DNA damage checkpoints in stem cells, ageing and cancer. (Q38036830)

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11 February 2020

title

DNA damage checkpoints in stem cells, ageing and cancer (English)

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11 February 2020

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11 February 2020

author name string

Tobias Sperka

series ordinal

1

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11 February 2020

Jianwei Wang

series ordinal

2

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11 February 2020

language of work or name

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1 September 2012

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11 February 2020

number of pages

12

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Nature Reviews Molecular Cell Biology

inferred from page(s)

published in

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11 February 2020

volume

13

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11 February 2020

issue

9

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11 February 2020

page(s)

579-590

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https://scigraph.springernature.com/pub.10.1038/nrm3420

11 February 2020

exact match

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cites work

The common biology of cancer and ageing

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Stem cells, ageing and the quest for immortality.

31 March 2020

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Bmi1 is expressed in vivo in intestinal stem cells

31 March 2020

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An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration

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A role for adult TLX-positive neural stem cells in learning and behaviour

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Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age.

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Cell intrinsic alterations underlie hematopoietic stem cell aging.

31 March 2020

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Age-associated characteristics of murine hematopoietic stem cells

31 March 2020

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The aging of hematopoietic stem cells

31 March 2020

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A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells

31 March 2020

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Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

31 March 2020

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Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1.

31 March 2020

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Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment.

31 March 2020

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Immunoaging induced by hematopoietic stem cell aging.

31 March 2020

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Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells

31 March 2020

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Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment

31 March 2020

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Telomere dysfunctional environment induces loss of quiescence and inherent impairments of hematopoietic stem cell function

31 March 2020

1 reference

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

31 March 2020

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A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage

31 March 2020

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A population of myogenic stem cells that survives skeletal muscle aging.

31 March 2020

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Aging of hematopoietic stem cells: Intrinsic changes or micro-environmental effects?

31 March 2020

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DNA damage response in adult stem cells: pathways and consequences

31 March 2020

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DNA-damage response in tissue-specific and cancer stem cells

31 March 2020

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Response of normal stem cells to ionizing radiation: a balance between homeostasis and genomic stability

31 March 2020

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Essential role of mouse telomerase in highly proliferative organs

31 March 2020

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Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

31 March 2020

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Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1-/- mice

31 March 2020

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Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss

31 March 2020

1 reference

DNA repair is limiting for haematopoietic stem cells during ageing

31 March 2020

1 reference

Repopulating defect of mismatch repair–deficient hematopoietic stem cells

31 March 2020

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Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis

31 March 2020

1 reference

Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death

31 March 2020

1 reference

E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints

31 March 2020

1 reference

Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair

31 March 2020

1 reference

Extension of life-span by introduction of telomerase into normal human cells

31 March 2020

1 reference

A DNA damage checkpoint response in telomere-initiated senescence

31 March 2020

1 reference

DNA damage foci at dysfunctional telomeres

31 March 2020

1 reference

Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts

31 March 2020

1 reference

The two-stage mechanism controlling cellular senescence and immortalization

31 March 2020

1 reference

The DNA-damage response in human biology and disease

31 March 2020

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A role for both RB and p53 in the regulation of human cellular senescence

31 March 2020

1 reference

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

31 March 2020

1 reference

Cellular senescence in aging primates.

31 March 2020

1 reference

Ink4a/Arf expression is a biomarker of aging

31 March 2020

1 reference

Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging

31 March 2020

1 reference

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

31 March 2020

1 reference

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

31 March 2020

1 reference

Thymocyte apoptosis induced by p53-dependent and independent pathways.

31 March 2020

1 reference

The role of apoptosis in the normal aging brain, skeletal muscle, and heart

31 March 2020

1 reference

Clearance of apoptotic cells: implications in health and disease

31 March 2020

1 reference

A central role for ceramide in the age-related acceleration of apoptosis in the female germline

31 March 2020

1 reference

Absence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female mice

31 March 2020

1 reference

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

31 March 2020

1 reference

Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction.

31 March 2020

1 reference

p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice

31 March 2020

1 reference

Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation

31 March 2020

1 reference

A model of the control of cellular regeneration in the intestinal crypt after perturbation based solely on local stem cell regulation

31 March 2020

1 reference

Distinct regulatory mechanisms and functions for p53-activated and p53-repressed DNA damage response genes in embryonic stem cells

31 March 2020

1 reference

Batf coordinates multiple aspects of B and T cell function required for normal antibody responses

31 March 2020

1 reference

Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice

31 March 2020

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Enrichment of hematopoietic stem cells with SLAM and LSK markers for the detection of hematopoietic stem cell function in normal and Trp53 null mice

31 March 2020

1 reference

p53-mediated hematopoietic stem and progenitor cell competition.

31 March 2020

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Disruption of Trp53 in livers of mice induces formation of carcinomas with bilineal differentiation.

31 March 2020

1 reference

p53 suppresses the self-renewal of adult neural stem cells.

31 March 2020

1 reference

p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal

31 March 2020

1 reference

p53: guardian of reprogramming

31 March 2020

1 reference

The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells.

31 March 2020

1 reference

A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal.

31 March 2020

1 reference

p53 regulates hematopoietic stem cell quiescence.

