

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Dopamine covalently modifies and functionally inactivates parkin

12 July 2018

1 reference

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Proteomic analysis of parkin knockout mice: alterations in energy metabolism, protein handling and synaptic function

12 July 2018

1 reference

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Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1

12 July 2018

1 reference

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Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease

12 July 2018

1 reference

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S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

12 July 2018

1 reference

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Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454308

Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones

12 July 2018

1 reference

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Parkinson's disease: mechanisms and models

12 July 2018

1 reference

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Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

12 July 2018

1 reference

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Dexamethasone-induced Gene 2 (dig2) Is a Novel Pro-survival Stress Gene Induced Rapidly by Diverse Apoptotic Signals

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454308

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

12 July 2018

1 reference

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REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species

12 July 2018

1 reference

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Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis.

12 July 2018

1 reference

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Lewy bodies and parkinsonism in families with parkin mutations

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454308

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454308

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454308

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454308

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454308

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454308

Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454308

Non-motor behavioural impairments in parkin-deficient mice.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454308

rAAV-mediated nigral human parkin over-expression partially ameliorates motor deficits via enhanced dopamine neurotransmission in a rat model of Parkinson's disease

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454308

Analysis of gene expression changes in a cellular model of Parkinson disease

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454308

Altered proteasomal function in sporadic Parkinson's disease

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454308

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454308

Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454308

Parkin modulates gene expression in control and ceramide-treated PC12 cells

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25101677

12 December 2020

inferred from PubMed ID database lookup

Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25101677

12 December 2020

inferred from PubMed ID database lookup

Medical treatment of Parkinson's disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25101677

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/CDDIS.2014.333

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25101677%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25101677%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

PubMed publication ID

25101677

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25101677%20AND%20SRC:MED&resulttype=core&format=json