New and emerging pharmacological targets for neuropathic pain (Q35759329)

10 August 2017

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title

New and emerging pharmacological targets for neuropathic pain (English)

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10 August 2017

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Donald C Manning

1

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10 August 2017

language of work or name

English

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publication date

1 June 2004

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Current Pain and Headache Reports

10 August 2017

published in

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10 August 2017

volume

8

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10 August 2017

issue

3

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10 August 2017

page(s)

192-198

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Beyond neurons: evidence that immune and glial cells contribute to pathological pain states

10 August 2017

cites work

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https://api.crossref.org/works/10.1007%2FS11916-004-0051-7

TNF-alpha expression in painful and nonpainful neuropathies.

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Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells

21 January 2018

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The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11916-004-0051-7

Lack of efficacy of riluzole in the treatment of peripheral neuropathic pain conditions

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Ubiquitin and the synapse.

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Neuronal plasticity: increasing the gain in pain

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12 December 2020

A role of the ubiquitin-proteasome system in neuropathic pain

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KCNQ/M currents in sensory neurons: significance for pain therapy.

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Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway

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12 December 2020

Control of synaptic strength by glial TNFalpha

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12 December 2020

Pro- and anti-inflammatory cytokine gene expression in rat sciatic nerve chronic constriction injury model of neuropathic pain

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12 December 2020

A role for c-Jun N-terminal kinase in the inhibition of long-term potentiation by interleukin-1beta and long-term depression in the rat dentate gyrus in vitro

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Ubiquitination precedes internalization and proteolytic cleavage of plasma membrane-bound glycine receptors

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12 December 2020

2000 Volvo Award winner in basic science studies: Exogenous tumor necrosis factor-alpha mimics nucleus pulposus-induced neuropathology. Molecular, histologic, and behavioral comparisons in rats

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Regulatory subunits of cAMP-dependent protein kinases are degraded after conjugation to ubiquitin: a molecular mechanism underlying long-term synaptic plasticity

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12 December 2020

The p38 signal transduction pathway: activation and function

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12 December 2020

ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases

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12 December 2020

Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome

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12 December 2020

Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury

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12 December 2020

Epineurial application of TNF elicits an acute mechanical hyperalgesia in the awake rat.

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12 December 2020

Tumour necrosis factor-alpha induces ectopic activity in nociceptive primary afferent fibres

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Drug discovery in the ubiquitin regulatory pathway

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Neuronal KCNQ potassium channels: physiology and role in disease.

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AP-1--glucocorticoid receptor crosstalk taken to a higher level

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Regulation of the cardiac voltage-gated Na+ channel (H1) by the ubiquitin-protein ligase Nedd4.

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Sprouting of peripherally regenerating primary sensory neurones in the adult central nervous system

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Phosphorylation of extracellular signal-regulated kinase in primary afferent neurons by noxious stimuli and its involvement in peripheral sensitization.

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Reorganization of central terminals of myelinated primary afferents in the rat dorsal horn following peripheral axotomy.

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SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

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Ubiquitin and AP180 regulate the abundance of GLR-1 glutamate receptors at postsynaptic elements in C. elegans

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Possible role of inflammatory mediators in tactile hypersensitivity in rat models of mononeuropathy

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Anti-inflammatory interleukin-10 therapy in CCI neuropathy decreases thermal hyperalgesia, macrophage recruitment, and endoneurial TNF-alpha expression.

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Inducible genetic suppression of neuronal excitability

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Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain

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Tumor necrosis factor enhances the capsaicin sensitivity of rat sensory neurons

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The Role of Cytokines in the Initiation and Maintenance of Chronic Pain

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Schwann cells produce tumor necrosis factor alpha: expression in injured and non-injured nerves

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Peripheral axotomy induces long-term c-Jun amino-terminal kinase-1 activation and activator protein-1 binding activity by c-Jun and junD in adult rat dorsal root ganglia In vivo.

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Nature of the retrograde signal from injured nerves that induces interleukin-6 mRNA in neurons

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The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic pain

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12 December 2020

Anterograde TNF alpha transport from rat dorsal root ganglion to spinal cord and injured sciatic nerve

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12 December 2020

MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo

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12 December 2020

Potassium channels: basic aspects, functional roles, and medical significance

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12 December 2020

Cytokines in sural nerve biopsies from inflammatory and non-inflammatory neuropathies

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12 December 2020

Altered expression and uptake activity of spinal glutamate transporters after nerve injury contribute to the pathogenesis of neuropathic pain in rats.

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12 December 2020

Selective interaction of JNK protein kinase isoforms with transcription factors

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12 December 2020

Distinct potassium channels on pain-sensing neurons

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12 December 2020

Chronic neuropathic pain is accompanied by global changes in gene expression and shares pathobiology with neurodegenerative diseases

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12 December 2020

Intramuscular injection of tumor necrosis factor-alpha induces muscle hyperalgesia in rats

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12 December 2020

The role of neuroinflammation and neuroimmune activation in persistent pain

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12 December 2020

A phase 2 study of bortezomib in relapsed, refractory myeloma

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12 December 2020

Cross-talk between glucocorticoid receptor and AP-1.

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12 December 2020

Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels

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12 December 2020

Tumor necrosis factor alpha inhibits glutamate uptake by primary human astrocytes. Implications for pathogenesis of HIV-1 dementia

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12 December 2020

Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons

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12 December 2020

Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain.

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12 December 2020

AMPA receptor trafficking: a road map for synaptic plasticity

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12 December 2020

Extracellular-signal-regulated kinase signalling in neurons

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12 December 2020

Spinal nerve ligation induces transient upregulation of tumor necrosis factor receptors 1 and 2 in injured and adjacent uninjured dorsal root ganglia in the rat.

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12 December 2020

Dynamic balance of metabotropic inputs causes dorsal horn neurons to switch functional states

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12 December 2020

Tumor necrosis factor-alpha monoclonal antibody, infliximab, used to manage severe sciatica.

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12 December 2020

Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system

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12 December 2020

Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain.

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12 December 2020

Reduction of potassium currents and phosphatidylinositol 3-kinase-dependent AKT phosphorylation by tumor necrosis factor-(alpha) rescues axotomized retinal ganglion cells from retrograde cell death in vivo.

1 reference

12 December 2020

10.1007/S11916-004-0051-7

Identifiers

DOI

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10 August 2017

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