Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors. (Q39351549)

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scientific article published on 18 January 2008

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English	Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors.	scientific article published on 18 January 2008

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1 January 2020

Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors (English)

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Paul R Clapham

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Katherine Luzuriaga

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Paul J Peters

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Maria J Duenas-Decamp

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W Matthew Sullivan

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Chiambah Ankghuambom

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James Robinson

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Jeanne Bell

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1 January 2020

https://scigraph.springernature.com/pub.10.1186/1742-4690-5-5

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In vivo and in vitro escape from neutralizing antibodies 2G12, 2F5, and 4E10.

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11 September 2017

Structural definition of a conserved neutralization epitope on HIV-1 gp120

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11 September 2017

Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry

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11 September 2017

The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementia.

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11 September 2017

Non-macrophage-tropic human immunodeficiency virus type 1 R5 envelopes predominate in blood, lymph nodes, and semen: implications for transmission and pathogenesis.

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11 September 2017

Characterizing anti-HIV monoclonal antibodies and immune sera by defining the mechanism of neutralization.

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11 September 2017

Envelope conformational changes induced by human immunodeficiency virus type 1 attachment inhibitors prevent CD4 binding and downstream entry events

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11 September 2017

HIV disease: fallout from a mucosal catastrophe?

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11 September 2017

Uncoupling coreceptor usage of human immunodeficiency virus type 1 (HIV-1) from macrophage tropism reveals biological properties of CCR5-restricted HIV-1 isolates from patients with acquired immunodeficiency syndrome

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11 September 2017

Structure of an unliganded simian immunodeficiency virus gp120 core

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11 September 2017

CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract

1 reference

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11 September 2017

Biological analysis of human immunodeficiency virus type 1 R5 envelopes amplified from brain and lymph node tissues of AIDS patients with neuropathology reveals two distinct tropism phenotypes and identifies envelopes in the brain that confer an enh

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268948

11 September 2017

Localized changes in the gp120 envelope glycoprotein confer resistance to human immunodeficiency virus entry inhibitors BMS-806 and #155.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268948

11 September 2017

Biochemical and genetic characterizations of a novel human immunodeficiency virus type 1 inhibitor that blocks gp120-CD4 interactions

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11 September 2017

Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry.

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11 September 2017

Antibody neutralization and escape by HIV-1

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The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120.

1 reference

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11 September 2017

The mannose-dependent epitope for neutralizing antibody 2G12 on human immunodeficiency virus type 1 glycoprotein gp120.

1 reference

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Increased CCR5 affinity and reduced CCR5/CD4 dependence of a neurovirulent primary human immunodeficiency virus type 1 isolate.

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Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy.

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Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.

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Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design

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CCR5 is the major coreceptor used by HIV-1 subtype C isolates from patients with active tuberculosis

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Absence of coreceptor switch with disease progression in human immunodeficiency virus infections in India

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In vivo HIV-1 infection of CD45RA(+)CD4(+) T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4(+) T cell decline

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Blood-brain barrier tight junction disruption in human immunodeficiency virus-1 encephalitis

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Persistent CCR5 utilization and enhanced macrophage tropism by primary blood human immunodeficiency virus type 1 isolates from advanced stages of disease and comparison to tissue-derived isolates

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11 September 2017

Genetics of HIV-1 infection: chemokine receptor CCR5 polymorphism and its consequences.

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Both memory and CD45RA+/CD62L+ naive CD4(+) T cells are infected in human immunodeficiency virus type 1-infected individuals

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A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

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Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages

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11 September 2017

Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

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Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection

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Determinants of human immunodeficiency virus type 1 resistance to gp41-derived inhibitory peptides.

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Localization of HIV-1 co-receptors CCR5 and CXCR4 in the brain of children with AIDS.

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In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression.

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The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes

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Infectious properties of human immunodeficiency virus type 1 mutants with distinct affinities for the CD4 receptor

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Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1

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Human immunodeficiency virus type 1 variants with increased replicative capacity develop during the asymptomatic stage before disease progression

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Neutralization of divergent human immunodeficiency virus type 1 variants and primary isolates by IAM-41-2F5, an anti-gp41 human monoclonal antibody

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Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus binding

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Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry

1 reference

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Macrophage entry mediated by HIV Envs from brain and lymphoid tissues is determined by the capacity to use low CD4 levels and overall efficiency of fusion.

1 reference

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1 reference

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1 reference

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HIV-1 clones resistant to a small molecule CCR5 inhibitor use the inhibitor-bound form of CCR5 for entry

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Human immunodeficiency virus (HIV) infection in brains with AIDS-related leukoencephalopathy

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Replicative capacity of human immunodeficiency virus from patients with varying severity of HIV infection

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Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms.

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HIV-1 tropism for the central nervous system: Brain-derived envelope glycoproteins with lower CD4 dependence and reduced sensitivity to a fusion inhibitor

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Extravasation of blood-borne immunoglobulin G through blood-brain barrier during adrenaline-induced transient hypertension in the rat.

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Discovery of 4-benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806): a novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions

1 reference

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21 August 2018

Structure-based, targeted deglycosylation of HIV-1 gp120 and effects on neutralization sensitivity and antibody recognition.

1 reference

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Neuroinvasion by simian immunodeficiency virus coincides with increased numbers of perivascular macrophages/microglia and intrathecal immune activation.

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Blood-brain barrier abnormalities in the acquired immunodeficiency syndrome: immunohistochemical localization of serum proteins in postmortem brain

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HIV-1 subtype C syncytium- and non-syncytium-inducing phenotypes and coreceptor usage among Ethiopian patients with AIDS

1 reference

https://api.crossref.org/works/10.1186%2F1742-4690-5-5

21 January 2018

Restricted antigenic variability of the epitope recognized by the neutralizing gp41 antibody 2F5

1 reference

https://api.crossref.org/works/10.1186%2F1742-4690-5-5

21 January 2018

Detection and localisation of HIV-1 DNA and RNA in fixed adult AIDS brain by polymerase chain reaction/in situ hybridisation technique

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https://pubmed.ncbi.nlm.nih.gov/18205925

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1742-4690-5-5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18205925%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Dimensions Publication ID

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1742-4690-5-5

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18205925%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18205925%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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