New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs (Q38020082)

27 August 2017

New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs (English)

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27 August 2017

Bryan A Gibson

1

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PubMed ID

22713970

27 August 2017

W Lee Kraus

series ordinal

2

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27 August 2017

20 June 2012

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Nature Reviews Molecular Cell Biology

27 August 2017

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27 August 2017

13

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27 August 2017

411-424

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27 August 2017

7

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https://scigraph.springernature.com/pub.10.1038/nrm3376

27 August 2017

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cites work

Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going?

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The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases.

31 March 2020

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Poly(ADP-ribose): novel functions for an old molecule

31 March 2020

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The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets

31 March 2020

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On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1.

31 March 2020

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The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders

31 March 2020

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Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation

31 March 2020

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The roles of PARP1 in gene control and cell differentiation

31 March 2020

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Poly(ADP-ribosyl)ation by PARP-1: 'PAR-laying' NAD+ into a nuclear signal

31 March 2020

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PARP-1 activation in the ERK signaling pathway

31 March 2020

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PARP inhibition: PARP1 and beyond

31 March 2020

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Poly(ADP-ribose) polymerase-1 (PARP-1) and its therapeutic implications

31 March 2020

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A review of PARP inhibitors: from bench to bedside

31 March 2020

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PARP inhibitors in cancer: moving beyond BRCA.

31 March 2020

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Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

31 March 2020

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PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase

31 March 2020

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Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression

31 March 2020

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PARP-3 and APLF function together to accelerate nonhomologous end-joining

31 March 2020

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Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner

31 March 2020

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PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA

31 March 2020

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B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity

31 March 2020

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Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation.

31 March 2020

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High resolution fractionation and characterization of ADP-ribose polymers

31 March 2020

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The mechanism of the elongation and branching reaction of poly(ADP-ribose) polymerase as derived from crystal structures and mutagenesis

31 March 2020

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Inhibitor and NAD+ binding to poly(ADP-ribose) polymerase as derived from crystal structures and homology modeling

31 March 2020

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In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs)

31 March 2020

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Crystal structure of diphtheria toxin bound to nicotinamide adenine dinucleotide

31 March 2020

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Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments

31 March 2020

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The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase

31 March 2020

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Identification and characterization of a mammalian 39-kDa poly(ADP-ribose) glycohydrolase

31 March 2020

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The 39-kDa poly(ADP-ribose) glycohydrolase ARH3 hydrolyzes O-acetyl-ADP-ribose, a product of the Sir2 family of acetyl-histone deacetylases

31 March 2020

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The Nudix hydrolase superfamily

31 March 2020

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Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO DNA-DEPENDENT PARP-1 ACTIVITY

31 March 2020

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XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro

31 March 2020

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Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1

31 March 2020

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Structural and biophysical studies of human PARP-1 in complex with damaged DNA.

31 March 2020

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The DNA-Binding Domain of Human PARP-1 Interacts with DNA Single-Strand Breaks as a Monomer through Its Second Zinc Finger

31 March 2020

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Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites

31 March 2020

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NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1.

31 March 2020

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31 March 2020

PARP goes transcription

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Nucleosomal core histones mediate dynamic regulation of poly(ADP-ribose) polymerase 1 protein binding to chromatin and induction of its enzymatic activity.

31 March 2020

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Drosophila histone H2A variant (H2Av) controls poly(ADP-ribose) polymerase 1 (PARP1) activation in chromatin

31 March 2020

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Rapid, transcription-independent loss of nucleosomes over a large chromatin domain at Hsp70 loci

31 March 2020

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Activator-induced spread of poly(ADP-ribose) polymerase promotes nucleosome loss at Hsp70.

31 March 2020

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Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1

31 March 2020

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DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: a link to histone acetylation.

31 March 2020

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Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles

31 March 2020

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Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease

31 March 2020

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Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism

31 March 2020

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PIASy mediates SUMO-2/3 conjugation of poly(ADP-ribose) polymerase 1 (PARP1) on mitotic chromosomes.

31 March 2020

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PARP-1 transcriptional activity is regulated by sumoylation upon heat shock

31 March 2020

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SIRT6 promotes DNA repair under stress by activating PARP1

31 March 2020

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Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm.

31 March 2020

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Understanding the mode of action of diphtheria toxin: a perspective on progress during the 20th century

31 March 2020

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Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding

31 March 2020

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PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway

31 March 2020

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The poly(ADP-ribose) polymerases (PARPs): new roles in intracellular transport

31 March 2020

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The nucleosome-remodeling ATPase ISWI is regulated by poly-ADP-ribosylation

31 March 2020

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Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

31 March 2020

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The DNA binding and catalytic domains of poly(ADP-ribose) polymerase 1 cooperate in the regulation of chromatin structure and transcription

31 March 2020

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A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IkappaB kinase activation

31 March 2020

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Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1

31 March 2020

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A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

31 March 2020

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Structure and identification of ADP-ribose recognition motifs of APLF and role in the DNA damage response

31 March 2020

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Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins

31 March 2020

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XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage

31 March 2020

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Spatial and temporal cellular responses to single-strand breaks in human cells.

