The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes (Q35811523)

10 August 2017

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes (English)

1 reference

10 August 2017

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1 reference

4

Gerald I Shulman

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10 August 2017

3

Kitt F Petersen

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10 August 2017

2

Varman T Samuel

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10 August 2017

1

Rachel J Perry

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PMCID

4489847

10 August 2017

language of work or name

English

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publication date

1 June 2014

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10 August 2017

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10 August 2017

510

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10 August 2017

84-91

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10 August 2017

7503

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https://scigraph.springernature.com/pub.10.1038/nature13478

10 August 2017

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Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice

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Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance

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CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance

27 July 2018

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Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats

27 July 2018

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AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues

27 July 2018

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Dissociating fatty liver and diabetes

27 July 2018

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Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism.

27 July 2018

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Skeletal muscle insulin resistance promotes increased hepatic de novo lipogenesis, hyperlipidemia, and hepatic steatosis in the elderly

27 July 2018

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Endoplasmic reticulum stress is involved in hepatic SREBP-1c activation and lipid accumulation in fructose-fed mice

27 July 2018

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Allosteric regulation of the biotin-dependent enzyme pyruvate carboxylase by acetyl-CoA.

27 July 2018

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Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

27 July 2018

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Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase

27 July 2018

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The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance

27 July 2018

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Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes

27 July 2018

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The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans

27 July 2018

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Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver

27 July 2018

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Mechanisms for insulin resistance: common threads and missing links

27 July 2018

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Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones.

27 July 2018

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Localisation and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans.

27 July 2018

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Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease

27 July 2018

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Thyroid hormone receptor-α gene knockout mice are protected from diet-induced hepatic insulin resistance

27 July 2018

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Regulation of the structure and activity of pyruvate carboxylase by acetyl CoA

27 July 2018

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Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

27 July 2018

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Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals

27 July 2018

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Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice

27 July 2018

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Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance

27 July 2018

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Phosphatidylcholine protects against steatosis in mice but not non-alcoholic steatohepatitis

27 July 2018

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Human fatty liver disease: old questions and new insights

27 July 2018

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Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2

27 July 2018

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Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits

27 July 2018

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Perilipin deficiency and autosomal dominant partial lipodystrophy

27 July 2018

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Dissociation between APOC3 variants, hepatic triglyceride content and insulin resistance

27 July 2018

1 reference

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Liver ATP synthesis is lower and relates to insulin sensitivity in patients with type 2 diabetes.

27 July 2018

1 reference

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A promoter polymorphism in the liver-specific fatty acid transport protein 5 is associated with features of the metabolic syndrome and steatosis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Insulin signaling meets mitochondria in metabolism

27 July 2018

1 reference

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Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity

27 July 2018

1 reference

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Involvement of microsomal triglyceride transfer protein in nonalcoholic steatohepatitis in novel spontaneous mouse model

27 July 2018

1 reference

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Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease

27 July 2018

1 reference

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Nonobese population in a developing country has a high prevalence of nonalcoholic fatty liver and significant liver disease

27 July 2018

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Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications

27 July 2018

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Lipid oversupply, selective insulin resistance, and lipotoxicity: molecular mechanisms

27 July 2018

1 reference

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Relationship between body fat mass and free fatty acid kinetics in men and women.

27 July 2018

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The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance.

27 July 2018

1 reference

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AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency

27 July 2018

1 reference

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The phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2.

27 July 2018

1 reference

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The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans

27 July 2018

1 reference

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Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia

27 July 2018

1 reference

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Loss of resistin ameliorates hyperlipidemia and hepatic steatosis in leptin-deficient mice

27 July 2018

1 reference

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Selective versus total insulin resistance: a pathogenic paradox

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome

27 July 2018

1 reference

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Weight regain in U.S. adults who experienced substantial weight loss, 1999-2002.

27 July 2018

1 reference

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Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance

27 July 2018

1 reference

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Spectrum of liver disease in type 2 diabetes and management of patients with diabetes and liver disease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men.

27 July 2018

1 reference

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A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice

27 July 2018

1 reference

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Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Design and validation of a histological scoring system for nonalcoholic fatty liver disease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

The "obese insulin-sensitive" adolescent: importance of adiponectin and lipid partitioning

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Mechanism of free fatty acid-induced insulin resistance in humans

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Liver pathology in morbidly obese patients with and without diabetes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Fructose-2,6-Bisphosphate in Control of Hepatic Gluconeogenesis: From Metabolites to Molecular Genetics

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Cholesterol-induced hepatic inflammation does not contribute to the development of insulin resistance in male LDL receptor knockout mice.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Dissociation of hepatic insulin resistance from susceptibility of nonalcoholic fatty liver disease induced by a high-fat and high-carbohydrate diet in mice.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Impaired amino acid metabolism contributes to fasting-induced hypoglycemia in fatty acid oxidation defects.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese population.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Opuntia ficus indica (nopal) attenuates hepatic steatosis and oxidative stress in obese Zucker (fa/fa) rats.

24 September 2018

1 reference

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Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States.

24 September 2018

1 reference

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Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Abnormal hepatic energy homeostasis in type 2 diabetes

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Increased expression and activity of hepatic lipase in the liver of morbidly obese adult patients in relation to lipid content.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Prevalence of and risk factors for fatty liver in a general population of Shanghai, China

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Effect of leptin replacement on intrahepatic and intramyocellular lipid content in patients with generalized lipodystrophy

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Cellular mechanisms of insulin resistance

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Triglyceride-induced diabetes associated with familial lipoprotein lipase deficiency.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the Liver

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals

22 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4489847

The prevalence of weight loss maintenance among American adults

6 December 2018

1 reference

12 December 2020

Mechanism of insulin resistance in A-ZIP/F-1 fatless mice

1 reference

12 December 2020

Hepatocyte-specific Ptpn6 deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: potential role of PPARγ

1 reference

12 December 2020

Non-alcoholic fatty liver disease as an independent manifestation of the metabolic syndrome: Results of a US national survey in three ethnic groups

1 reference

12 December 2020

Effects of free fatty acids on the metabolic response to oral fructose in lean healthy humans

1 reference

12 December 2020

Energy expenditure and adaptive responses to an acute hypercaloric fat load in humans with lipodystrophy

1 reference

12 December 2020

How common is non-alcoholic fatty liver disease in the Asia-Pacific region and are there local differences?

1 reference

12 December 2020

A position statement on NAFLD/NASH based on the EASL 2009 special conference

1 reference

12 December 2020

Visceral obesity modulates the impact of apolipoprotein C3 gene variants on liver fat content

1 reference

12 December 2020

Identifiers

DOI

10.1038/NATURE13478

1 reference

10 August 2017

1 reference

10 August 2017

1 reference

PMCID

4489847