A conserved histidine in insulin is required for the foldability of human proinsulin: structure and function of an ALAB5 analog (Q40275159)

19 September 2017

A conserved histidine in insulin is required for the foldability of human proinsulin: structure and function of an ALAB5 analog (English)

1 reference

19 September 2017

Qing-Xin Hua

1

1 reference

19 September 2017

Ming Liu

2

1 reference

19 September 2017

Shi-Quan Hu

3

1 reference

19 September 2017

Wenhua Jia

4

1 reference

19 September 2017

Peter Arvan

5

1 reference

19 September 2017

Michael A Weiss

6

1 reference

19 September 2017

language of work or name

English

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publication date

25 May 2006

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Journal of Biological Chemistry

19 September 2017

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19 September 2017

281

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19 September 2017

34

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19 September 2017

24889-24899

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The proprotein convertases

19 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Submillisecond folding of monomeric lambda repressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

A divergent INS protein in Caenorhabditis elegans structurally resembles human insulin and activates the human insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

A peptide model of insulin folding intermediate with one disulfide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Receptor-binding region of insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Structural biology of insulin and IGF1 receptors: implications for drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Chiral mutagenesis of insulin's hidden receptor-binding surface: structure of an allo-isoleucine(A2) analogue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Protein structure and the spandrels of San Marco: insulin's receptor-binding surface is buttressed by an invariant leucine essential for its stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Mechanism of insulin chain combination. Asymmetric roles of A-chain alpha-helices in disulfide pairing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Atomic Positions in Rhombohedral 2-Zinc Insulin Crystals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

A superactive insulin: [B10-aspartic acid]insulin(human).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Activities of monomeric insulin analogs at position A8 are uncorrelated with their thermodynamic stabilities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Role of the connecting peptide in insulin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Receptor binding redefined by a structural switch in a mutant human insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Solution structure of an engineered insulin monomer at neutral pH

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Mutations at the dimer, hexamer, and receptor-binding surfaces of insulin independently affect insulin-insulin and insulin-receptor interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Chiral mutagenesis of insulin. Foldability and function are inversely regulated by a stereospecific switch in the B chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Behavior in the eukaryotic secretory pathway of insulin-containing fusion proteins and single-chain insulins bearing various B-chain mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

There's a right way and a wrong way: in vivo and in vitro folding, misfolding and subunit assembly of the P22 tailspike

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

A self-consistent method for the analysis of protein secondary structure from circular dichroism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Application of circular dichroism to study RNA folding transitions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Mutational analysis of the absolutely conserved B8Gly: consequence on foldability and activity of insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Insulin synthesis by recombination of A and B chains: a highly efficient method

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

The insulin A and B chains contain structural information for the formation of the native molecule. Studies with protein disulphide-isomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Putative disulfide-forming pathway of porcine insulin precursor during its refolding in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Oxidative refolding of insulin-like growth factor 1 yields two products of similar thermodynamic stability: a bifurcating protein-folding pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Structure of insulin in 4-zinc insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Crystal structure of human insulin-like growth factor-1: detergent binding inhibits binding protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Structural origins of the functional divergence of human insulin-like growth factor-I and insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Coypu insulin. Primary structure, conformation and biological properties of a hystricomorph rodent insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Amino acid sequence from degu islet amyloid-derived insulin shows unique sequence characteristics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Cloning of complementary DNAs encoding islet amyloid polypeptide, insulin, and glucagon precursors from a New World rodent, the degu, Octodon degus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Crystal Structure ofallo-IleA2-Insulin, an Inactive Chiral Analogue: Implications for the Mechanism of Receptor Binding,

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin Wakayama.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Monomeric insulins obtained by protein engineering and their medical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

Phenol stabilizes more helix in a new symmetrical zinc insulin hexamer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602617200

21 January 2018

Identifiers

DOI

10.1074/JBC.M602617200

1 reference

19 September 2017

1 reference