The structure and function of insulin: decoding the TR transition (Q35814655)

10 August 2017

The structure and function of insulin: decoding the TR transition (English)

1 reference

10 August 2017

Michael A Weiss

1

1 reference

10 August 2017

1 January 2009

1 reference

10 August 2017

Vitamins and Hormones

1 reference

10 August 2017

80

1 reference

10 August 2017

33-49

1 reference

The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition

10 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Structural insights into ligand-induced activation of the insulin receptor.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Proinsulin maturation, misfolding, and proteotoxicity

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Insulin gene mutations as a cause of permanent neonatal diabetes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Structure of the insulin receptor ectodomain reveals a folded-over conformation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

A conserved histidine in insulin is required for the foldability of human proinsulin: structure and function of an ALAB5 analog

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Chiral mutagenesis of insulin. Foldability and function are inversely regulated by a stereospecific switch in the B chain

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

The binding of thioflavin-T to amyloid fibrils: localisation and implications

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Endoplasmic reticulum stress and diabetes mellitus.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Mechanism of insulin chain combination. Asymmetric roles of A-chain alpha-helices in disulfide pairing

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Chiral mutagenesis of insulin's hidden receptor-binding surface: structure of an allo-isoleucine(A2) analogue

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

A cavity-forming mutation in insulin induces segmental unfolding of a surrounding α-helix

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Solution structure of an engineered insulin monomer at neutral pH

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Role of C-terminal B-chain residues in insulin assembly: the structure of hexameric LysB28ProB29-human insulin

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Structural stability in the 4-zinc human insulin hexamer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Hormone families: pancreatic hormones and homologous growth factors

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Atomic Positions in Rhombohedral 2-Zinc Insulin Crystals

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

The structure of 2Zn pig insulin crystals at 1.5 A resolution

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Spectroscopic signatures of the T to R conformational transition in the insulin hexamer.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Role of the phenylalanine B24 side chain in directing insulin interaction with its receptor. Importance of main chain conformation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Importance of the character and configuration of residues B24, B25, and B26 in insulin-receptor interactions

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Receptor binding redefined by a structural switch in a mutant human insulin

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Insulin hexamers: new conformations and applications

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

X-ray analysis of the single chain B29-A1 peptide-linked insulin molecule. A completely inactive analogue.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Structure of insulin in 4-zinc insulin

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Rhombohedral insulin crystal transformation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Receptor-binding region of insulin

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Heterozygous missense mutations in the insulin gene are linked to permanent diabetes appearing in the neonatal period or in early infancy: a report from the French ND (Neonatal Diabetes) Study Group

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Mutational analysis of the absolutely conserved B8Gly: consequence on foldability and activity of insulin

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Three mutant insulins in man

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297421

Structure of Rhombohedral 2 Zinc Insulin Crystals

24 September 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900602-X

7 January 2021

Monomeric insulins obtained by protein engineering and their medical implications

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900602-X

7 January 2021

Transmission of conformational change in insulin

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900602-X

7 January 2021

Phenol stabilizes more helix in a new symmetrical zinc insulin hexamer

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900602-X

7 January 2021

Steric requirements at position B12 for high biological activity in insulin

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900602-X

7 January 2021

Toward the active conformation of insulin: stereospecific modulation of a structural switch in the B chain

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900602-X

7 January 2021

Hierarchical protein folding: asymmetric unfolding of an insulin analogue lacking the A7-B7 interchain disulfide bridge

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900602-X

7 January 2021

Native and non-native structure in a protein-folding intermediate: spectroscopic studies of partially reduced IGF-I and an engineered alanine model

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900602-X

7 January 2021

Critical role of the A2 amino acid residue in the biological activity of insulin: [2-glycine-A]- and [2-alanine-A]insulins

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900602-X

7 January 2021

A proposed interaction model of the insulin molecule with its receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900602-X

7 January 2021

Importance of aliphatic side-chain structure at positions 2 and 3 of the insulin A chain in insulin-receptor interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900602-X

7 January 2021

Mutational analysis of invariant valine B12 in insulin: implications for receptor binding

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900602-X

7 January 2021

Cobalt probing of structural alternatives for insulin in solution

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900602-X

7 January 2021

Hierarchical protein "un-design": insulin's intrachain disulfide bridge tethers a recognition alpha-helix

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900602-X

7 January 2021

Heteronuclear 2D NMR studies of an engineered insulin monomer: assignment and characterization of the receptor-binding surface by selective 2H and 13C labeling with application to protein design

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900602-X

7 January 2021

I222 crystal form of despentapeptide (B26-B30) insulin provides new insights into the properties of monomeric insulin

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900602-X

7 January 2021

Role of the phenylalanine B25 side chain in directing insulin interaction with its receptor. Steric and conformational effects

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19251033

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/S0083-6729(08)00602-X

1 reference

10 August 2017

1 reference

PMC publication ID

3297421

10 August 2017

PubMed publication ID

19251033

1 reference

PMC publication ID

3297421