The two faces of Janus kinases and their respective STATs in mammary gland development and cancer (Q35685851)

9 August 2017

title

The two faces of Janus kinases and their respective STATs in mammary gland development and cancer (English)

1 reference

9 August 2017

Kay-Uwe Wagner

1

1 reference

9 August 2017

Jeffrey W Schmidt

series ordinal

2

1 reference

9 August 2017

language of work or name

English

0 references

publication date

8 December 2011

1 reference

Journal of Carcinogenesis

9 August 2017

published in

1 reference

9 August 2017

volume

10

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9 August 2017

page(s)

32

1 reference

The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors

9 August 2017

cites work

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A

12 July 2018

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Targeting janus kinase 2 in Her2/neu-expressing mammary cancer: Implications for cancer prevention and therapy

12 July 2018

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Activation of phosphatidylinositol 3-kinase by membrane localization of p110alpha predisposes mammary glands to neoplastic transformation

12 July 2018

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12 July 2018

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Inteferons pen the JAK-STAT pathway

12 July 2018

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The Stat family of transcription factors have diverse roles in mammary gland development

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland

12 July 2018

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12 July 2018

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12 July 2018

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Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways.

12 July 2018

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Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer.

12 July 2018

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The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells

12 July 2018

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12 July 2018

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12 July 2018

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Stat5 promotes homotypic adhesion and inhibits invasive characteristics of human breast cancer cells.

12 July 2018

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STAT1: a modulator of chemotherapy-induced apoptosis

12 July 2018

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12 July 2018

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12 July 2018

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Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation

12 July 2018

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Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice

12 July 2018

1 reference

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Signal transducer and activator of transcription-5 activation and breast cancer prognosis

12 July 2018

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p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity

12 July 2018

1 reference

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Prolactin induces ERalpha-positive and ERalpha-negative mammary cancer in transgenic mice

12 July 2018

1 reference

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The role of prolactin in mammary carcinoma

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262999

Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262999

The signaling domain of the erythropoietin receptor rescues prolactin receptor-mutant mammary epithelium

12 July 2018

1 reference

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Prognostic significance of signal transducer and activator of transcription 1 activation in breast cancer

12 July 2018

1 reference

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Stats: transcriptional control and biological impact

12 July 2018

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Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland

12 July 2018

1 reference

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Protein kinases--the major drug targets of the twenty-first century?

12 July 2018

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Signaling through the JAK/STAT pathway, recent advances and future challenges

12 July 2018

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Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells

12 July 2018

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Autocrine production of interleukin 6 causes multidrug resistance in breast cancer cells.

12 July 2018

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Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium

12 July 2018

1 reference

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Negative regulation of cytokine signaling.

12 July 2018

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Specific protection against breast cancers by cyclin D1 ablation

12 July 2018

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12 July 2018

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12 July 2018

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Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression

12 July 2018

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Inhibition of oncogene STAT3 phosphorylation by a prolactin antagonist, hPRL-G129R, in T-47D human breast cancer cells

12 July 2018

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12 July 2018

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Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses

12 July 2018

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Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

12 July 2018

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12 July 2018

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12 July 2018

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Activation of the prolactin receptor but not the growth hormone receptor is important for induction of mammary tumors in transgenic mice.

12 July 2018

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Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene

12 July 2018

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Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

12 July 2018

1 reference

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Stat5a is mandatory for adult mammary gland development and lactogenesis.

12 July 2018

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Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse

12 July 2018

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Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation.

12 July 2018

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Differential activation of STATs 3 and 5 during mammary gland development.

12 July 2018

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Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue

12 July 2018

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12 July 2018

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12 July 2018

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Analysis of Brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit.

12 July 2018

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Activating mutation (V617F) in the tyrosine kinase JAK2 is absent in locally-confined or castration-resistant prostate cancer.

25 September 2018

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Mammary epithelial reconstitution with gene-modified stem cells assigns roles to Stat5 in luminal alveolar cell fate decisions, differentiation, involution, and mammary tumor formation

25 September 2018

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Mutational analysis of JAK1 gene in human hepatocellular carcinoma

25 September 2018

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Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers

25 September 2018

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The IL-4/IL-13/Stat6 signalling pathway promotes luminal mammary epithelial cell development.

25 September 2018

1 reference

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The Jak/Stat pathway: a novel way to regulate PI3K activity.

25 September 2018

1 reference

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Parity-induced mammary epithelial cells facilitate tumorigenesis in MMTV-neu transgenic mice

25 September 2018

1 reference

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Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion

25 September 2018

1 reference

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Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancers

25 September 2018

1 reference

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A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary gland

25 September 2018

1 reference

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Deletion of Stat3 blocks mammary gland involution and extends functional competence of the secretory epithelium in the absence of lactogenic stimuli.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262999

Loss of Stat5a delays mammary cancer progression in a mouse model.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262999

Basal activation of transcription factor signal transducer and activator of transcription (Stat5) in nonpregnant mouse and human breast epithelium

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262999

PRL activates the cyclin D1 promoter via the Jak2/Stat pathway.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262999

Jak2 is an essential tyrosine kinase involved in pregnancy-mediated development of mammary secretory epithelium

25 September 2018

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Mammary gland involution is delayed by activated Akt in transgenic mice.

25 September 2018

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Signal transducer and activator of transcription 5a influences mammary epithelial cell survival and tumorigenesis.

25 September 2018

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Mammary gland-specific nuclear factor is present in lactating rodent and bovine mammary tissue and composed of a single polypeptide of 89 kDa

25 September 2018

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12 December 2020

Deregulation of Stat5 expression and activation causes mammary tumors in transgenic mice

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12 December 2020

Functional rescue of Stat5a-null mammary tissue through the activation of compensating signals including Stat5b

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12 December 2020

The epidemiology of breast cancer

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12 December 2020

Are the TDLU of the human the same as the LA of mice?

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12 December 2020

Delayed mammary gland involution in MMTV-AKT1 transgenic mice

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12 December 2020

Prolactin synthesis and secretion by human breast cancer cells

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12 December 2020

Overexpression and forced activation of stat5 in mammary gland of transgenic mice promotes cellular proliferation, enhances differentiation, and delays postlactational apoptosis

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12 December 2020

Identifiers

DOI

10.4103/1477-3163.90677

1 reference

9 August 2017

1 reference

9 August 2017

1 reference