Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity. (Q35749931)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22307631%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

title

Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity (English)

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22 January 2020

2

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22 January 2020

David P. Lane

8

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22 January 2020

Michael B Mann

5

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author name string

Amanda M Goh

1

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22 January 2020

Poh Cheang Chiam

3

1 reference

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22 January 2020

Ling Li

4

1 reference

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22 January 2020

Karen M Mann

6

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22 January 2020

Sergio Menendez

7

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22 January 2020

language of work or name

English

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publication date

17 January 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22307631%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

22 January 2020

published in

1 reference

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22 January 2020

volume

109

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22 January 2020

issue

5

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22 January 2020

page(s)

1685-1690

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describes a project that uses

22 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3277193/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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27 July 2018

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Targeted transgenesis at the HPRT locus: an efficient strategy to achieve tightly controlled in vivo conditional expression with the tet system

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A complex barcode underlies the heterogeneous response of p53 to stress

27 July 2018

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Acetylation is indispensable for p53 activation

27 July 2018

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Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

27 July 2018

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TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes

27 July 2018

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The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

27 July 2018

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Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation

27 July 2018

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Suppression of tumorigenesis by the p53 target PUMA

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

27 July 2018

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Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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p21 is a universal inhibitor of cyclin kinases

27 July 2018

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WAF1, a potential mediator of p53 tumor suppression

27 July 2018

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Expression of p53 during mouse embryogenesis

27 July 2018

1 reference

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Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

27 July 2018

1 reference

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MDM4 downregulates p53 transcriptional activity and response to stress during differentiation.

21 January 2018

1 reference

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Activation of the p53-dependent G1 checkpoint response in mouse embryo fibroblasts depends on the specific DNA damage inducer

21 January 2018

1 reference

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Tissue-specific p53 responses to ionizing radiation and their genetic modification: the key to tissue-specific tumour susceptibility?

21 January 2018

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Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA.

21 January 2018

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Comparative binding of p53 to its promoter and DNA recognition elements.

21 January 2018

1 reference

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p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1114173109

Modeling the therapeutic efficacy of p53 restoration in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1114173109

Restoration of p53 function leads to tumour regression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1114173109

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1114173109

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1114173109

Stage-specific sensitivity to p53 restoration during lung cancer progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1114173109

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

21 January 2018

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Cre-mediated chromosome loss in mice

21 January 2018

1 reference

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Bioluminescent molecular imaging of endogenous and exogenous p53-mediated transcription in vitro and in vivo using an HCT116 human colon carcinoma xenograft model

21 January 2018

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12 December 2020

Induction of endogenous beta-galactosidase by ionizing radiation complicates the analysis of p53-LacZ transgenic mice

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12 December 2020

p53 is preferentially recruited to the promoters of growth arrest genes p21 and GADD45 during replicative senescence of normal human fibroblasts

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12 December 2020

Real-time evaluation of p53 oscillatory behavior in vivo using bioluminescent imaging

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12 December 2020

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1114173109

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22307631%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22307631%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22307631%20AND%20SRC:MED&resulttype=core&format=json