Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways (Q35763674)

10 August 2017

title

Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways (English)

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10 August 2017

7

Lewis E Kay

1 reference

10 August 2017

Guillaume Bouvignies

5

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author name string

Ashok Sekhar

1

1 reference

10 August 2017

Jessica A O Rumfeldt

2

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10 August 2017

Helen R Broom

3

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10 August 2017

Colleen M Doyle

4

1 reference

10 August 2017

Elizabeth M Meiering

6

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10 August 2017

language of work or name

English

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publication date

23 June 2015

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10 August 2017

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10 August 2017

volume

4

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10 August 2017

page(s)

e07296

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Triple resonance-based ¹³C(α) and ¹³C(β) CEST experiments for studies of ms timescale dynamics in proteins

10 August 2017

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2 October 2017

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Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis.

2 October 2017

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Molecular dynamics using atomic-resolution structure reveal structural fluctuations that may lead to polymerization of human Cu Zn superoxide dismutase

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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12 July 2018

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12 July 2018

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Many roads lead to Rome? Multiple modes of Cu,Zn superoxide dismutase destabilization, misfolding and aggregation in amyotrophic lateral sclerosis

12 July 2018

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25 September 2018

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25 September 2018

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Calorimetric analysis of thermodynamic stability and aggregation for apo and holo amyotrophic lateral sclerosis-associated Gly-93 mutants of superoxide dismutase

25 September 2018

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Fully metallated S134N Cu,Zn-superoxide dismutase displays abnormal mobility and intermolecular contacts in solution

25 September 2018

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Amyotrophic lateral sclerosis mutations have the greatest destabilizing effect on the apo- and reduced form of SOD1, leading to unfolding and oxidative aggregation.

25 September 2018

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25 September 2018

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Effects of Diffusion on Free Precession in Nuclear Magnetic Resonance Experiments

25 September 2018

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Tetramer Dissociation and Monomer Partial Unfolding Precedes Protofibril Formation in Amyloidogenic Transthyretin Variants

21 January 2018

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Local cooperativity in the unfolding of an amyloidogenic variant of human lysozyme

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Production and Incorporation of15N,13C,2H (1H-δ1 Methyl) Isoleucine into Proteins for Multidimensional NMR Studies

21 January 2018

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Sequence and structural determinants of Cu, Zn superoxide dismutase aggregation

21 January 2018

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Fractional 13C enrichment of isolated carbons using [1-13C]- or [2-13C]-glucose facilitates the accurate measurement of dynamics at backbone Cα and side-chain methyl positions in proteins

21 January 2018

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Heteronuclear multidimensional NMR experiments for the structure determination of proteins in solution employing pulsed field gradients

21 January 2018

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Sporadic amyotrophic lateral sclerosis with dementia and Cu/Zn superoxide dismutase-positive Lewy body-like inclusions

21 January 2018

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12 December 2020

13C NMR chemical shifts can predict disulfide bond formation

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12 December 2020

Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite

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12 December 2020

Composition of soluble misfolded superoxide dismutase-1 in murine models of amyotrophic lateral sclerosis

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12 December 2020

A single-quantum methyl 13C-relaxation dispersion experiment with improved sensitivity

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12 December 2020

The unusually stable quaternary structure of human Cu,Zn-superoxide dismutase 1 is controlled by both metal occupancy and disulfide status

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12 December 2020

The folding pathway of an FF domain: characterization of an on-pathway intermediate state under folding conditions by (15)N, (13)C(alpha) and (13)C-methyl relaxation dispersion and (1)H/(2)H-exchange NMR spectroscopy

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12 December 2020

Equilibrium thermodynamic analysis of amyotrophic lateral sclerosis-associated mutant apo Cu,Zn superoxide dismutases

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12 December 2020

Amide proton temperature coefficients as hydrogen bond indicators in proteins

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An NMR experiment for the accurate measurement of heteronuclear spin-lock relaxation rates

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12 December 2020

Identifiers

DOI

10.7554/ELIFE.07296

1 reference

10 August 2017

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10 August 2017

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