31 March 2020

1 reference

The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging

31 March 2020

1 reference

Lifespan extension by preserving proliferative homeostasis in Drosophila

31 March 2020

1 reference

Hematopoietic stem cell quiescence maintained by p21cip1/waf1

31 March 2020

1 reference

p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity

31 March 2020

1 reference

A Limited role for p21Cip1/Waf1 in maintaining normal hematopoietic stem cell functioning.

31 March 2020

1 reference

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

31 March 2020

1 reference

ATR: an essential regulator of genome integrity

31 March 2020

1 reference

Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation

31 March 2020

1 reference

The ATM-BID pathway regulates quiescence and survival of haematopoietic stem cells

31 March 2020

1 reference

p16INK4a induces an age-dependent decline in islet regenerative potential

31 March 2020

1 reference

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

31 March 2020

1 reference

Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging

31 March 2020

1 reference

Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

31 March 2020

1 reference

Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression

31 March 2020

1 reference

Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations

31 March 2020

1 reference

Hematopoietic stem cell ageing is uncoupled from p16 INK4A-mediated senescence.

31 March 2020

1 reference

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

31 March 2020

1 reference

A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress

31 March 2020

1 reference

The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis.

31 March 2020

1 reference

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

31 March 2020

1 reference

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

31 March 2020

1 reference

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

31 March 2020

1 reference

Influence of ATM function on telomere metabolism

31 March 2020

1 reference

ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling

31 March 2020

1 reference

Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice

31 March 2020

1 reference

Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility

31 March 2020

1 reference

EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutants

31 March 2020

1 reference

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

31 March 2020

1 reference

Ionizing radiation-induced expression of INK4a/ARF in murine bone marrow-derived stromal cell populations interferes with bone marrow homeostasis.

31 March 2020

1 reference

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

31 March 2020

1 reference

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

31 March 2020

1 reference

PLEIOTROPY, NATURAL SELECTION, AND THE EVOLUTION OF SENESCENCE

31 March 2020

1 reference

On the programmed/non-programmed nature of ageing within the life history

31 March 2020

1 reference

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

31 March 2020

1 reference

Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation

31 March 2020

1 reference

Deficient mismatch repair improves organismal fitness and survival of mice with dysfunctional telomeres

31 March 2020

1 reference

The price of tumour suppression?

31 March 2020

1 reference

p53 mutant mice that display early ageing-associated phenotypes

31 March 2020

1 reference

"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

31 March 2020

1 reference

Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging.

31 March 2020

1 reference

Tumor suppression and normal aging in mice with constitutively high p53 activity

31 March 2020

1 reference

Delayed ageing through damage protection by the Arf/p53 pathway

31 March 2020

1 reference

Telomerase reverse transcriptase delays aging in cancer-resistant mice

31 March 2020

1 reference

Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation

31 March 2020

1 reference

Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death.

31 March 2020

1 reference

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

31 March 2020

1 reference

Irradiation selects for p53-deficient hematopoietic progenitors.

31 March 2020

1 reference

Aging and genome maintenance: lessons from the mouse?

31 March 2020

1 reference

DNA repair, genome stability, and aging

31 March 2020

1 reference

Telomere shortening and ageing.

31 March 2020

1 reference

Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis

31 March 2020

1 reference

Chromosomal instability in ulcerative colitis is related to telomere shortening

31 March 2020

1 reference

DNA Damage, Aging, and Cancer

31 March 2020

1 reference

Telomere length in early life predicts lifespan.

31 March 2020

1 reference

Telomere shortening and survival in free-living corvids.

31 March 2020

1 reference

Association between telomere length in blood and mortality in people aged 60 years or older

31 March 2020

1 reference

Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease

31 March 2020

1 reference

Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer disease.

31 March 2020

1 reference

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

31 March 2020

1 reference

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence.

31 March 2020

1 reference

Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication

31 March 2020

1 reference

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.

31 March 2020

1 reference

Aging is associated with increased clonogenic potential in rat liver in vivo.

31 March 2020

1 reference

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

31 March 2020

1 reference

A growth-constrained environment drives tumor progression invivo

31 March 2020

1 reference

Impaired DNA replication within progenitor cell pools promotes leukemogenesis.

31 March 2020

1 reference

Relative fitness of hematopoietic progenitors influences leukemia progression.

31 March 2020

1 reference

The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

31 March 2020

1 reference

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.

31 March 2020

1 reference

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

31 March 2020

1 reference

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.

31 March 2020

1 reference

CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis

31 March 2020

1 reference

Telomeres: protecting chromosomes against genome instability

31 March 2020

1 reference

12 December 2020

Telomere shortening associated with disease evolution patterns in myelodysplastic syndromes

1 reference

12 December 2020

Puma is required for p53-induced depletion of adult stem cells

1 reference

12 December 2020

Increased p53 activity does not accelerate telomere-driven ageing

1 reference

12 December 2020

Reproductive aging in the Brown Norway rat is characterized by accelerated germ cell apoptosis and is not altered by luteinizing hormone replacement

1 reference

12 December 2020

Modification of irradiation injury in mice and guinea pigs by bone marrow injections

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRM3420

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22914294%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

11 February 2020

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