Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity (Q35721612)

9 August 2017

Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity (English)

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9 August 2017

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9 August 2017

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Hidde Ploegh

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9 August 2017

Irina Gavanescu

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9 August 2017

Christophe Benoist

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4

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9 August 2017

Diane Mathis

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5

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9 August 2017

language of work or name

English

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publication date

6 March 2007

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Proceedings of the National Academy of Sciences of the United States of America

9 August 2017

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9 August 2017

104

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9 August 2017

11

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9 August 2017

4583-4587

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Spontaneous autoimmunity prevented by thymic expression of a single self-antigen

9 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838644

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838644

Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838644

Shaping the T cell repertoire to a bona fide autoantigen: lessons from autoimmune gastritis.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838644

Modifier loci condition autoimmunity provoked by Aire deficiency

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838644

Rapid identification of proteins by peptide-mass fingerprinting

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838644

The mouse secreted gel-forming mucin gene cluster

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838644

AIRE functions as an E3 ubiquitin ligase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838644

Negative selection and autoimmunity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838644

Functional proteomics of the active cysteine protease content in Drosophila S2 cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838644

Negative selection--clearing out the bad apples from the T-cell repertoire

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838644

Aire regulates negative selection of organ-specific T cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838644

Positive and negative selection of T cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838644

Projection of an immunological self shadow within the thymus by the aire protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838644

Promiscuous gene expression and central T-cell tolerance: more than meets the eye.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838644

Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838644

The enemy within: keeping self-reactive T cells at bay in the periphery

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838644

The MUC family: an obituary.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838644

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838644

The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838644

Mutations in the AIRE gene: effects on subcellular location and transactivation function of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838644

Peripheral T-cell tolerance: the contribution of permissive T-cell migration into parenchymal tissues of the neonate

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838644

The thymus and self-tolerance: co-existence of encephalitogenic S100 beta-specific T cells and their nominal autoantigen in the normal adult rat thymus

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838644

Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838644

NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) disease

12 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0700259104

The cellular mechanism of Aire control of T cell tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0700259104

Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0700259104

Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0700259104

Aire deficient mice do not develop the same profile of tissue-specific autoantibodies as APECED patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0700259104

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0700259104

Intrathymic expression of genes involved in organ specific autoimmune disease

21 January 2018

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12 December 2020

B7 expression on thymic medullary epithelium correlates with epithelium-mediated deletion of V beta 5+ thymocytes

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12 December 2020

Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice

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12 December 2020

Transcription of a broad range of self-antigens in human thymus suggests a role for central mechanisms in tolerance toward peripheral antigens

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12 December 2020

Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0700259104

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9 August 2017

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9 August 2017

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