MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition. (Q35781547)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25803170%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

title

MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition (English)

1 reference

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3 March 2020

1

1 reference

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3 March 2020

Rachael O'Connor

5

1 reference

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3 March 2020

Aimee M Crago

11

1 reference

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3 March 2020

Andrew Koff

12

1 reference

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3 March 2020

author name string

David D Liu

2

1 reference

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3 March 2020

Mark A Dickson

3

1 reference

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3 March 2020

Mary E Klein

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25803170%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Fatima O Wilder

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25803170%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Nicholas D Socci

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25803170%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

William D Tap

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25803170%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Gary K Schwartz

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25803170%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Samuel Singer

10

1 reference

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3 March 2020

language of work or name

English

0 references

publication date

1 April 2015

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3 March 2020

1 reference

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3 March 2020

volume

6

1 reference

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3 March 2020

issue

10

1 reference

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3 March 2020

page(s)

8226-8243

1 reference

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Geroconversion: irreversible step to cellular senescence

3 March 2020

cites work

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CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer

12 July 2018

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CDK 4/6 inhibitors sensitize PIK3CA mutant breast cancer to PI3K inhibitors

12 July 2018

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Chromatin remodeling: from transcription to cancer

12 July 2018

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The emergence of targeted drugs in breast cancer to prevent resistance to endocrine treatment and chemotherapy

12 July 2018

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12 July 2018

S6K in geroconversion

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Anti-c-Met antibodies recognising a temperature sensitive epitope, inhibit cell growth

12 July 2018

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Probing the depths of cellular senescence

12 July 2018

1 reference

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Phase II trial of the CDK4 inhibitor PD0332991 in patients with advanced CDK4-amplified well-differentiated or dedifferentiated liposarcoma.

12 July 2018

1 reference

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Inhibition of TWIST1 leads to activation of oncogene-induced senescence in oncogene-driven non-small cell lung cancer.

12 July 2018

1 reference

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Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy

12 July 2018

1 reference

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ATRX: the case of a peculiar chromatin remodeler

12 July 2018

1 reference

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DNA damage checkpoints in stem cells, ageing and cancer.

12 July 2018

1 reference

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Regulation of transcription and chromatin structure by pRB: here, there and everywhere

12 July 2018

1 reference

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Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway

12 July 2018

1 reference

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The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence

12 July 2018

1 reference

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Cellular senescence as a possible mechanism for halting progression of keloid lesions.

12 July 2018

1 reference

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E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

The role of CUGBP1 in age-dependent changes of liver functions

12 July 2018

1 reference

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ATRX-mediated chromatin association of histone variant macroH2A1 regulates α-globin expression

12 July 2018

1 reference

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Translation-dependent mechanisms lead to PML upregulation and mediate oncogenic K-RAS-induced cellular senescence

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy

12 July 2018

1 reference

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A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Cellular senescence and tumor suppressor gene p16

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

p53 and p16(INK4A) independent induction of senescence by chromatin-dependent alteration of S-phase progression

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Cyclin D1 and cdk4 mediate development of neurologically destructive oligodendroglioma

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Altered telomeres in tumors with ATRX and DAXX mutations

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Phase I study of PD 0332991, a cyclin-dependent kinase inhibitor, administered in 3-week cycles (Schedule 2/1).

12 July 2018

1 reference

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Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a).

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Cellular senescence: putting the paradoxes in perspective

12 July 2018

1 reference

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The essence of senescence

12 July 2018

1 reference

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The BioGRID Interaction Database: 2011 update

12 July 2018

1 reference

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Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

HdmX overexpression inhibits oncogene induced cellular senescence

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Distinct factors control histone variant H3.3 localization at specific genomic regions

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Oncogene-induced cellular senescence

12 July 2018

1 reference

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Senescence-messaging secretome: SMS-ing cellular stress

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

STRING 8--a global view on proteins and their functional interactions in 630 organisms

12 July 2018

1 reference

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Functional copy-number alterations in cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Many roads lead to oncogene-induced senescence

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Cellular senescence: when bad things happen to good cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Ubiquitination and degradation of the anti-apoptotic protein ARC by MDM2.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Requirement for CDK4 kinase function in breast cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

A dynamic role of HAUSP in the p53-Mdm2 pathway

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

The MDM2-p53 interaction.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

The role of PML in tumor suppression

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Telomerase activity and telomere length in pediatric patients with malignancies undergoing chemotherapy.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

The biology of replicative senescence

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Blockbuster dreams for Pfizer's CDK inhibitor.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Quantitative assessment of markers for cell senescence.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Gene expression profiling of liposarcoma identifies distinct biological types/subtypes and potential therapeutic targets in well-differentiated and dedifferentiated liposarcoma.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

The p53--Mdm2--HAUSP complex is involved in p53 stabilization by HAUSP.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

ROS as a tumour suppressor?

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

The power and the promise of oncogene-induced senescence markers.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480747

Telomere Maintenance Mechanisms in Liposarcomas: Association with Histologic Subtypes and Disease Progression

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25803170

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.3364

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25803170%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25803170%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

PubMed publication ID

25803170

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25803170%20AND%20SRC:MED&resulttype=core&format=json