Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes. (Q35694015)

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scientific article published on 9 June 2015

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English	Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes.	scientific article published on 9 June 2015

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scholarly article

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16 February 2020

Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes (English)

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Abraham N Morse

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Robin J Shattock

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Paul R Clapham

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Paul J Peters

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Maria Paz Gonzalez-Perez

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Thomas Musich

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Tiffany A Moore Simas

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Rongheng Lin

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Cynthia A Derdeyn

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9 June 2015

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16 February 2020

https://scigraph.springernature.com/pub.10.1186/s12977-015-0176-2

0 references

HIV-1 non-macrophage-tropic R5 envelope glycoproteins are not more tropic for entry into primary CD4+ T-cells than envelopes highly adapted for macrophages

1 reference

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12 July 2018

Transmitted virus fitness and host T cell responses collectively define divergent infection outcomes in two HIV-1 recipients

1 reference

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12 July 2018

Vpx complementation of 'non-macrophage tropic' R5 viruses reveals robust entry of infectious HIV-1 cores into macrophages.

1 reference

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Postnatally-transmitted HIV-1 Envelope variants have similar neutralization-sensitivity and function to that of nontransmitted breast milk variants

1 reference

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12 July 2018

HIV-1 expressing the envelopes of transmitted/founder or control/reference viruses have similar infection patterns of CD4 T-cells in human cervical tissue ex vivo

1 reference

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Mucosal tissue tropism and dissemination of HIV-1 subtype B acute envelope-expressing chimeric virus

1 reference

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Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism

1 reference

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12 July 2018

Independent evolution of macrophage-tropism and increased charge between HIV-1 R5 envelopes present in brain and immune tissue.

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12 July 2018

Evaluation of cervical mucosa in transmission bottleneck during acute HIV-1 infection using a cervical tissue-based organ culture

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Generation of transmitted/founder HIV-1 infectious molecular clones and characterization of their replication capacity in CD4 T lymphocytes and monocyte-derived macrophages

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HIV-1 replication in the central nervous system occurs in two distinct cell types.

1 reference

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Genotypic and functional properties of early infant HIV-1 envelopes

1 reference

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12 July 2018

Spinoculation triggers dynamic actin and cofilin activity that facilitates HIV-1 infection of transformed and resting CD4 T cells

1 reference

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Phenotypic and immunologic comparison of clade B transmitted/founder and chronic HIV-1 envelope glycoproteins

1 reference

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12 July 2018

Intercompartmental recombination of HIV-1 contributes to env intrahost diversity and modulates viral tropism and sensitivity to entry inhibitors

1 reference

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A conserved determinant in the V1 loop of HIV-1 modulates the V3 loop to prime low CD4 use and macrophage infection

1 reference

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12 July 2018

Early HIV-1 target cells in human vaginal and ectocervical mucosa

1 reference

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The B cell response is redundant and highly focused on V1V2 during early subtype C infection in a Zambian seroconverter

1 reference

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12 July 2018

Variation in the biological properties of HIV-1 R5 envelopes: implications of envelope structure, transmission and pathogenesis

1 reference

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HIV-1 gp120 determinants proximal to the CD4 binding site shift protective glycans that are targeted by monoclonal antibody 2G12.

1 reference

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12 July 2018

Subtype-specific conservation of isoleucine 309 in the envelope V3 domain is linked to immune evasion in subtype C HIV-1 infection

1 reference

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12 July 2018

Targeting early infection to prevent HIV-1 mucosal transmission.

1 reference

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12 July 2018

Donor and recipient envs from heterosexual human immunodeficiency virus subtype C transmission pairs require high receptor levels for entry

1 reference

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Escape from autologous neutralizing antibodies in acute/early subtype C HIV-1 infection requires multiple pathways

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12 July 2018

HIV-1 infection of macrophages is dependent on evasion of innate immune cellular activation

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Heterosexual transmission of human immunodeficiency virus type 1 subtype C: Macrophage tropism, alternative coreceptor use, and the molecular anatomy of CCR5 utilization.

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Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection

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Macrophages in vaginal but not intestinal mucosa are monocyte-like and permissive to human immunodeficiency virus type 1 infection

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12 July 2018

Determinants flanking the CD4 binding loop modulate macrophage tropism of human immunodeficiency virus type 1 R5 envelopes

1 reference

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Rethinking the heterosexual infectivity of HIV-1: a systematic review and meta-analysis

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Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection

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Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors.

1 reference

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Unique mutational patterns in the envelope alpha 2 amphipathic helix and acquisition of length in gp120 hypervariable domains are associated with resistance to autologous neutralization of subtype C human immunodeficiency virus type 1.

1 reference

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Non-macrophage-tropic human immunodeficiency virus type 1 R5 envelopes predominate in blood, lymph nodes, and semen: implications for transmission and pathogenesis.

1 reference

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1 reference

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1 reference

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A new classification for HIV-1

1 reference

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1 reference

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1 reference

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25 September 2018

Sexual Transmission and Propagation of SIV and HIV in Resting and Activated CD4+ T Cells

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https://api.crossref.org/works/10.1186%2FS12977-015-0176-2

21 January 2018

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10.1186/S12977-015-0176-2

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16 February 2020

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16 February 2020

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16 February 2020

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