PARP targeting counteracts gliomagenesis through induction of mitotic catastrophe and aggravation of deficiency in homologous recombination in PTEN-mutant glioma (Q35741555)

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scientific article published on March 2015

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English	PARP targeting counteracts gliomagenesis through induction of mitotic catastrophe and aggravation of deficiency in homologous recombination in PTEN-mutant glioma	scientific article published on March 2015

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27 February 2020

PARP targeting counteracts gliomagenesis through induction of mitotic catastrophe and aggravation of deficiency in homologous recombination in PTEN-mutant glioma (English)

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27 February 2020

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27 February 2020

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Jara Majuelos-Melguizo

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27 February 2020

María Isabel Rodríguez

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27 February 2020

Laura López-Jiménez

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27 February 2020

Jose M Rodríguez-Vargas

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27 February 2020

Juan M Martí Martín-Consuegra

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27 February 2020

Santiago Serrano-Sáenz

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27 February 2020

J Mariano Ruiz de Almodóvar

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27 February 2020

F Javier Oliver

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27 February 2020

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1 March 2015

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27 February 2020

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27 February 2020

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27 February 2020

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27 February 2020

4790-4803

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27 February 2020

Histone deacetylase inhibitor treatment induces 'BRCAness' and synergistic lethality with PARP inhibitor and cisplatin against human triple negative breast cancer cells

1 reference

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Phosphorylation of ribosomal protein S6 confers PARP inhibitor resistance in BRCA1-deficient cancers

1 reference

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12 July 2018

Rationale for poly(ADP-ribose) polymerase (PARP) inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition

1 reference

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Linking off-target kinase pharmacology to the differential cellular effects observed among PARP inhibitors.

1 reference

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Pharmacological inhibition of poly(ADP-ribose) polymerase-1 modulates resistance of human glioblastoma stem cells to temozolomide

1 reference

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12 July 2018

Therapeutic targeting of constitutive PARP activation compromises stem cell phenotype and survival of glioblastoma-initiating cells

1 reference

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Cell death associated with abnormal mitosis observed by confocal imaging in live cancer cells.

1 reference

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12 July 2018

Aneuploidy in health, disease, and aging

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12 July 2018

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.

1 reference

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12 July 2018

Cancer-Specific requirement for BUB1B/BUBR1 in human brain tumor isolates and genetically transformed cells

1 reference

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New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

1 reference

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12 July 2018

PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation.

1 reference

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A phenanthrene derived PARP inhibitor is an extra-centrosomes de-clustering agent exclusively eradicating human cancer cells

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Type I IFNs signaling and apoptosis resistance in glioblastoma cells.

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12 July 2018

Upregulation of Poly (ADP-Ribose) Polymerase-1 (PARP1) in Triple-Negative Breast Cancer and Other Primary Human Tumor Types

1 reference

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Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway.

1 reference

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12 July 2018

N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide

1 reference

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12 July 2018

PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467115

12 July 2018

CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of long-term cultured cancer stem cells from human malignant glio-neuronal tumors

1 reference

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12 July 2018

Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130.

1 reference

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U87MG decoded: the genomic sequence of a cytogenetically aberrant human cancer cell line

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Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

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Vasoactivity of AG014699, a clinically active small molecule inhibitor of poly(ADP-ribose) polymerase: a contributory factor to chemopotentiation in vivo?

1 reference

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

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An integrated genomic analysis of human glioblastoma multiforme

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Tenets of PTEN tumor suppression

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467115

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Malignant astrocytic glioma: genetics, biology, and paths to treatment

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Essential role for nuclear PTEN in maintaining chromosomal integrity

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

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Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The human mitotic checkpoint protein BubR1 regulates chromosome-spindle attachments

1 reference

https://pubmed.ncbi.nlm.nih.gov/25576921

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.18632/ONCOTARGET.2993

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27 February 2020

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27 February 2020

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27 February 2020

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