cAMP detection methods in HTS: selecting the best from the rest (Q35709584)

9 August 2017

1 reference

title

cAMP detection methods in HTS: selecting the best from the rest (English)

1 reference

9 August 2017

Christine Williams

1

1 reference

9 August 2017

1 February 2004

1 reference

Nature Reviews Drug Discovery

9 August 2017

1 reference

9 August 2017

3

1 reference

9 August 2017

125-135

1 reference

9 August 2017

2

1 reference

https://scigraph.springernature.com/pub.10.1038/nrd1306

9 August 2017

0 references

cites work

Hit and lead generation: beyond high-throughput screening

1 reference

31 March 2020

1 reference

High-throughput screening: advances in assay technologies.

31 March 2020

1 reference

Novel detection strategies for drug discovery

31 March 2020

1 reference

Designing screens: how to make your hits a hit.

31 March 2020

1 reference

Functional cell-based uHTS in chemical genomic drug discovery

31 March 2020

1 reference

High-throughput screening: new technology for the 21st century

31 March 2020

1 reference

Cellular platforms for HTS: three case studies

31 March 2020

1 reference

Allosteric binding sites on cell-surface receptors: novel targets for drug discovery

31 March 2020

1 reference

Regulation and role of adenylyl cyclase isoforms

31 March 2020

1 reference

Molecular biological approaches to unravel adenylyl cyclase signaling and function

31 March 2020

1 reference

Cyclic nucleotide phosphodiesterases: pharmacology, biochemistry and function

31 March 2020

1 reference

High Throughput Quantitation of cAMP Production Mediated by Activation of Seven Transmembrane Domain Receptors

31 March 2020

1 reference

Impact of a red-shifted dye label for high throughput fluorescence polarization assays of G protein-coupled receptors

31 March 2020

1 reference

A Homogeneous Enzyme Fragment Complementation Cyclic AMP Screen for GPCR Agonists

31 March 2020

1 reference

A novel high throughput chemiluminescent assay for the measurement of cellular cyclic adenosine monophosphate levels

31 March 2020

1 reference

Effects of a range of beta2 adrenoceptor agonists on changes in intracellular cyclic AMP and on cyclic AMP driven gene expression in cultured human airway smooth muscle cells

31 March 2020

1 reference

Reporter-gene systems for the study of G-protein-coupled receptors.

31 March 2020

1 reference

Marker proteins for gene expression

31 March 2020

1 reference

The dynamic microbe: green fluorescent protein brings bacteria to light

31 March 2020

1 reference

Imaging of light emission from the expression of luciferases in living cells and organisms: a review

31 March 2020

1 reference

The first reporter gene assay on living cells: green fluorescent protein as reporter gene for the investigation of Gi-protein coupled receptors

31 March 2020

1 reference

A colorimetric assay for measuring activation of Gs- and Gq-coupled signaling pathways

31 March 2020

1 reference

Development of a dual glow-signal firefly and Renilla luciferase assay reagent for the analysis of G-protein coupled receptor signalling

31 March 2020

1 reference

The origin, diversity, and structure function relationships of insect luciferases

31 March 2020

1 reference

Quantitation of transcription and clonal selection of single living cells with beta-lactamase as reporter

31 March 2020

1 reference

Development of an intact cell reporter gene beta-lactamase assay for G protein-coupled receptors for high-throughput screening

31 March 2020

1 reference

Detection of beta-lactamase reporter gene expression by flow cytometry

31 March 2020

1 reference

A genome-wide functional assay of signal transduction in living mammalian cells

31 March 2020

1 reference

Development of a facile method for high throughput screening with reporter gene assays

31 March 2020

1 reference

The effect of ICER on screening methods involving CRE-mediated reporter gene expression

31 March 2020

1 reference

Partial agonism at serotonin 5-HT1B and dopamine D2L receptors using a luciferase reporter gene assay

31 March 2020

1 reference

Development of a functional reporter gene HTS assay for the identification of mGluR7 modulators

31 March 2020

1 reference

Influence of agonist efficacy and receptor phosphorylation on antagonist affinity measurements: differences between second messenger and reporter gene responses

31 March 2020

1 reference

Evaluation of β-adrenergic receptor subtypes in the human prostate cancer cell line-LNCaP

31 March 2020

1 reference

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

31 March 2020

1 reference

G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C

31 March 2020

1 reference

Chimaeric G alpha proteins: their potential use in drug discovery

31 March 2020

1 reference

Is Galpha16 the optimal tool for fishing ligands of orphan G-protein-coupled receptors?

31 March 2020

1 reference

The Cheng-Prusoff relationship: something lost in the translation.

31 March 2020

1 reference

Further concerns over Cheng-Prusoff analysis

31 March 2020

1 reference

High-content profiling of drug-drug interactions: cellular targets involved in the modulation of microtubule drug action by the antifungal ketoconazole

31 March 2020

1 reference

Quantification of G-Protein Coupled Receptor Internatilization Using G-Protein Coupled Receptor-Green Fluorescent Protein Conjugates with the ArrayScantrade mark High-Content Screening System.

31 March 2020

1 reference

A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation

31 March 2020

1 reference

Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors

31 March 2020

1 reference

A combination assay for simultaneous assessment of multiple signaling pathways

31 March 2020

1 reference

Fluorescence imaging of signaling networks.

31 March 2020

1 reference

Principles: extending the utility of [35S]GTP gamma S binding assays

31 March 2020

1 reference

Measuring intracellular calcium fluxes in high throughput mode

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD1306

1 reference

9 August 2017

1 reference

PubMed ID

15040577