Modeling the cancer patient with genetically engineered mice: prediction of toxicity from molecule-targeted therapies (Q35681316)

9 August 2017

1 reference

title

Modeling the cancer patient with genetically engineered mice: prediction of toxicity from molecule-targeted therapies (English)

1 reference

9 August 2017

1 reference

David W Threadgill

3

0 references

author name string

Reade B Roberts

series ordinal

1

1 reference

PubMed ID

14998487

9 August 2017

Carlos L Arteaga

series ordinal

2

1 reference

9 August 2017

1 February 2004

1 reference

9 August 2017

1 reference

9 August 2017

5

1 reference

9 August 2017

2

1 reference

9 August 2017

115-120

1 reference

Renal failure associated with the use of celecoxib and rofecoxib

9 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Cutaneous side-effects in cancer patients treated with the antiepidermal growth factor receptor antibody C225

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Inhibiting the p53-MDM2 interaction: an important target for cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

ErbB2 is essential in the prevention of dilated cardiomyopathy.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Colonic Epithelial Expression of ErbB2 Is Required for Postnatal Maintenance of the Enteric Nervous System

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Targeting the TGF beta signaling network in human neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Mice harboring a defective epidermal growth factor receptor (waved-2) have an increased susceptibility to acute dextran sulfate-induced colitis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Dose-dense sequential chemotherapy with epirubicin and paclitaxel versus the combination, as first-line chemotherapy, in advanced breast cancer: a randomized study conducted by the Hellenic Cooperative Oncology Group

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

A defective EGF-receptor in waved-2 mice attenuates intestinal adaptation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Inhibition of parietal cell acid secretion is mediated by the classical epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Requirement for neuregulin receptor erbB2 in neural and cardiac development

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

The Occurrence of a Dominant Spotting Mutation in the House Mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Preventing Toxicity With a Gene Test

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Hair depigmentation is a biological readout for pharmacological inhibition of KIT in mice and humans

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Trastuzumab in the treatment of advanced breast cancer: single-center experience

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Tyrosine kinase inhibition and grey hair

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Strain-dependent epithelial defects in mice lacking the EGF receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Clinical efficacy and toxicity of gefitinib in patients with lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Novel ENU-induced eye mutations in the mouse: models for human eye disease

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Growth retardation, duodenal lesions, and aberrant ileum architecture in triple null mice lacking EGF, amphiregulin, and TGF-alpha

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

p53 mutant mice that display early ageing-associated phenotypes

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Knockouts model the 100 best-selling drugs--will they model the next 100?

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900032-7

7 January 2021

10.1016/S1535-6108(04)00032-7

Identifiers

DOI

1 reference

9 August 2017

1 reference

PubMed ID

14998487