31 March 2020

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Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function

31 March 2020

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Interaction between Poly(ADP-ribose) and NuMA contributes to mitotic spindle pole assembly

31 March 2020

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Poly(ADP-ribose) is required for spindle assembly and structure.

31 March 2020

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Poly (ADP-ribose) polymerase 1 is required for protein localization to Cajal body

31 March 2020

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The WWE domain: a common interaction module in protein ubiquitination and ADP ribosylation

31 March 2020

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Polyubiquitylation of PARP-1 through ubiquitin K48 is modulated by activated DNA, NAD+, and dipeptides.

31 March 2020

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TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres

31 March 2020

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Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination

31 March 2020

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Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage

31 March 2020

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RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

31 March 2020

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Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death

31 March 2020

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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

31 March 2020

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CHFR protein regulates mitotic checkpoint by targeting PARP-1 protein for ubiquitination and degradation

31 March 2020

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Poly(ADP-ribosyl)ation affects stabilization of Che-1 protein in response to DNA damage.

31 March 2020

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Mitochondrial and nuclear cross talk in cell death: parthanatos

31 March 2020

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Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans.

31 March 2020

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Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor

31 March 2020

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A continuous microplate assay for sirtuins and nicotinamide-producing enzymes

31 March 2020

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The macro domain is an ADP-ribose binding module

31 March 2020

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Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels

31 March 2020

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Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality

31 March 2020

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PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms.

31 March 2020

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Global analysis of transcriptional regulation by poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells

31 March 2020

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Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes

31 March 2020

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Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins

31 March 2020

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Double-stranded DNA binding domain of poly(ADP-ribose) polymerase-1 and molecular insight into the regulation of its activity

31 March 2020

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Stress-induced PARP activation mediates recruitment of Drosophila Mi-2 to promote heat shock gene expression

31 March 2020

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Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose)

31 March 2020

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Structural basis of poly(ADP-ribose) recognition by the multizinc binding domain of checkpoint with forkhead-associated and RING Domains (CHFR)

31 March 2020

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The macro domain protein family: structure, functions, and their potential therapeutic implications

31 March 2020

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Splicing regulates NAD metabolite binding to histone macroH2A.

31 March 2020

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Orphan macrodomain protein (human C6orf130) is an O-acyl-ADP-ribose deacylase: solution structure and catalytic properties

31 March 2020

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Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases

31 March 2020

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DNA repair factor APLF is a histone chaperone

31 March 2020

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Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler

31 March 2020

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The emerging power of chemical genetics

31 March 2020

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Poly(ADP-Ribose) polymerase inhibition: "targeted" therapy for triple-negative breast cancer

31 March 2020

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Poly(ADP-ribose) polymerase inhibition in cancer therapy: are we close to maturity?

31 March 2020

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Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors

31 March 2020

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Poly(ADP-ribose) polymerase (PARP) inhibition counteracts multiple manifestations of kidney disease in long-term streptozotocin-diabetic rat model

31 March 2020

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Poly(ADP-ribosyl)ation in relation to cancer and autoimmune disease

31 March 2020

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Inhibition of poly(ADP-ribose) polymerase attenuates the severity of acute pancreatitis and associated lung injury.

31 March 2020

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

31 March 2020

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

31 March 2020

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Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

31 March 2020

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Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study

31 March 2020

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Iniparib plus chemotherapy in metastatic triple-negative breast cancer

31 March 2020

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PARP inhibitors stumble in breast cancer

31 March 2020

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Failure of iniparib to inhibit poly(ADP-Ribose) polymerase in vitro

31 March 2020

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Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor

31 March 2020

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Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

31 March 2020

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Structural basis of selective inhibition of human tankyrases

31 March 2020

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Poly(ADP-ribose) polymerase inhibitors

31 March 2020

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Purification and Properties of a Glycohydrolase from Calf Thymus Splitting Ribose-Ribose Linkages of Poly(Adenosine Diphosphate Ribose)

31 March 2020

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12 December 2020

ADP-ribosylhydrolase 3 (ARH3), not poly(ADP-ribose) glycohydrolase (PARG) isoforms, is responsible for degradation of mitochondrial matrix-associated poly(ADP-ribose).

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12 December 2020

Poly(ADP-ribose) polymerase is a catalytic dimer and the automodification reaction is intermolecular

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12 December 2020

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

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12 December 2020

Identifiers

DOI

10.1038/NRM3376

1 reference

PubMed ID

22713970

Dimensions Publication ID

27 August 2017

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1 reference

PubMed ID

22713970